Results 21 to 30 of about 135 (134)

Kinsenoside‐Loaded Microneedle Accelerates Diabetic Wound Healing by Reprogramming Macrophage Metabolism via Inhibiting IRE1α/XBP1 Signaling Axis

Advanced Science, EarlyView.
Gut metabolite trimethylamine N‐oxide accumulates in the diabetic wound area to amplify macrophage inflammation via enhancing glycolysis activities. Kinsenoside induces macrophage repolarization from M1 to M2 phenotype through inhibiting IRE1α/XBP1 pathway, followed by HIF‐1α‐glycolysis axis repression and mitophagy‐oxidative phosphorylation axis ...
Li Lu, Jiewen Liao, Chao Xu, Yuan Xiong, Juan Zhou, Guangji Wang, Ze Lin, Kangkang Zha, Chuanlu Lin, Ruiyin Zeng, Guandong Dai, Qian Feng, Bobin Mi, Guohui Liu   +13 more
wiley   +1 more source

Engineering von Transmembran‐Alkan‐Monooxygenasen zur Verbesserung des Schlüsselschritts in der Biosynthese des Polymervorläufers Tulipalin A

Angewandte Chemie, EarlyView.
Ein Biosyntheseweg für den Polymervorläufer Tulipalin A ausgehend von Isoprenylacetat wird hier präsentiert. Die Alkan‐Monooxygenase AlkB katalysiert die chemo‐ und regioselektive terminale Hydroxylierung von Isoprenylacetat und die Aktivität konnte durch rationelles Engineering des Membranenzyms weiter gesteigert werden. Die vollständige Oxidation zur
Andrea Nigl, Veronica Delsoglio, Lucija Sovic, Marina Grgić, Lenny Malihan‐Yap, Kamela Myrtollari, Jelena Spasic, Margit Winkler, Gustav Oberdorfer, Andreas Taden, Iva Anić, Robert Kourist   +11 more
wiley   +1 more source

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, EarlyView., 2023
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan‐Yan Wei, Hozumi Motohashi, Takaaki Akaike   +5 more
wiley   +1 more source

Engineering of Transmembrane Alkane Monooxygenases to Improve a Key Reaction Step in the Synthesis of Polymer Precursor Tulipalin A

Angewandte Chemie International Edition, EarlyView.
A biosynthesis route for the polymer precursor tulipalin A starting from isoprenyl acetate is proposed. The alkane monooxygenase AlkB catalyzes the chemoselective terminal hydroxylation of isoprenyl acetate. Rational enzyme engineering further increased the activity of the membrane enzyme.
Andrea Nigl, Veronica Delsoglio, Lucija Sovic, Marina Grgić, Lenny Malihan‐Yap, Kamela Myrtollari, Jelena Spasic, Margit Winkler, Gustav Oberdorfer, Andreas Taden, Iva Anić, Robert Kourist   +11 more
wiley   +1 more source

Thiotemplated Polyketide Chain Fusion and Reductive Cyclization Build the Reactive Butenolide Core of Malleicyprol

Angewandte Chemie International Edition, Accepted Article.
Malleicyprol, a virulence factor of notorious animal and human pathogens of the Burkholderia pseudomallei (BP) group, features a molecular cyclopropanol warhead linked to a reactive butenolide core. Biosynthetic considerations suggested that this heterocycle was formed by the merger of two individual polyketide chains, but the precise mechanism has ...
Jonas Fiedler, Leo Dumjahn, Ishida-Ito Mie, Felix Trottmann, Keishi Ishida, Christian Hertweck   +5 more
wiley   +1 more source

Evaluating the Performance of Ethanol Electrochemical Nanobiosensor Through Machine for Predictive Analysis of Electric Current in Self‐Powered Biosensors

Battery Energy, EarlyView.
Developing electrodes for generating electricity using human body sweating. ABSTRACT In this study, the focus is on ethanol nano biosensors based on alcohol oxidase (AOX) enzymatic reactions and the feasibility of generating electric current for biobatteries.
Afshin Farahbakhsh, Javad Mohebbi Najm Abad, Amin Hekmatmanesh, Heikki Handroos   +3 more
wiley   +1 more source

Evaluation of Polar Substituted Schiff Bases and 1,2,3‐Triazole Hybrids as Anticancer Agents

Chemistry &Biodiversity, EarlyView.
ABSTRACT Polar substituted Schiff bases and 1,2,3‐triazole hybrids (2–6) were successfully synthesized by Schiff base condensation reaction between the previously synthesized triazole 1 and series of polar substituted amines. The chemical structures of the hybrids were confirmed using spectroscopies (NMR and FTIR), CHN elemental analysis and single ...
Yonas Belay, Alfred Muller, Sage Singh, Adedapo S. Adeyinka, Lesetja R. Motadi, Abel K. Oyebamiji   +5 more
wiley   +1 more source

Phytochemical Characterization and Potential Anti‐Oxidative Activity of Lavandula angustifolia subsp. pyrenaica (DC.), Lavandula x intermedia Emeric ex Loisel cv Grosso, and cv Super Essential Oils Compared to a Commercial Lavender Essential Oil

Chemistry &Biodiversity, EarlyView.
ABSTRACT This study investigates the phytochemical profiles and antioxidant properties of three lavender essential oils (LEOs) from Lavandula angustifolia subsp. pyrenaica (DC.), Lavandula x intermedia Emeric ex Loisel cv Grosso, and Lavandula x intermedia Emeric ex Loisel cv Super, and compares them to a commercial one.
Eileen Mac Sweeney, Ylenia Pieracci, Vlad Sebastian Popescu, Gianluca Angius, Guido Flamini, Luisa Pistelli, Giulia Abate, Andrea Mastinu   +7 more
wiley   +1 more source

Designing Enzymatic Reactivity with an Expanded Palette

ChemBioChem, EarlyView.
Innovation in biocatalysis is rapidly increasingly the diversity of catalytic reactivity that can be mediated by enzymes, addressing a key bottleneck for their widespread adoption in industrial chemical synthesis. A key approach to this is building enzymes with unnatural catalytic components that provide an expanded palette with new possibilities for ...
Reuben B. Leveson‐Gower
wiley   +1 more source

Proline Amide Catalyzes Formation of Toxic Crotonaldehyde from Acetaldehyde Under Physiologically Relevant Conditions

ChemBioChem, EarlyView.
Crotonaldehyde‐derived DNA lesions are reported in patients after ethanol exposure, which implies that crotonaldehyde is produced after ethanol ingestion. Here, we show that proline amide, which mimics N‐terminal proline residues on human proteins, can catalyze crotonaldehyde formation from the ethanol metabolite acetaldehyde under physiologically ...
Liam A. Thomas, Vicki L. Emms, Dipti Vashi, Louise Fairall, John W. R. Schwabe, Richard J. Hopkinson   +5 more
wiley   +1 more source