Results 31 to 40 of about 136,710 (292)

Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia

Molecules, 2021
Alcohol consumption is associated with gut dysbiosis, increased intestinal permeability, endotoxemia, and a cascade that leads to persistent systemic inflammation, alcoholic liver disease, and other ailments.
Luis Santos-Molina, Alexa Herrerias, Charles N. Zawatsky, Ozge Gunduz-Cinar, Resat Cinar, Malliga R. Iyer, Casey M. Wood, Yuhong Lin, Bin Gao, George Kunos, Grzegorz Godlewski   +10 more
doaj   +1 more source

Correspondence between cerebral glucose metabolism and BOLD reveals relative power and cost in human brain

Nature Communications, 2019
The brain primarily uses glucose to generate energy, but the relationship of neuronal activity to glucose utilization is not necessarily a simple linear one.
Ehsan Shokri-Kojori, Dardo Tomasi, Babak Alipanahi, Corinde E. Wiers, Gene-Jack Wang, Nora D. Volkow   +5 more
doaj   +1 more source

Multi-omic underpinnings of epigenetic aging and human longevity

Nature Communications, 2023
Biological aging is accompanied by increasing morbidity, mortality, and healthcare costs; however, its molecular mechanisms are poorly understood. Here, we use multi-omic methods to integrate genomic, transcriptomic, and metabolomic data and identify ...
Lucas A. Mavromatis, Daniel B. Rosoff, Andrew S. Bell, Jeesun Jung, Josephin Wagner, Falk W. Lohoff   +5 more
doaj   +1 more source

GPR110 (ADGRF1) mediates anti-inflammatory effects of N-docosahexaenoylethanolamine

Journal of Neuroinflammation, 2019
Background Neuroinflammation is a widely accepted underlying condition for various pathological processes in the brain. In a recent study, synaptamide, an endogenous metabolite derived from docosahexaenoic acid (DHA, 22:6n-3), was identified as a ...
Taeyeop Park, Huazhen Chen, Hee-Yong Kim
doaj   +1 more source

Gut Microbiota‐Derived Anandamide Mediates the Therapeutic Effects of Urolithin A on Alcohol‐Induced Cognitive and Social Dysfunction via CB1R‐DRD2‐RAP1 Signaling Axis

Advanced Science, EarlyView.
This study reveals that Urolithin A (UA) counteracts alcohol‐induced cognitive and social dysfunction (AICSD) via a gut microbiome‐dependent mechanism. UA‐enriched Bacteroids sartorii and Parabacteroids distasonis elevate anandamide (AEA), which activates the CB1R‐DRD2‐Rap1 signaling cascade to drive synaptic repair and reduce neuroinflammation ...
Hongbo Zhang, Zibin Li, Yao Xiao, Ji Bian, Caian He, Chao Liu, Lan Gong, Lin Han, Zhigang Liu, Min Wang   +9 more
wiley   +1 more source

Cannabis Affects Cerebellar Volume and Sleep Differently in Men and Women

Frontiers in Psychiatry, 2021
Background: There are known sex differences in behavioral and clinical outcomes associated with drugs of abuse, including cannabis. However, little is known about how chronic cannabis use and sex interact to affect brain structure, particularly in ...
Katherine L. McPherson, Dardo G. Tomasi, Gene-Jack Wang, Peter Manza, Nora D. Volkow, Nora D. Volkow   +5 more
doaj   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Methylphenidate reorganizes cortical hierarchy through dopaminergic modulation

Nature Communications
Dopaminergic signaling shapes large-scale brain network architecture, constraining neural communication along a principal gradient that spans unimodal sensorimotor to transmodal association cortices.
Dardo Tomasi, Peter Manza, Şükrü Barış Demiral, Weizheng Yan, Kylee B. Miller, Faith Veenker, Joshua Zhao, Christina Lildharrie, Michele-Vera Yonga, Sarah Abey, Michaelene VanDine, Gene-Jack Wang, Nora D. Volkow   +12 more
doaj   +1 more source

Endocannabinoid-dopamine interactions in striatal synaptic plasticity

Frontiers in Pharmacology, 2012
The nigrostriatal dopaminergic system is implicated in action control and learning. A large body of work has focused on the contribution of this system to modulation of the corticostriatal synapse, the predominant synapse type in the striatum ...
Brian Neil Mathur, David M Lovinger
doaj   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source