Results 71 to 80 of about 196,626 (324)

Doxorubicin‐Loaded Metal–Organic Framework for Ferroptosis‐Enhanced Chemotherapy Through Sustained Zn Release and Glutathione Peroxidase Downregulation

Advanced Healthcare Materials, EarlyView.
A robust zinc‐based metal–organic framework (ZnMOF) enables dual functions of doxorubicin delivery and sustained Zn2+ release to trigger ferroptosis‐enhnaced chemotherapy. DOX@ZnMOF effectively depletes intracellular glutathione, suppresses GPX4, and elevates reactive oxygen species, leading to efficient oxidative DNA damage and apoptosis.
Xin Ma, Chenghua Deng, Chaoyu Wang, Langston Tilman, Jinhong Li, Wenbin Lin   +5 more
wiley   +1 more source

Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]

, 2011
Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez, Elke K. Markert, Zoltan N. Oltvai   +2 more
core   +2 more sources

Delivery of Multifunctional Microspheres via Intravesical Instillation for Bladder Carcinoma: Therapeutic Potential and Mechanistic Insights

Advanced Healthcare Materials, EarlyView.
PCTM microspheres were successfully synthesized using microfluidic and click chemistry techniques.In Vivo and in vitro experiments have shown that PCTM microspheres have obvious targeting, adhesion, membrane penetration and anti‐tumor properties for bladder tumors.The antitumor mechanism of PCTM microspheres is to indirectly induce S‐stage blockage of ...
Zhaoxiang Lu, Wentie Yang, Youzhi Hong, Yusen Qiao, Chaozhao Liang   +4 more
wiley   +1 more source

Gallbladder perforation during elective laparoscopic cholecystectomy: Incidence, risk factors, and outcomes

İstanbul Kuzey Klinikleri, 2018
INTRODUCTION[|]This study aimed to reveal the risk factors and outcomes of gallbladder perforation (GP) during laparoscopic cholecystectomy.[¤]METHODS[|]Videotapes of all patients who underwent an elective cholecystectomy at our department were ...
Yunus Emre Altuntas, Mustafa Oncel, Mustafa Haksal, Metin Kement, Ersin Gundogdu, Nihat Aksakal, Fazli Cem Gezen   +6 more
doaj   +1 more source

GLUCOCORTICOID STIMULATION OF THE BIOSYNTHESIS OF GLUTAMIC-ALANINE TRANSAMINASE [PDF]

Proceedings of the National Academy of Sciences, 1963
Results.-In order to interpret meaningfully the results of measurements of the influence of hormones on amino acid incorporation into a specific protein, it is necessary to know that the period of exposure to the labeled amino acid is short relative to the half-life of the enzyme.
H L, SEGAL, Y S, KIM
openaire   +2 more sources

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Sublethal Effects of Ternary Mixtures of Polycyclic Aromatic Hydrocarbons on Selected Liver Biomarkers of Clarias gariepinus

Journal of Applied Sciences and Environmental Management, 2023
The effect of ternary mixtures of polycyclic aromatic hydrocarbons in Clarias gariepinus was investigated. Apparently healthy juvenile fish (n = 90) weighing 19.7±1.8 g were exposed to sublethal concentrations of naphthalene, phenathrene and benzo[a ...
U. O. Osuagwu, C. O. Ujowundu, L. A. Nwaogu, R. N. Nwaoguikpe   +3 more
doaj   +1 more source

Pulse-Administered Toceranib Phosphate Plus Lomustine for Treatment of Unresectable Mast Cell Tumors in Dogs. [PDF]

, 2015
BackgroundNonresectable mast cell tumors (MCT) in dogs remain a therapeutic challenge, and investigation of novel combination therapies is warranted. Intermittent administration of tyrosine kinase inhibitors (TKI) combined with cytotoxic chemotherapy may
Avery, AC, Axiak-Bechtel, SM, Burton, JH, Clifford, CA, Thamm, DH, Vail, DM, Venable, RO, Williams, LE   +7 more
core   +1 more source

Engineered ETS1‐Nanoconjugate Restores Immune Homeostasis through Dual Immune‐Vascular Modulation in Relapsing and Progressive Multiple Sclerosis

Advanced Healthcare Materials, EarlyView.
The biomimetic nanoplatform IMNP (ETS1 pDNA/PBAE@ITP‐MM) undergoes targeted disassembly at inflammatory vascular sites to release the ETS1 plasmid (pETS1). This release initiates a cascade of effects that inhibit pathogenic pathways and support immune homeostasis. (Abbreviations: EndMT, endothelial‐to‐mesenchymal transition; EC, endothelial cell; TC, T
Feng Zhang, Si‐Bo Yang, Yan Luo, Xiao‐Di Sun, Bo‐Hao Chang, Da‐Qiang Zhou, Jun‐Jie Jiang, Ya‐Nan Li, Jie‐Hong Wu, Hui‐Juan Jin, Hang Yang, Hang Hu, Yi‐Fan Zhou, Bo Hu   +13 more
wiley   +1 more source

EFFICACY OF SALICYLIC AND ASCORBIC ACIDS TO REDUCE THE EFFECT OF TRANSPORT STRESS ON LIVE WEIGHT, SOME BLOOD CHARACTERISTICS AND INTESTINAL VILLI OF BROILER CHICKENS

The Iraqi Journal of Agricultural science, 2020
This experiment was conducted and aimed to reducing mortality and losing the weight of birds transported to the slaughter house through reducing or Transport stress removal and thus to reduce financial losses.
Al obaydy & et al.
doaj