Results 41 to 50 of about 748 (149)

Small Alarmone Synthetases as novel bacterial RNA-binding proteins [PDF]

RNA Biology, 2017
The alarmone nucleotides guanosine pentaphosphate (pppGpp) and tetraphosphate (ppGpp), collectively referred to as (p)ppGpp, are key regulators of bacterial growth, stress adaptation, antibiotic tolerance and pathogenicity. We have recently shown that the Small Alarmone Synthetase (SAS) RelQ from the Gram-positive pathogen Enterococcus faecalis has an ...
Vasili, Hauryliuk, Gemma C, Atkinson
openaire   +2 more sources

Metabolic aspects of bacterial persisters

Frontiers in Cellular and Infection Microbiology, 2014
Persister cells form a multi-drug tolerant subpopulation within an isogenic culture of bacteria that are genetically susceptible to antibiotics. Studies with different Gram negative and Gram positive bacteria have identified a large number of genes ...
Marcel ePrax, Ralph eBertram
doaj   +1 more source

Activation of a zinc metallochaperone by the alarmone ZTP [PDF]

, 2019
Abstract Bacteria tightly regulate intracellular zinc levels to ensure sufficient zinc to support essential functions, while preventing toxicity. The bacterial response to zinc limitation includes the expression of putative zinc metallochaperones belonging to subfamily 1 of the COG0523 family of G3E GTPases.
Chandrangsu, Pete, Huang, Xiaojuan, Helmann, John D.   +2 more
openaire   +1 more source

Direct binding targets of the stringent response alarmone (p)ppGpp [PDF]

Molecular Microbiology, 2012
SummaryThe Escherichia coli stringent response, mediated by the alarmone ppGpp, is responsible for the reorganization of cellular transcription upon nutritional starvation and other stresses. These transcriptional changes occur mainly as a result of the direct effects of ppGpp and its partner transcription factor DksA on RNA polymerase.
Usheer, Kanjee, Koji, Ogata, Walid A, Houry   +2 more
openaire   +2 more sources

How the initiating ribosome copes with ppGpp to translate mRNAs.

PLoS Biology, 2020
During host colonization, bacteria use the alarmones (p)ppGpp to reshape their proteome by acting pleiotropically on DNA, RNA, and protein synthesis. Here, we elucidate how the initiating ribosome senses the cellular pool of guanosine nucleotides and ...
Daria S Vinogradova, Victor Zegarra, Elena Maksimova, Jose Alberto Nakamoto, Pavel Kasatsky, Alena Paleskava, Andrey L Konevega, Pohl Milón   +7 more
doaj   +1 more source

Twenty‐Five Years of the Environmental Stress Response and the Enduring Power of Yeast in Stress Biology

Yeast, EarlyView.
ABSTRACT All organisms must be able to sense and respond to adverse environments, especially those that threaten cellular integrity. The age of genomics clarified the breadth and specificity of cellular stress responses, including in free‐living microbes directly exposed to a changing environment.
Audrey P. Gasch
wiley   +1 more source

A Single‐Nucleotide Substitution Generates a de Novo Promoter That Activates a Latent Metabolic Bypass in Escherichia coli

Molecular Microbiology, EarlyView.
A chromosomal mutation allows bypass of deletion of the Escherichia coli fabH gene. The bypass results from creation of a new promoter that drives increased madA transcription, resulting in increased synthesis of acetyl‐acyl carrier protein by decarboxylation of malonyl‐acyl carrier protein.
Qiaoqiao Guo, Qi Zou, Jilong Qin, Makrina Totsika, Yaoqin Hong, John E. Cronan   +5 more
wiley   +1 more source

Structural and functional insights into Pseudomonas aeruginosa ApaH, a diadenosine tetraphosphatase crucial for bacterial virulence

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Infections by Pseudomonas aeruginosa are a major cause of severe morbidity and mortality in immunocompromised patients and people with cystic fibrosis, largely due to the pathogen's ability to resist antibiotic treatment and to deploy multiple virulence strategies that promote persistence in the host.
Gianluca Pistoia, Matteo Cervoni, Flavia Catalano, Francesca Troilo, Francesca Guidi, Eleonora Comparini, Giuseppina Mignogna, Carlo Travaglini‐Allocatelli, Alessandro Giuffrè, Antonio Coluccia, Francesco Imperi, Adele Di Matteo, Giorgio Giardina   +12 more
wiley   +1 more source

Np ₄ A alarmones function in bacteria as precursors to RNA caps [PDF]

Proceedings of the National Academy of Sciences, 2020
Significance Since their discovery more than 50 years ago, dinucleoside tetraphosphates have been found in all realms of life, at levels correlated with a variety of intriguing physiological changes. However, their molecular mechanism of action has largely remained an enigma.
Daniel J, Luciano, Joel G, Belasco
openaire   +2 more sources

The Impact of the Stringent Response on TRAFAC GTPases and Prokaryotic Ribosome Assembly

Cells, 2019
Many facets of ribosome biogenesis and function, including ribosomal RNA (rRNA) transcription, 70S assembly and protein translation, are negatively impacted upon induction of a nutrient stress-sensing signalling pathway termed the stringent response ...
Daniel J. Bennison, Sophie E. Irving, Rebecca M. Corrigan   +2 more
doaj   +1 more source