Results 11 to 20 of about 748 (149)
Direct detection of stringent alarmones (pp)pGpp using malachite green [PDF]
Microbial CellThe alarmone (p)ppGpp serves as the signalling molecule for the bacterial universal stringent response and plays a crucial role in bacterial virulence, persistence, and stress adaptation. Consequently, there is a significant focus on developing new drugs
Muriel Schicketanz +5 more
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DMNP, a Synthetic Analog of Erogorgiaene, Inhibits the ppGpp Synthetase Activity of the Small Alarmone Synthetase RelZ [PDF]
BIO Web of Conferences, 2023 Suppression of the stringent response is a promising strategy for the treatment of persistent bacterial infections. A novel class of compounds having a mechanism of action based on alarmone synthetase inhibition and suppressing the synthesis of (p)ppGpp ...
Sidorov Roman Yu. +1 more
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The Ps and Qs of alarmone synthesis in Staphylococcus aureus.
PLoS ONE, 2019 During the stringent response, bacteria synthesize guanosine-3',5'-bis(diphosphate) (ppGpp) and guanosine-5'-triphosphate 3'-diphosphate (pppGpp), which act as secondary messengers to promote cellular survival and adaptation.
Ning Yang +5 more
doaj +4 more sources
Targeting the bacterial stringent response to combat human pathogens [PDF]
Frontiers in ImmunologyIn the era of increasing bacterial antibiotic resistance, finding new ways of combating pathogens is especially important. An attractive possibility is targeting bacterial survival strategies that microorganisms employ either to evade the host immune ...
Filip Gąsior +3 more
doaj +2 more sources
ppGpp functions as an alarmone in metazoa [PDF]
Communications Biology, 2019 Abstract Guanosine 3’,5’-bis(pyrophosphate) (ppGpp) functions as a second messenger in bacteria to adjust their physiology in response to environmental changes. In recent years, the ppGpp-specific hydrolase, metazoan SpoT homolog-1 (Mesh1), was shown to have important roles for growth under nutrient deficiency in
Doshun Ito +9 more
openaire +2 more sources
Frontiers in Microbiology, 2020 (p)ppGpp is a highly conserved bacterial alarmone which regulates many aspects of cellular physiology and metabolism. In Gram-positive bacteria such as B.
Danny K. Fung +4 more
doaj +1 more source
The Alarmone Diadenosine Tetraphosphate as a Cosubstrate for Protein AMPylation
Angewandte Chemie International Edition, 2023 AbstractDiadenosine polyphosphates (ApnAs) are non‐canonical nucleotides whose cellular concentrations increase during stress and are therefore termed alarmones, signaling homeostatic imbalance. Their cellular role is poorly understood. In this work, we assessed ApnAs for their usage as cosubstrates for protein AMPylation, a post‐translational ...
Matthias Frese +6 more
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(p)ppGpp: Magic Modulators of Bacterial Physiology and Metabolism
Frontiers in Microbiology, 2020 When bacteria experience growth-limiting environmental conditions, the synthesis of the hyperphosphorylated guanosine derivatives (p)ppGpp is induced by enzymes of the RelA/SpoT homology (RSH)-type protein family. High levels of (p)ppGpp induce a process
Wieland Steinchen +2 more
doaj +1 more source
The two PPX-GppA homologues from Mycobacterium tuberculosis have distinct biochemical activities. [PDF]
PLoS ONE, 2012 Inorganic polyphosphate (poly-P), guanosine pentaphosphate (pppGpp) and guanosine tetraphosphate (ppGpp) are ubiquitous in bacteria. These molecules play a variety of important physiological roles associated with stress resistance, persistence, and ...
Mei Y Choi +7 more
doaj +1 more source
Unique Features of Alarmone Metabolism in Clostridioides difficile
Journal of Bacteriology, 2022 Despite the role of the stringent response in antibiotic survival and recurrent infections, it has been a challenging target for antibacterial therapies because it is so ubiquitous. This is an especially relevant consideration for the treatment of Clostridioides difficile infection (CDI), as exposure to broad ...
Asia Poudel +8 more
openaire +3 more sources