Results 1 to 10 of about 131,420 (208)
Communications Biology, 2022 PET imaging in human participants revealed that D1 and D2 dopamine receptor availability was associated with eye-blink rates following treatment with oral methylphenidate, but not a placebo.
Şükrü B. Demiral +10 more
doaj +1 more source
Communications Biology, 2022 Joint PET and MRI analyses of cortical D1 and D2 dopamine receptors in healthy adults provide a framework for understanding how dopamine-boosting drugs alter brain function.
Peter Manza +12 more
doaj +1 more source
Neural circuit selective for fast but not slow dopamine increases in drug reward
Nature Communications, 2023 The faster a drug enters the brain, the greater its addictive potential, yet the brain circuits underlying the rate dependency to drug reward remain unresolved.
Peter Manza +14 more
doaj +1 more source
Cholesterol as a modulator of cannabinoid receptor CB2 signaling
Scientific Reports, 2021 Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity ligands of human cannabinoid receptor CB2, we demonstrate that cholesterol increases basal ...
Alexei Yeliseev +7 more
doaj +1 more source
Communications Biology, 2023 Combined PET imaging and mathematical simulations reveal that the rate of dopamine increase in the striatum underlies self-reports of drug “high” in response to oral and intravenous methylphenidate challenges in ...
Dardo Tomasi +15 more
doaj +1 more source
Scientific Reports, 2022 The continuous rise in opioid overdoses in the United States is predominantly driven by very potent synthetic opioids, mostly fentanyl and its derivatives (fentanyls).
Yeona Kang +14 more
doaj +1 more source
4191 The Role of Suggestibility and Trait Anxiety in Young Adult Alcohol Use
Journal of Clinical and Translational Science, 2020 OBJECTIVES/GOALS: The purpose of this study was to investigate how suggestibility and social susceptibility relate to alcohol use in young adult non-dependent alcohol users, and the role of trait anxiety in this relationship. We hypothesized that greater
Alexandra Cowand +6 more
doaj +1 more source
Multidimensional Quality of Life Across the Spectrum of Alcohol Use Behavior
Psychiatric Research and Clinical Practice, 2022 Objective Quality of life (QoL) is inversely associated with alcohol misuse and is a key measure by which recovery from alcohol use disorder (AUD) might be assessed. Yet, the determinants of QoL are scarcely known. The authors examined three ways through
Jeremy W. Luk +6 more
doaj +1 more source
Cell Death Discovery, 2023 The proliferation and differentiation of hepatic progenitor cells (HPCs) drive the homeostatic renewal of the liver under diverse conditions. Liver regeneration is associated with an increase in Axin2+Cnr1+ HPCs, along with a marked increase in the ...
Bani Mukhopadhyay +8 more
doaj +1 more source
Sleep disturbances are associated with cortical and subcortical atrophy in alcohol use disorder
Translational Psychiatry, 2021 Sleep disturbances are prominent in patients with alcohol use disorder (AUD) and predict relapse. So far, the mechanisms underlying sleep disruptions in AUD are poorly understood.
Rui Zhang +11 more
doaj +1 more source