Results 201 to 210 of about 13,748 (218)
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Alarmin Detection in Senescent Cells
2018Senescent cells secrete diverse array of proteins. One group of proteins, damage-associated molecular pattern (DAMP) proteins exhibit relocalization from inside to outside the cell. High Mobility Group Box 1 protein (HMGB1) is the founding DAMP member. HMGB1 relocalization from the nucleus provides a molecular signature during senescence.
Dong Eun, Kim, Albert R, Davalos
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Alarmins: chemotactic activators of immune responses
Current Opinion in Immunology, 2005The recruitment and activation of antigen-presenting cells are critical early steps in mounting an immune response. Many microbial components and endogenous mediators participate in this process. Recent studies have identified a group of structurally diverse multifunctional host proteins that are rapidly released following pathogen challenge and/or ...
Joost J, Oppenheim, De, Yang
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ApoC3: an ‘alarmin’ triggering sterile inflammation
Nature Immunology, 2019NLRP3-driven sterile inflammation facilitates the pathogenesis of various human inflammatory diseases. New work identifies apolipoprotein C3 as an endogenous NLRP3 agonist that promotes sterile inflammation and organ damage.
Tao Gong, Rongbin Zhou
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Alarmin’ lymphoid developments
Science SignalingThe alarmin cytokine IL-33 stimulates the formation of immune hubs within otherwise “cold” tumors.
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Endothelial Injury, Alarmins, and Allog raft Rejection
Critical Reviews™ in Immunology, 2008Allograft blood vessels are important targets of clinical allograft rejection. Perioperative allograft injury to graft vasculature, especially the endothelial cell (EC) lining, increases the risk of subsequent acute and chronic vascular rejection. We hypothesize that allograft EC injured by ischemia-reperfusion (I/R) during transplantation releases ...
Deepak A, Rao, Jordan S, Pober
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Is HMGB1 an osteocyte alarmin?
Journal of Cellular Biochemistry, 2007AbstractThe death of osteocytes, the terminally differentiated cells of the osteoblast lineage that are embedded in bone and regulate remodeling, is significant to both normal and pathological bone resorption. Apoptotic osteocytes putatively release a clarion signal that enhances the development of the bone‐resorbing osteoclasts and targets their ...
Joseph P, Bidwell +2 more
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The danger from within: alarmins in arthritis
Nature Reviews Rheumatology, 2016Alarmins (also known as danger signals) are endogenous molecules that are released to the extracellular milieu after infection or tissue damage. Extracellular alarmins interact with specific receptors expressed by cells that are engaged in host defence to stimulate signalling pathways that result in initiation of innate and adaptive immune responses ...
Meriam, Nefla +3 more
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Harnessing the Alarmin HMGN1 for Anticancer Therapy
Immunotherapy, 2015Incipient cancer cells formed as a result of mutations of oncogene(s), tumor suppressor gene(s) and/or DNA repair gene(s) develop into malignant tumors depending on three processes. They acquire a higher rate of mutation due to increased sensitivity to endogenous and exogenous mutagenic agents or due to a breakdown in one or several components of the ...
De, Yang +2 more
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[Alarmins and surgical injury].
Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, 2019Surgical intervention is an inseparable part of the management of serious surgical disease. However, surgery also presents a potential risk related to the so-called surgical injury causing immune response. When dysregulated the immune activation is able to cause local complications (i.e. wound dehiscence, impaired healing).
J, Máca, M, Peteja
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