Results 31 to 40 of about 748 (149)
Control of transcription elongation and DNA repair by alarmone ppGpp
Nature Structural & Molecular Biology, 2023 AbstractSecond messenger (p)ppGpp (collectively guanosine tetraphosphate and guanosine pentaphosphate) mediates bacterial adaptation to nutritional stress by modulating transcription initiation. More recently, ppGpp has been implicated in coupling transcription and DNA repair; however, the mechanism of ppGpp engagement remained elusive. Here we present
Jacob W. Weaver +9 more
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Clinical rel mutations in Staphylococcus aureus prime pathogen expansion under nutrient stress
mSphere, 2023 Persistent infection by Staphylococcus aureus has been linked to the bacterial stringent response (SR), a conserved stress response pathway regulated by the Rel protein.
Edwin Chen +6 more
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Microbiology Spectrum, 2022 Pasteurella multocida is a Gram-negative capsulated bacterium responsible for a range of diseases that cause severe morbidity and mortality in livestock animals. The hyaluronic acid (HA) capsule produced by P.
Thomas R. Smallman +3 more
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Induction of the Stringent Response Underlies the Antimicrobial Action of Aliphatic Isothiocyanates
Frontiers in Microbiology, 2021 Bacterial resistance to known antibiotics comprises a serious threat to public health. Propagation of multidrug-resistant pathogenic strains is a reason for undertaking a search for new therapeutic strategies, based on newly developed chemical compounds ...
Dariusz Nowicki +5 more
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Amino Acid Starvation-Induced Glutamine Accumulation Enhances Pneumococcal Survival
mSphere, 2023 Bacteria are known to cope with amino acid starvation by the stringent response signaling system, which is mediated by the accumulation of the (p)ppGpp alarmones when uncharged tRNAs stall at the ribosomal A site.
Chengwang Zhang +8 more
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mBio, 2021 During nutrient limitation, bacteria produce the alarmones (p)ppGpp as effectors of a stress signaling network termed the stringent response. RsgA, RbgA, Era, and HflX are four ribosome-associated GTPases (RA-GTPases) that bind to (p)ppGpp in ...
Daniel J. Bennison +5 more
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Bio-Protocol, 2016 The stringent response in bacteria is a stress response that is mediated by the signaling molecules guanosine tetraphosphate and pentaphosphate [(p)ppGpp], alarmones that are also directly related to virulence. Therefore, determination of (p)ppGpp levels
Smitha Sivapragasam, Anne Grove
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The synthesis and function of the alarmone (p)ppGpp in firmicutes
International Journal of Medical Microbiology, 2010 In most bacteria, nutrient limitations provoke the stringent control by the rapid synthesis of the alarmones pppGpp and ppGpp. The most prominent and highly conserved reaction is the repression of rRNA synthesis. Additionally, (p)ppGpp synthesis is also linked to many other physiological changes involving gene activation/repression but also protein ...
Christiane, Wolz +2 more
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Alarmone Ap4A is elevated by aminoglycoside antibiotics and enhances their bactericidal activity [PDF]
Proceedings of the National Academy of Sciences, 2019 Significance This paper demonstrates that aminoglycoside antibiotics induce the production of the Ap4A in bacteria. Increased intracellular Ap4A, in turn, promotes bacterial cell killing by this class of antibiotics, which correlated well with elevated damage to the bacterial membrane upon aminoglycoside treatment.
Xia Ji +8 more
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Stringent response governs the oxidative stress resistance and virulence of Francisella tularensis.
PLoS ONE, 2019 Francisella tularensis is a Gram-negative bacterium responsible for causing tularemia in the northern hemisphere. F. tularensis has long been developed as a biological weapon due to its ability to cause severe illness upon inhalation of as few as ten ...
Zhuo Ma +7 more
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