Results 51 to 60 of about 1,499,988 (310)

Albumin concentrations are primarily determined by the body cell mass and the systemic inflammatory response in cancer patients with weight loss [PDF]

, 2001
The association between hypoalbuminemia and poor prognosis in patients with cancer is well recognized. However, the factors that contribute to the fall in albumin concentrations are not well understood.
Colin S. McArdle, Donald C. McMillan, Fearon KCH, Hazel R. Scott, Kotler DP, McMillan DC, McMillan DC, Micozzi MS, O'Gorman P, Patricia O'Gorman, Preston T, Schneider SM, Tom Preston, Walter S. Watson, Watson WS   +14 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Efficacy of albumin use in decompensated cirrhosis and real‐world adoption in Australia

JGH Open
The current treatment approach to patients with liver cirrhosis relies on the individual management of complications. Consequently, there is an unmet need for an overall therapeutic strategy for primary and secondary prevention of complications.
Eric Kalo, Scott Read, Asma Baig, Kate Marshall, Wai‐See Ma, Helen Crowther, Cameron Gofton, Kate D Lynch, Siddharth Sood, Jacinta Holmes, John Lubel, Alan Wigg, Geoff McCaughan, Stuart K Roberts, Paolo Caraceni, Golo Ahlenstiel, Avik Majumdar   +16 more
doaj   +1 more source

Affected albumin endocytosis as a new neurotoxicity mechanism of amyloid beta

AIMS Neuroscience, 2020
Senile plaques, a hallmark of Alzheimer's disease, are composed by Amyloid-Beta (Aβ). Aβ 25-35 toxicity is caused mainly by increasing reactive oxygen species (ROS), which is reversed by albumin preventing Aβ internalization.
Lourdes A. Vega Rasgado, Arantxa Tabernero Urbieta, José María Medina Jiménez   +2 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Blood urea nitrogen-to-albumin ratio as a new prognostic indicator of 1-year all-cause mortality in patients with IPF

Frontiers in Medicine
BackgroundIdiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by chronic inflammation and progressive fibrosis. The blood urea nitrogen-to-albumin ratio (BAR) is a comprehensive parameter associated with inflammation status;
Shaobo Ge, Yuer Li, Rui Li, Jin Liu, Rui Zhang, Hongyan Fu, Jingjing Tang, Jie Zhang, Nali Zhang, Ming Zhang, Ming Zhang   +10 more
doaj   +1 more source

C-Reactive Protein/Albumin Ratio Correlates With Disease Severity and Predicts Outcome in Patients With Aneurysmal Subarachnoid Hemorrhage

Frontiers in Neurology, 2019
Aim: The purpose of the present study was to determine if C-reactive protein (CRP)/albumin ratio was associated with disease severity and unfavorable outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH).Methods: One hundred and twenty-three
Dingding Zhang, Huiying Yan, Yongxiang Wei, Xiangyu Liu, Zong Zhuang, Wei Dai, Jinsong Li, Wei Li, Chunhua Hang   +8 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Decision-making in wildlife forensics: comparing complex and simple cases at the Wyoming Game and Fish Laboratory

Frontiers in Ecology and Evolution
This study compares the decision-making processes and workflows of complex and simple wildlife forensic cases at the Wyoming Game and Fish Wildlife Forensic Laboratory.
Kimberly M. Frazier, Tasha L. Bauman
doaj   +1 more source

Serum Free Light Chains Removal by HFR Hemodiafiltration in Patients with Multiple Myeloma and Acute Kidney Injury. a Case Series [PDF]

, 2018
Background/Aims: Multiple myeloma (MM) represents 10% of all haematologic malignancies. Renal involvement occurs in 50% of MM patients; of them, 12-20% have acute kidney injury (AKI), with 10% needing dialysis at presentation. While hemodialysis (HD) has
Antolino, Giusy, Festuccia, Francescaromana, Fofi, Claudia, Giammarioli, Elisa, La Verde, Giacinto, Mene, Paolo, Punzo, Giorgio, Tafuri, Agostino   +7 more
core   +2 more sources