Results 201 to 210 of about 13,578 (213)
Some of the next articles are maybe not open access.
Is HMGB1 an osteocyte alarmin?
Journal of Cellular Biochemistry, 2007AbstractThe death of osteocytes, the terminally differentiated cells of the osteoblast lineage that are embedded in bone and regulate remodeling, is significant to both normal and pathological bone resorption. Apoptotic osteocytes putatively release a clarion signal that enhances the development of the bone‐resorbing osteoclasts and targets their ...
Joseph P, Bidwell +2 more
openaire +2 more sources
The danger from within: alarmins in arthritis
Nature Reviews Rheumatology, 2016Alarmins (also known as danger signals) are endogenous molecules that are released to the extracellular milieu after infection or tissue damage. Extracellular alarmins interact with specific receptors expressed by cells that are engaged in host defence to stimulate signalling pathways that result in initiation of innate and adaptive immune responses ...
Meriam, Nefla +3 more
openaire +2 more sources
Harnessing the Alarmin HMGN1 for Anticancer Therapy
Immunotherapy, 2015Incipient cancer cells formed as a result of mutations of oncogene(s), tumor suppressor gene(s) and/or DNA repair gene(s) develop into malignant tumors depending on three processes. They acquire a higher rate of mutation due to increased sensitivity to endogenous and exogenous mutagenic agents or due to a breakdown in one or several components of the ...
De, Yang +2 more
openaire +2 more sources
[Alarmins and surgical injury].
Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, 2019Surgical intervention is an inseparable part of the management of serious surgical disease. However, surgery also presents a potential risk related to the so-called surgical injury causing immune response. When dysregulated the immune activation is able to cause local complications (i.e. wound dehiscence, impaired healing).
J, Máca, M, Peteja
openaire +1 more source