Results 91 to 100 of about 6,092 (169)

The evolution of enzyme function in the isomerases. [PDF]

, 2014
The advent of computational approaches to measure functional similarity between enzymes adds a new dimension to existing evolutionary studies based on sequence and structure.
Furnham, Nicholas, Martinez Cuesta, Sergio, Rahman, Syed Asad, Sillitoe, Ian, Thornton, Janet M   +4 more
core   +1 more source

Isolated asthenozoospermia: What should we know? A narrative review of literature

UroPrecision, EarlyView.
ABSTRACT Male infertility contributes to 20%–70% of infertile couple cases worldwide. One of the key challenges in this area is asthenozoospermia or reduced sperm motility. A particular subset, known as isolated asthenozoospermia (iASZ), in which low motility occurs without abnormalities in sperm count or shape, often goes unnoticed and is not well ...
Ahmed Eissa, Khaled Almekaty, Ahmed Zoeir, Hussein Mamdoh, Ayman Mousa, Mohammed Abou‐elenein, Tarek Gameel, Maged Ragab   +7 more
wiley   +1 more source

Efficacy, pharmacokinetic and pharmacodynamic evaluation of Apaziquone in the treatment of non- muscle invasive bladder cancer [PDF]

, 2017
Introduction: Apaziquone (also known as EO9 and Qapzola) is a prodrug that is activated to DNA damaging species by oxidoreductases (particularly NQO1) and has the ability to kill aerobic and/or hypoxic cancer cells.
Comer E, G. J. Peters, G. Reddy, Guancial EA, H. R. Hendriks, J. B. Sweeney, Kal HB, Lamm DL, Panach-Navarrete J, Phillips RM, R. M. Phillips, Walton MI, Workman P   +12 more
core   +2 more sources

Structural analysis of flavinylation in vanillyl-alcohol oxidase [PDF]

, 2000
Vanillyl-alcohol oxidase (VAO) is member of a newly recognized flavoprotein family of structurally related oxidoreductases. The enzyme contains a covalently linked FAD cofactor.
Berkel, Willem J.H. van, Fraaije, MW, Heuvel, Robert H.H. van den, Mattevi, A, van Berkel, WJH, van den Heuvel, RHH   +5 more
core   +1 more source

Genomic context analysis enables the discovery of an unusual NAD‐dependent racemase in phosphonate catabolism

The FEBS Journal, EarlyView.
The authors identify PbfF (previously annotated as a NAD‐dependent dehydrogenase) as a hitherto unknown enzyme in phosphonate catabolism. Guided by genome context analysis, they show that PbfF is actually a racemase, serving to degrade the natural compound (S)‐2‐amino‐1‐hydroxyethylphosphonate (S‐HAEP).
Francesca Ruffolo, Silvia Conciatori, Giovanni Merici, Tamara Dinhof, Jason P. Chin, Claudio Rivetti, Andrea Secchi, Katharina Pallitsch, Alessio Peracchi   +8 more
wiley   +1 more source

Detoxification and stress response genes expressed in a western North American bumble bee, Bombus huntii (Hymenoptera: Apidae) [PDF]

, 2013
BACKGROUND: The Hunt bumble bee (Bombus huntii Greene, Hymenoptera: Apidae) is a holometabolous, social insect important as a pollinator in natural and agricultural ecosystems in western North America.
Dennis L Welker, James P Strange, Junhuan Xu, Rosalind R James   +3 more
core   +1 more source

Hyperuricaemia in type 1 Gaucher disease: is uric acid a biomarker for disease severity?

Internal Medicine Journal, EarlyView.
Abstract Background Elevated serum uric acid (SUA) levels were observed in Gaucher disease type 1 (GD1) patients followed for two decades in northern Israel. There are no previous reports regarding hyperuricaemia in GD1 patients. Aims We aimed to evaluate the frequency of hyperuricaemia in GD1 patients and its correlation to disease severity ...
Zufit Hexner‐Erlichman, Salmas Watad, Jeff Szer, Nayaf Habashi, Hanna Rosenbaum   +4 more
wiley   +1 more source

Enhanced degradation of softwood versus hardwood by the white-rot fungus Pycnoporus coccineus [PDF]

, 2015
16 p.-8 fig.-1 tab. Courier, Marie et al.This study was also funded by the French National Research Agency (A*MIDEX project ANR11-IDEX-0001-02;ANR FUNLOCK ANR-13-BIME-0002-01). The work by the US Department of Energy Joint Genome Institute, a DOE Office
Couturier, Marie, Martínez, Ángel T., Rosso, M. N., Ruiz-Dueñas, F. J.   +3 more
core   +1 more source

OsPRK1/2/3‐mediated reactive oxygen species signaling is required for pollen tube germination in rice

Journal of Integrative Plant Biology, EarlyView.
The rice pollen‐specific receptor‐like kinases OsPRK1, OsPRK2, and OsPRK3 play a crucial role in reactive oxygen species (ROS)‐mediated pollen hydration and germination. Triple mutants display male sterility due to decreased ROS levels and impaired pollen hydration, and their germination phenotype can be partially restored by exogenous application of ...
Eui‐Jung Kim, Ye‐jin Son, Ji‐Hyun Kim, Woo‐Jong Hong, Su Kyoung Lee, Sun Tae Kim, Wanqi Liang, Sunok Moon, Yu‐Jin Kim, Ki‐Hong Jung   +9 more
wiley   +1 more source

The structure of glucose-fructose oxidoreductase from Zymomonas mobilis: an osmoprotective periplasmic enzyme containing non-dissociable NADP [PDF]

, 1996
Background The organism Zymomonas mobilis occurs naturally in sugar-rich environments. To protect the bacterium against osmotic shock, the periplasmic enzyme glucose-fructose oxidoreductase (GFOR) produces the compatible, solute sorbitol by reduction of ...
Baker, Edward N, Kingston, Richard L, Scopes, Robert K   +2 more
core   +1 more source