Results 51 to 60 of about 748 (149)
SpoT Induces Intracellular
mBio, 2020 Guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), together named (p)ppGpp, regulate diverse aspects of Salmonella pathogenesis, including synthesis of nutrients, resistance to inflammatory mediators, and expression of secretion ...
Liam F. Fitzsimmons +8 more
doaj +1 more source
De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence
MicrobiologyOpen, Volume 15, Issue 4, August 2026.Bacterial pathogens survive in different host environments by switching between making nucleotides by de novo synthesis and scavenging them from the host. This flexibility supports growth and virulence making nucleotide metabolism an attractive therapeutic target.
Riya Joshi +2 more
wiley +1 more source
Proteomic Analysis of Lactococcus lactis FM03 Under Prolonged Alkaline Stress
Environmental Microbiology, Volume 28, Issue 7, July 2026.Overview of alkaline resistance mechanisms in Lactococcus lactis FM03. Sustained growth at pH 8 triggers extensive physiological remodelling, including activation of general stress response proteins, suppression of acid resistance, elevated amino acid production, altered cell wall biosynthesis, and doubling of the cell wall thickness.
Tamara A. L. Bendig +4 more
wiley +1 more source
Ontogenetic Sequence of Differential Gene Expression in Predator‐Induced Daphnia pulex
Molecular Ecology, Volume 35, Issue 13, July 2026.ABSTRACT In response to predators, many Daphnia species develop inducible morphological defenses. These traits are phenotypically plastic, meaning their production is suppressed in the absence of the predator. While previous studies have identified several neurohumoral factors and candidate genes involved in the development of the defenses, the ...
Andrey Rozenberg +5 more
wiley +1 more source
Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing
Advanced Science, Volume 13, Issue 33, 15 June 2026.Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu +7 more
wiley +1 more source
Transcription of photosynthetic genes in the plant chloroplast: lessons from bacteria
The Plant Journal, Volume 126, Issue 5, June 2026.SUMMARY The RNA polymerase that transcribes photosynthetic genes in the plant chloroplast is the largest known transcription enzyme across all domains of life, comprising 21 subunits of bacterial and eukaryotic origin. Recent structural analyses revealed that the core polymerase, inherited from the cyanobacterial ancestor of the chloroplast, is encased
Jessica Moon +5 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 15, 6 April 2026.We synthesized photocaged, clickable and isotope‐labeled “magic spot” Nucleotides and delivered them into Escherichia coli comparing different approaches. Light‐controlled release inside living cells enabled tracking of their conversion from pppGpp to ppGpp by capillary electrophoresis mass spectrometry and revealed their impact on the growth rate of a
Christoph Popp +12 more
wiley +1 more source
Identification and Functional Characterization of Small Alarmone Synthetases in Corynebacterium glutamicum [PDF]
Frontiers in Microbiology, 2017 The hyperphosphorylated guanosine derivatives ppGpp and pppGpp represent global regulators of the bacterial stress response, as they act as central elements of the stringent response system. Although it was assumed that both, (p)ppGpp synthesis and hydrolysis, are catalyzed by one bifunctional RSH-protein in the actinobacterial model organism ...
Ruwe, Matthias +2 more
openaire +4 more sources
Frontiers in Microbiology, 2019 The alarmone species ppGpp and pppGpp are elementary components of bacterial physiology as they both coordinate the bacterial stress response and serve as fine-tuners of general metabolism during conditions of balanced growth.
Matthias Ruwe +4 more
doaj +1 more source
Microbial Biotechnology, Volume 19, Issue 4, April 2026.The AUCS70/AUCS100 ratio, derived from ribosome sedimentation profiling, quantitatively distinguishes Escherichia coli persisters from growing cells across multiple stress conditions and identifies RMF as the primary target for anti‐persistence strategies. ABSTRACT Persister cells survive antibiotic exposure and contribute to infection relapse, yet the
Hyein Kim, Sooyeon Song
wiley +1 more source