A shared alarmone-GTP switch underlies triggered and spontaneous persistence
Abstract Persisters describe phenotypically switched cells refractory to antibiotic killing in a genetically susceptible population, while preserving the ability to resume growth when antibiotics are discontinued1,2. Since its proposal 70 years ago, great strides were made to build the framework regarding persistence, including defining ...
Jue Wang +8 more
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ppGpp functions as an alarmone in metazoa
ppGpp functions as an alarmone in metazoaidentifier:oai:t2r2.star.titech.ac.jp ...
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Study of Atypical Alarmone Synthesis in Clostridioides difficile
Clostridioides difficile is a Gram-positive anaerobic bacterium that causes infections in humans that costs healthcare systems billions per year. C. difficile infection has high rates of recurrence due to multiple antibiotic resistance. When bacteria are in stressful environments, they produce hyperphosphorylated guanosine ribonucleotide signaling ...
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The Importance of Microorganisms for Sustainable Agriculture-A Review. [PDF]
Metabolites, 2022 Antoszewski M +2 more
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Increased Levels of (p)ppGpp Correlate with Virulence and Biofilm Formation, but Not with Growth, in Strains of Uropathogenic Escherichia coli. [PDF]
Int J Mol Sci, 2023 Karczewska M +5 more
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Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp. [PDF]
FEBS LettZegarra V +7 more
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Editorial: Microbial sensing to control host immune responses. [PDF]
Front Microbiol, 2022 Sayed IM, Bhattacharyya A, Das S.
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Awakening sleeper cells: a narrative review on bacterial magic spot synthetases as potential drug targets to overcome persistence. [PDF]
Curr Genet, 2022 Veetilvalappil VV +3 more
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Bacterial nucleosidase is regulated by the alarmone (p)ppGpp [PDF]
Acta Crystallographica Section A Foundations and Advances, 2019 openaire +1 more source
Microbial Primer: what is the stringent response and how does it allow bacteria to survive stress? [PDF]
Microbiology (Reading)Urwin L, Savva O, Corrigan RM.
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