Results 31 to 40 of about 135 (134)

Exploring the Stability and Substrate Profile of Transaminase from Silicibacter pomeroyi with Ancestral Sequence Reconstruction

ChemBioChem, EarlyView.
This study describes the successful identification of ancestral sequences N50 and N49, which have a longer half‐life of approximately four and two times the wild‐type Sp‐amine transaminase, respectively.. This approach effectively enhances the thermal stability of the transaminase.
Luyao Zhao, Bhu‐Bhud Thongrakon, Trishnamoni Gautom, Viktor Sahlberg, Per Berglund   +4 more
wiley   +1 more source

Diversity of ThDP‐Dependent Enzymes Forming Chiral Tertiary Alcohols

ChemBioChem, EarlyView.
Chiral tertiary alcohols are widespread in nature and bioactive compounds; however, their asymmetric synthesis faces several challenges. This review outlines the toolbox of ThDP‐dependent enzymes able to produce tertiary alcohols through the formation of CC bond formation using ketones as acceptor substrates. Herein, the substrate scope, the diversity
Daniela Bjarnesen, Lucrezia Lanza, Francesco Presini, Pier Paolo Giovannini, Michael Müller   +4 more
wiley   +1 more source

Catalysis With Deep Eutectic Solvents: Challenges and Opportunities

ChemCatChem, EarlyView.
Deep eutectic solvents (DESs) are emerging as sustainable alternatives in catalysis, offering tunable properties for diverse chemical transformations. This review explores the dual role of DESs as solvents and catalysts, highlighting advancements in organic chemistry, materials science, CO2 fixation, biomass valorization, polymer degradation, and ...
Eduardo Guzmán
wiley   +1 more source

Strategies towards synthesis and conversion of lignin model compounds

Chemistry – A European Journal, Accepted Article.
The push towards a renewable society where the chemicals being used on a daily basis come from sources which are not going to be depleted within the next few decades is highly sought after. Biomass is one of the most promising opportunities to establish self‐sustainability for the human race.
Christopher William James Murnaghan, Gary N Sheldrake   +1 more
wiley   +1 more source

Intracellular and Extracellular Efficacy of Homoisoflavone Derivatives Against Mycobacterium tuberculosis: Progress Toward Novel Antitubercular Agents

ChemMedChem, Accepted Article.
Tuberculosis (TB) is the leading cause of death among infectious diseases, and new studies focusing new anti‐TB drugs are urgent due to the emergence of drug‐resistant strains. In this regard, homoisoflavones, an underexplored subgroup of flavonoids, were explored for their potential as anti‐TB agents.
Sanderson D. Calixto, Juliane S. Falcão, Stella S. Antunes, Marlon H. Araujo, Alexandre L. B. Cunha, David R. Martins, Sarah M. R. Nascimento, Thatiana L. B. V. Simão, Elena B. Lasunskaia, Nelilma C. Romeiro, Paulo R. R. Costa, Michelle Muzitano, Guilherme S. Caleffi   +12 more
wiley   +1 more source

Changes in Protein Expression of Renal Drug Transporters and Drug‐Metabolizing Enzymes in Autosomal Dominant Polycystic Kidney Disease Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Autosomal dominant polycystic kidney disease is the most prevalent inherited kidney disease and leads to bilateral kidney enlargement and progressive loss of renal function, often over decades. Comorbidities include hypertension, flank pain, and bacterial infections. The condition often necessitates prolonged multidrug therapy.
Annika C. Tillmann, Dorien J. M. Peters, Amin Rostami‐Hodjegan, Patricia Wilson, Jill Norman, Jill Barber, Zubida M. Al‐Majdoub   +6 more
wiley   +1 more source

Transforming a Historical Chemical Synthetic Route for Vanillin Starting from Renewable Eugenol to a Cell‐Free Bi‐Enzymatic Cascade

ChemSusChem, EarlyView.
An artificial enzymatic cascade to access natural vanillin from eugenol/clove oil was developed by revisiting the very first vanillin synthetic process from 19th century. The biosynthetic route consists of just two biocatalysts used as cell‐free preparation and molecular oxygen as oxidizing agent, outperforming also the natural microbial pathway which ...
Elisa Lanfranchi, Valerio Ferrario, Somayyeh Gandomkar, Stefan E. Payer, Erna Zukic, Haris Rudalija, Alexandra Musi, Ines Gaberscek, Yuliya Orel, Doreen Schachtschabel, Christian Willrodt, Michael Breuer, Wolfgang Kroutil   +12 more
wiley   +1 more source

Pharmacokinetics of Ethyl Glucuronide and Ethyl Sulfate and Pharmacodynamic Effects Following Intravenous and Oral Administration of Ethanol to Exercised Horses

Drug Testing and Analysis, EarlyView.
This study describes the pharmacokinetics of ethanol metabolites following intravenous and oral administration to horses. Based on rapid metabolism, ethyl glucuronide is the best candidate for monitoring of illicit administration to performance horses.
Heather K. Knych, Jeff Blea, Mary Scollay, Philip H. Kass, Daniel S. McKemie   +4 more
wiley   +1 more source

Mitochondrial targets in ischaemic heart disease and heart failure, and their potential for a more efficient clinical translation. A scientific statement of the ESC Working Group on Cellular Biology of the Heart and the ESC Working Group on Myocardial Function

European Journal of Heart Failure, EarlyView.
Improving clinical translation of mitoprotective therapies. 31P MRI, phosphorus‐31 magnetic resonance imaging; hiPSC‐CM, human‐induced pluripotent stem cell‐derived cardiomyocyte; IHD, ischaemic heart disease. Abstract Acute myocardial infarction (MI) remains a major cause of death and disability worldwide.
Melanie Paillard, Mahmoud Abdellatif, Ioanna Andreadou, Christian Bär, Luc Bertrand, Bianca J.J.M. Brundel, Gemma Chiva‐Blanch, Sean M. Davidson, Dana Dawson, Fabio Di Lisa, Paul Evans, Zoltan Giricz, Derek J. Hausenloy, Petra Kleinbongard, Frank Lezoualc'h, Elisa Liehn, Christoph Maack, Ange Maguy, Elizabeth Murphy, Cinzia Perrino, Maurizio Pesce, Peter P. Rainer, Katrin Streckfuss‐Bömeke, Matthias Thielmann, Rong Tian, Carlo G. Tocchetti, Jolanda Van Der Velden, Sophie Van Linthout, Serena Zacchigna, Thomas Krieg   +29 more
wiley   +1 more source

Sunlight‐Driven, Catalyst‐Free Synthesis of Cyclobutanes by [2+2] Cycloaddition of Fluorinated Heterochalconoids in Solution

European Journal of Organic Chemistry, Accepted Article.
A cyclobutane ring constitutes an interesting scaffold for the development of new materials and drugs. In this work we describe the [2+2] cycloaddition of chalconoid precursors bearing fluorinated and heterocyclic moieties to produce cyclobutane derivatives in solution.
Concepcion Perez-Melero, Mario De-Juan-Alberdi, Álvaro G. Temprano, Luis Simón   +3 more
wiley   +1 more source