Colocalization between Akirin, the NuRD Complex, and Histone Modifications [PDF]
, 2022 Akirin is a small highly conserved nuclear protein that has been of scientific interest since its discovery in 2008. Akirin functions as a transcriptional co-factor for many important biological pathways; however, detail regarding Akirin’s mechanism ...
Anglin, Sarah
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Akirin protein is broadly distributed throughout the genome.
, 2012 (A,B) Polytene chromosomes were prepared from wild-type larvae, immunostained with antibody against Akirin and counterstained with DAPI to visualize DNA.
Hitoshi Aihara (180458) +4 more
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The change in Akirin relative expression assessed 3-days post-RNAi treatment.
, 2020 The relative expression of Akirin was significantly downregulated by a mean factor of 0.76 (p = 0.02), when comparing the expression ratios between the Akirin dsRNA treated samples and the negative control samples.
Yael Dahan-Moss (4578901) +2 more
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Akirin colocalizes with subunits of the SWI/SNF-class Brahma chromatin remodeling complex.
, 2012 (A–C) Detail of polytene chromosome squashes demonstrating immunocolocalization of Akirin with Brm complex subunits. See Figure S9 for whole genome squash images.
Hitoshi Aihara (180458) +4 more
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Association of a single nucleotide polymorphism in akirin 2 gene with marbling in Japanese Black beef cattle [PDF]
BMC Research Notes, 2009 Marbling defined by the amount and distribution of intramuscular fat, so-called Shimofuri, is an economically important trait of beef cattle in Japan. The c17-25 expressed sequence tag (EST) has been previously shown to possess expression difference in musculus longissimus muscle between low-marbled and high-marbled steer groups, and to be located ...
Takahagi Youichi +10 more
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Analysis of novel heart defects in akirin mutants
, 2021 Among the metazoans the heart is one of the earliest discrete organ structures to form during embryogenesis, in a process highly conserved across the phyla.
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Akirin-Mediated Gene Regulation During Cardiac Development [PDF]
, 2015 The highly conserved nuclear protein Akirin was previously identified as a cofactor that modulates Twist transcription factor activity during muscle development in Drosophila melanogaster.
Howard, Austin M
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Akirin‐1 expression blocks dexmethosone induced satellite cell dysfunction
The FASEB Journal, 2013 Glucocorticoids are elevated in many pathological conditions and are associated with muscle loss, but the mechanisms are not fully understood. Defects in satellite cell function contribute to the development of muscle atrophy. Here, we demonstrated a new mechanism of dexamethasone‐induced muscle atrophy by suppression of satellite ...
Yanjun Dong +4 more
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Akirins are highly conserved nuclear proteins required for NF-κB-dependent gene expression in drosophila and mice [PDF]
Nature Immunology, 2007 During a genome-wide screen with RNA-mediated interference, we isolated CG8580 as a gene involved in the innate immune response of Drosophila melanogaster. CG8580, which we called Akirin, encoded a protein that acted in parallel with the NF-kappaB transcription factor downstream of the Imd pathway and was required for defense against Gram-negative ...
Tajima-Goto, Akira +9 more
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Investigating the molecular function of Akirin during skeletal myogenesis in Drosophila melanogaster [PDF]
, 2018 The specification and differentiation of muscle precursor cells, or myoblasts, by the action of the mesodermal and muscle transcription regulator Twist is a key event in the formation of the Drosophila larval musculature.
Rowland, Kristina
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