Results 131 to 140 of about 1,534,638 (251)

Adenosine—A Regulator of Human Testicular Peritubular Cells

Andrology, EarlyView.
ABSTRACT Background Extracellular purines, in particular ATP and adenosine, are regulators of physiological and pathophysiological processes throughout the human body. Roles in the human testis are emerging and include actions on peritubular cells, which form the wall of seminiferous tubules.
Lina Scholz, Annika Liebich, Youli Stepanov, Jan B. Stöckl, Mirko Peitzsch, Michaela Schneider, Julia Schneider, Nicole Kreitmair, Matthias Trottmann, Frank‐Michael Köhn, Jovica Ninkovic, Thomas Fröhlich, Artur Mayerhofer   +12 more
wiley   +1 more source

The discovery and development of ensifentrine: A novel inhaled dual PDE3/4 inhibitor having ‘bifunctional’ bronchodilator and anti‐inflammatory activity

British Journal of Pharmacology, EarlyView.
Abstract Ensifentrine (formerly called RPL 554) is a novel, first in class, inhaled bifunctional dual PDE3/4 inhibitor for the treatment of chronic respiratory diseases. Ensifentrine exhibits both bronchodilation via PDE3 inhibition and anti‐inflammatory activity via PDE4 inhibition.
Clive Page
wiley   +1 more source

Inhibition of the MER tyrosine kinase ameliorates pulmonary fibrosis by suppressing macrophage M2 polarisation and osteopontin signalling

British Journal of Pharmacology, EarlyView.
Background and Purpose The MER proto‐oncogene tyrosine kinase (MERTK) has been implicated in the pathogenesis of pulmonary fibrosis (PF), and MERTK inhibition has been shown to ameliorate PF. However, the mechanisms remain unclear. Here, we have investigated how MERTK inhibition attenuates bleomycin (BLM)‐induced PF in mice and to elucidate the ...
Juan Li, Xiangsheng Yang, Xiao Xiao Tang
wiley   +1 more source

Effect of Acupuncture Intervention on Airway Remodeling and Transforming Growth Factor-β_1 Expression in Asthma Rats

针刺研究, 2014
Objective To observe the effect of acupuncture stimulation of"Dazhui"(GV 14),bilateral"Fengmen"(BL 12)and"Feishu"(BL 13)on the thickness of the bronchial tubal wall and smooth muscle and expression of transforming growth factor-β1(TGF-β1)in asthma rats ...
LI Hong-zhang, QIN Xiao-yan, SHAO Su-ju, HUA Jin-shuang   +3 more
doaj  

Asthma reconsidered: a cumulative data perspective on airway smooth muscle. [PDF]

ERJ Open Res
Reza MI, Sathish V.
europepmc   +1 more source

Hyperoxia and iron homeostasis in developing human airway smooth muscle. [PDF]

Am J Physiol Lung Cell Mol Physiol
Ortiz Y, Koloko Ngassie ML, Bartman CM, Pabelick CM, Prakash YS.   +4 more
europepmc   +1 more source

Long Non‐Coding RNA, Like NEAT1 and MALAT1, in Asthma: Mechanisms and Therapeutic Potential

Clinical &Experimental Allergy, EarlyView.
Long non‐coding RNA, like NEAT1 and MALAT1, is emerging as a regulator of asthma‐related inflammation, airway remodelling, viral responses and cell death pathways, and are promising targets for future therapeutics. ABSTRACT Asthma affects millions worldwide. Long non‐coding RNA (lncRNA) are emerging as important factors in the pathophysiology of asthma
Ashlyn Poole, Ingrid Laing, Ryan Mead‐Hunter, Peter Le Souef, Guicheng Zhang   +4 more
wiley   +1 more source

Molecular mechanisms underlying FCCP-induced mitophagy in human airway smooth muscle cells. [PDF]

Am J Physiol Lung Cell Mol Physiol
Mahadev Bhat S, Ramirez Ramirez OA, Sieck GC.   +2 more
europepmc   +1 more source

Human iPSC‐Derived Vascularised Lung Organoids for Modelling COPD and Pulmonary Hypertension

Cell Proliferation, EarlyView.
Vascularised lung organoids (vLOs) that faithfully mimic human lung tissue architecture and disease pathology are critical for advancing pulmonary research but remain challenging to generate. Here, we developed a robust self‐organisation protocol to produce vLOs with cellular heterogeneity and functional vasculature. The engineered blood vessels within
Simin Jiang, Liangliang Tian, Jingge Qu, Yi Hong, Dian Chen, Zihang Pan, Huanyu Long, Lanhe Chu, Weijing Kong, Qiyang Yao, Xiaojing Ma, Yun Zhao, Baihui Ma, Kai Wang, Yahong Chen   +14 more
wiley   +1 more source

Airway smooth muscle in asthma: insights from a transcriptomic meta-analysis. [PDF]

ERJ Open Res
Roy S, Mandal RS, Kurian S, Sharma P.
europepmc   +1 more source