Results 71 to 80 of about 748 (149)

Nanobody-mediated control of long RSH Rel and RelA catalysis by restriction of their conformational landscape

Nature Communications
Long RSH enzymes, Rel and RelA, are master regulators of bacterial (p)ppGpp alarmones levels. Bifunctional Rel transitions between a compact hydrolysis-competent (HDON) state, a relaxed catalytically inactive (HDOFF/SYNTHOFF) state, and an elongated ...
Katleen Van Nerom, Andres Ainelo, Kyo Coppieters ‘t Wallant, Ariel Talavera-Perez, Dannele Echemendia-Blanco, Sarah Peeters, Brahim El Khalfaoui Oulali, Hedvig Tamman, Tatsuaki Kurata, Mohammad Roghanian, Chloé Martens, Els Pardon, Jan Steyaert, Vasili Hauryliuk, Abel Garcia-Pino   +14 more
doaj   +1 more source

Catalytic Mechanism and Differential Alarmone Regulation of a Conserved Stringent Nucleosidase

Structure
ABSTRACT Understanding how bacteria rapidly adapt their metabolism in response to external stimuli is key to addressing the present crisis of antibiotics-resistant infections. In the Gram-negative bacterium Escherichia coli , the universal stringent response is elicited in response ...
René L. Bærentsen, Kristina Kronborg, Ditlev E Brodersen, Yong E. Zhang   +3 more
openaire   +3 more sources

Structural studies of bacterial small alarmone hydrolases [PDF]

Acta Crystallographica Section A Foundations and Advances, 2021
Adriana Chrenková, Francesco Bisiak, Ditlev Egeskov Brodersen   +2 more
openaire   +1 more source

Molecular mechanisms of alarmones during bacterial stress responses

, 2023
In the incessant effort of living and propagating, bacterial cells cope with environmental stress via the release of second messengers and/or alarmones that allow them to adapt swiftly. Such molecules are nucleotidebased and can be promptly generated when stress stimuli occur.
openaire   +2 more sources

Action of the bacterial alarmones (p)ppGpp on translational GTPases

, 2022
Zusammenfassung Ribosomen sind hoch komplexe Makromoleküle, deren vollständige Assemblierung in funktionale Einheiten eine Vielzahl von akzessorischen Proteinen und Faktoren bedingt. Viele dieser Maturierungsfaktoren gehören der Proteinfamilie der GTPasen an.
openaire   +2 more sources

A shared alarmone–GTP switch controls persister formation in bacteria

Nature Microbiology
Abstract Persisters are phenotypically switched bacteria that survive antibiotic exposure despite being genetically susceptible. Three pathways to persistence—triggered, spontaneous and antibiotic-induced—have been described, but the underlying molecular mechanisms are poorly understood.
Danny K. Fung, Jessica T. Barra, Jin Yang, Jeremy W. Schroeder, Fukang She, Megan Young, David Ying, David M. Stevenson, Daniel Amador-Noguez, Jue D. Wang   +9 more
openaire   +2 more sources

Sound the (Smaller) Alarm: The Triphosphate Magic Spot Nucleotide pGpp. [PDF]

Infect Immun, 2023
Malik A, Hept MA, Purcell EB.
europepmc   +1 more source

Crosstalk between (p)ppGpp and other nucleotide second messengers. [PDF]

Curr Opin Microbiol, 2023
Fung DK, Trinquier AE, Wang JD.
europepmc   +1 more source

A dual program for CRP-mediated regulation in bacterial alarmone (p)ppGpp

mBio
ABSTRACT Gene expression and proper downstream cellular functions upon facing environmental shifts depend on the combined and cooperative regulation of genetic networks. Here, we identified cAMP receptor protein (CRP) as a master regulator of (p)ppGpp (guanosine tetra- and penta-phosphate) homeostasis.
Li Zhao, Shi-Yu Zhou, Yu Fu, Jin-Long Shen, Bin-Cheng Yin, Di You, Bang-Ce Ye   +6 more
openaire   +3 more sources

(p)ppGpp - an important player during heat shock response. [PDF]

Microlife, 2023
Driller K, Cornejo FA, Turgay K.
europepmc   +1 more source