Results 51 to 60 of about 1,730,986 (402)
Albumin-based drug delivery: harnessing nature to cure disease
Molecular and Cellular Therapies, 2016 The effectiveness of a drug is dependent on accumulation at the site of action at therapeutic levels, however, challenges such as rapid renal clearance, degradation or non-specific accumulation requires drug delivery enabling technologies.
M. Larsen +3 more
semanticscholar +1 more source
Albumin uptake in human podocytes: a possible role for the cubilin-amnionless (CUBAM) complex [PDF]
, 2017 Albumin re-uptake is a receptor-mediated pathway located in renal proximal tubuli. There is increasing evidence of glomerular protein handling by podocytes, but little is known about the mechanism behind this process.
ANGLANI, FRANCA +8 more
core +1 more source
Effect of anti-retroviral therapy on oxidative stress in hospitalized HIV-infected adults with and without TB. [PDF]
, 2018 BackgroundHIV infection and opportunistic infections cause oxidative stress (OS), which is associated with tissue damage. Anti-retroviral therapy (ART) is used to treat HIV and decrease the risk of opportunistic infections, but it is unclear whether ART ...
Andama, Alfred +14 more
core +3 more sources
Journal of Lipid Research, 2001 Brefeldin A (BFA) added to primary cultures of rat hepatocytes, at a concentration of 0.2 μg/ml, prevented the assembly of newly synthesized apolipoprotein B (apoB) into mature, secretory VLDL but did not prevent the secretion of apoB as denser particles
Abdel-Malek Hebbachi +1 more
doaj +1 more source
Ursodeoxycholic acid improves bilirubin but not albumin in primary biliary cirrhosis: further evidence for nonefficacy. [PDF]
, 2013 BACKGROUND/AIM: In randomised controlled trials (RCTs) of ursodeoxycholic acid (UDCA), although serum bilirubin is frequently reduced, its effect on disease progression and mortality is unclear.
Burroughs, Andrew K +5 more
core +3 more sources
Gastroenterology, 2019 BACKGROUND & AIMS We investigated the effect of albumin treatment (20% solution) on hypoalbuminemia, cardiocirculatory dysfunction, portal hypertension, and systemic inflammation in patients with decompensated cirrhosis with and without bacterial ...
Javier Fernández +38 more
semanticscholar +1 more source
Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy
IUCrJ, 2020 Dexamethasone, a widely used corticosteroid, has recently been reported as the first drug to increase the survival chances of patients with severe COVID-19.
Ivan G. Shabalin +8 more
doaj +1 more source
Doxorubicin-Loaded Human Serum Albumin Submicron Particles: Preparation, Characterization and In Vitro Cellular Uptake [PDF]
, 2020 Doxorubicin (DOX) is an effective anthracycline antibiotic drug which is commonly used in a broad range cancer therapy. However, due to dose depending side effects and toxicity to non-cancerous tissues, its clinical applications are restricted.
Bäumler, Hans +7 more
core +1 more source
International Journal of General Medicine, 2016 Serum albumin concentration (CP) is a remarkably strong prognostic indicator of morbidity and mortality in both sick and seemingly healthy subjects. Surprisingly, the specifics of the pathophysiology underlying the relationship between CP and ill-health ...
D. Levitt, M. Levitt
semanticscholar +1 more source