Functional Evolution of Subolesin/Akirin [PDF]
Frontiers in Physiology, 2018 The Subolesin/Akirin constitutes a good model for the study of functional evolution because these proteins have been conserved throughout the metazoan and play a role in the regulation of different biological processes.
Sara Artigas-Jerónimo +9 more
doaj +14 more sources
Characterization of Akirin 2 gene in Langshan chicken [PDF]
Indian Journal of Animal Sciences, 2014 Akirin play an important role not only in innate immune response but also in skeletal myogenesis. The chicken’s Akirin gene family only has Akirin 2. We detected the coding sequences of the Akirin 2 gene in a Chinese indigenous chicken (Langshan chicken)
LINJUN YAN +4 more
doaj +3 more sources
Effects of Rhodotorula mucilaginosa on Growth, Antioxidant, and Immune Function, and Toll/Imd and JAK-STAT Signaling Pathways in Red Claw Crayfish (Cherax quadricanatus) [PDF]
Aquaculture NutritionIn aquaculture, the use of probiotics to improve growth, immunity, and stress resistance in crustaceans has gained increasing attention. This study examined the effects of incorporating different levels of Rhodotorula mucilaginosa (0.0, 0.1, 1.0, and 10 ...
Qin Zhang +9 more
doaj +3 more sources
Akirin links twist-regulated transcription with the Brahma chromatin remodeling complex during embryogenesis. [PDF]
PLoS Genetics, 2012 The activities of developmentally critical transcription factors are regulated via interactions with cofactors. Such interactions influence transcription factor activity either directly through protein-protein interactions or indirectly by altering the ...
Scott J Nowak +4 more
doaj +8 more sources
A Novel Combined Scientific and Artistic Approach for the Advanced Characterization of Interactomes: The Akirin/Subolesin Model [PDF]
Vaccines, 2020 The main objective of this study was to propose a novel methodology to approach challenges in molecular biology. Akirin/Subolesin (AKR/SUB) are vaccine protective antigens and are a model for the study of the interactome due to its conserved function in ...
José de la Fuente +2 more
exaly +9 more sources
Akirin/Subolesin regulatory mechanisms at host/tick-pathogen interactions. [PDF]
Microlife, 2022 Ticks and tick-borne pathogens such as Anaplasma phagocytophilum affect human and animal health worldwide and thus the characterization of host/tick–pathogen interactions is important for the control of tick-borne diseases.
de la Fuente J +2 more
europepmc +7 more sources
Evolutionary plasticity in the innate immune function of Akirin. [PDF]
PLoS Genetics, 2018 Eukaryotic gene expression requires the coordinated action of transcription factors, chromatin remodelling complexes and RNA polymerase. The conserved nuclear protein Akirin plays a central role in immune gene expression in insects and mammals, linking ...
Jolanta Polanowska +9 more
doaj +6 more sources
Akirin is critical for early tinman induction and subsequent formation of the heart in Drosophila melanogaster. [PDF]
Dev Biol, 2021 The regulation of formation of the Drosophila heart by the Nkx 2.5 homologue Tinman is a key event during embryonic development. In this study, we identify the highly conserved transcription cofactor Akirin as a key factor in the earliest induction of ...
Howard AM +5 more
europepmc +4 more sources
Evolution of the multifaceted eukaryotic
BMC Evolutionary Biology, 2009 Background Akirins are nuclear proteins that form part of an innate immune response pathway conserved in Drosophila and mice. This studies aim was to characterise the evolution of akirin gene structure and protein function in the eukaryotes.
Johnston Ian A, Macqueen Daniel J
doaj +5 more sources
Correction: Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila. [PDF]
PLoS Pathogens[This corrects the article DOI: 10.1371/journal.ppat.1008458.].
Alexandre Cammarata-Mouchtouris +9 more
doaj +2 more sources