Results 41 to 50 of about 903,463 (268)
The surgery exact sequence, K-theory and the signature operator
, 2015 The main result of this paper is a new and direct proof of the natural transformation from the surgery exact sequence in topology to the analytic K-theory sequence of Higson and Roe.
Piazza, Paolo, Schick, Thomas
core +1 more source
Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells [PDF]
, 2018 Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular carcinoma. The current study evaluated cell signaling regulation of endoplasmic reticulum (ER) stress, c-Jun-N-terminal kinase (JNK)
Contreras Bernal, Laura +8 more
core +1 more source
On the intersection motive of certain Shimura varieties: the case of Siegel threefolds
, 2019 In this article, we construct a Hecke-equivariant Chow motive whose realizations equal intersection cohomology of Siegel threefolds with regular algebraic coefficients. As a consequence, we are able to define Grothendieck motives for Siegel modular forms.
Wildeshaus, J.
core +2 more sources
Iron-Induced Oxidative Injury Differentially Regulates PI3K/Akt/GSK3β Pathway in Synaptic Endings from Adult and Aged Rats [PDF]
, 2009 In this work we study the state of phosphoinositide-3-kinase/Akt/glycogen synthase kinase 3 beta (PI3K/Akt/GSK3 beta) signaling during oxidative injury triggered by free iron using cerebral cortex synaptic endings isolated from adult (4-month-old) and ...
Giusto, Norma Maria +2 more
core +2 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Cancer Biology & Therapy, 2022 The PI3K/Akt and Wnt/β-catenin pathways play an important role in the acquisition of the malignant phenotype in cancer. However, there are few data regarding the role of the interplay between both pathways in colorectal cancer (CRC) progression.
Cassio Dejair Fleming-de-Moraes +4 more
doaj +1 more source
On the K-theory of linear groups
, 2015 We prove that for a finitely generated linear group G over a field of positive characteristic the family of quotients by finite subgroups has finite asymptotic dimension.
Kasprowski, D.
core +2 more sources
Activation of Akt at T308 and S473 in alcohol, tobacco and HPV-induced HNSCC:is there evidence to support a prognostic or diagnostic role? [PDF]
, 2014 BACKGROUND: Tobacco, alcohol and HPV infection are associated with increased risk of HNSCC. However, little is known about the underlying signaling events influencing risk.
Cochrane, Lynda +4 more
core +3 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Cancer Biology & Therapy, 2022 Radiation resistance poses a major clinical challenge in breast cancer (BC) treatment, but little is known about how long noncoding RNA (lncRNA) may regulate this phenomenon. Here, we reported that DUXAP8 was highly expressed in radioresistant BC tissues,
Changjiang Lei +7 more
doaj +1 more source