Results 61 to 70 of about 748 (149)

Bacteriophage Therapy: Current Strategies and Future Perspectives

MedComm, Volume 7, Issue 3, March 2026.
This manuscript systematically reviews the expanding scope of phage applications. It moves beyond traditional antibacterial use to explore their role in precision therapies against drug‐resistant infections, their synergy with antibiotics, and advanced biomaterial‐assisted delivery systems.
Zihe Zhou, Hanyu Fu, Mengzhe Li, Zhongyu Han, Zhenchao Wu, Huahao Fan, Ning Shen, Jiajia Zheng   +7 more
wiley   +1 more source

Virulence Regulation and Lifestyle Transitions: The Role of c‐di‐GMP and Two‐Component Systems in Erwinia amylovora and Their Evolutionary Context Within Enterobacterales

Molecular Plant Pathology, Volume 27, Issue 2, February 2026.
Erwinia amylovora infects apple blossoms by activating the T3SS, then spreads systemically via amylovoran‐mediated biofilms. Transitions between motile and sessile states are regulated by key two‐component systems and c‐di‐GMP. This review summarises infection biology, virulence factors, regulatory networks and evolutionary insights underlying fire ...
Dhirendra Niroula, Kalyani Bhandari, George W. Sundin, Janak R. Joshi   +3 more
wiley   +1 more source

Emerging Threat of Vibrio alginolyticus in Mediterranean Aquaculture: Virulence, Antibiotic Resistance, and Innovative Control Strategies

Aquaculture Research, Volume 2026, Issue 1, 2026.
Vibrio alginolyticus is an opportunistic marine pathogen increasingly associated with disease outbreaks in Mediterranean aquaculture, affecting fish, shrimp, and shellfish. The semi‐enclosed nature of the Mediterranean Sea, combined with rising seawater temperatures and intensive farming practices, creates favorable conditions for the persistence and ...
Rim Lajnef, Sara Thabet, Lotfi Ben Abdallah   +2 more
wiley   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Metabolic Origin, Role and Fate of the Denaturant Guanidine

Microbial Biotechnology, Volume 18, Issue 11, November 2025.
The origin of metabolic guanidine is largely a mystery. We suggest it is created when guanine‐containing nucleotides are oxidised by molecular oxygen instead of being broken down into urea as purines normally would. Guanidine may act as a signal to help cells control the level of reactive oxygen species.
Antoine Danchin, Victor de Lorenzo, Pablo Iván Nikel, Conghui You   +3 more
wiley   +1 more source

The τ of alarmone hydrolysis

Nature Chemical Biology, 2022
Danny K. Fung, Jue D. Wang
openaire   +3 more sources

The ancient alarmone ZTP and zinc homeostasis in Bacillus subtilis [PDF]

Molecular Microbiology, 2019
SummaryIn Bacillus subtilis a sophisticated regulatory circuit that involves Z nucleoside triphosphate (ZTP) is recruited to optimize cellular zinc distribution when cytoplasmic zinc is scarce. This process uses enzymatic reactions to measure the pool of available zinc ions and amplifies this signal to control the activity of zinc chaperones.
openaire   +2 more sources

Dinucleoside Polyphosphates in Cellular Signaling: Function and Evolution Across Life

BioEssays, Volume 47, Issue 10, October 2025.
Although discovered more than 50 years ago, the cellular functions of Ap4A and related dinucleotides remain largely enigmatic. To address this knowledge gap, we organized a conference showcasing recent research that highlights the critical role of Ap4A as a global regulator across all domains of life.
Gert Bange, Jennifer N. Andexer, Henning J. Jessen, Johannes Freitag, Sonja‐Verena Albers, Jan Pané‐Farré   +5 more
wiley   +1 more source

Xanthomonas campestris utilizes IAA to regulate its viability and virulence by altering the production of BCAAs and ROS

mLife, Volume 4, Issue 5, Page 551-566, October 2025.
Abstract Indole‐3‐acetic acid (IAA) is an important plant hormone that regulates a variety of physiological processes in plants, and it is also produced by some microbes. However, the biosynthesis and roles of IAA in microorganisms, particularly in plant pathogens, remain to be determined.
Sinan Li, Kai Song, Ying Cui, Lin Li, Minglei Zhang, Ya‐Wen He   +5 more
wiley   +1 more source

Staphylococcus aureus COL: An Atypical Model Strain of MRSA That Exhibits Slow Growth and Antibiotic Tolerance due to a Mutation in PRPP Synthetase

Molecular Microbiology, Volume 124, Issue 3, Page 189-203, September 2025.
COL is an unusual “model” strain of Staphylococcus aureus that exhibits slow growth and multidrug antibiotic tolerance. This phenotype is primarily due to a mutation in Prs, which synthesizes the core metabolite phosphoribosyl pyrophosphate (PRPP). Introduction of the COL Prs allele into the antibiotic‐susceptible strain Newman confers tolerance, while
Claire E. Stevens, Ashley T. Deventer, Paul R. Johnston, Phillip T. Lowe, Alisdair B. Boraston, Joanne K. Hobbs   +5 more
wiley   +1 more source