Results 71 to 80 of about 46,498 (194)

Is Deuterium Sequestering by Reactive Carbon Atoms an Important Mechanism to Reduce Deuterium Content in Biological Water?

FASEB BioAdvances, EarlyView.
Deuterium, a heavy isotope of hydrogen, is universal in nature, but it disrupts the mitochondrial ATPase pumps. One mechanism that biological organisms may use to reduce deuterium levels in the mitochondria is to sequester deuterium bound to carbon atoms in a small set of organic molecules that have a unique configuration to support such trapping ...
Stephanie Seneff, Greg Nigh, Anthony M. Kyriakopoulos   +2 more
wiley   +1 more source

Rhodanine-3-acetamide derivatives as aldose and aldehyde reductase inhibitors to treat diabetic complications: synthesis, biological evaluation, molecular docking and simulation studies. [PDF]

BMC Chem, 2021
Bacha MM, Nadeem H, Zaib S, Sarwar S, Imran A, Rahman SU, Ali HS, Arif M, Iqbal J.   +8 more
europepmc   +1 more source

Comparative analysis of two genomic regions among four strains of Buchnera aphidicola, primary endosymbiont of aphids.

, 2004
Preliminary analysis of two selected genomic regions of Buchnera aphidicola BCc, the primary endosymbiont of the cedar aphid Cinara cedri, has revealed a number of interesting features when compared with the corresponding homologous regions of the three ...
Gil, Rosario, Latorre, Amparo, Moya, Andrés, Pérez-Brocal, Vicente   +3 more
core   +1 more source

Downregulation of NAD Kinase Expression in β‐Cells Contributes to the Aging‐Associated Decline in Glucose‐Stimulated Insulin Secretion

Aging Cell, Volume 24, Issue 4, April 2025.
Adequate NADK/NADK2 level is essential to the proper functioning of redox and folate cycles and the purine biosynthesis pathway, and as well as maintenance of GSIS response. During aging, diminished NADK/NADK2 expression alters the metabolic status quo, increasing AICAR production. The latter activates AMPK and suppresses GSIS.
Guan‐Jie Li, Mei‐Ling Cheng, Yu‐Ting Lin, Yu‐Hsuan Ho, Gigin Lin, Chih‐Yung Chiu, Hung‐Yao Ho   +6 more
wiley   +1 more source

Cell cycle specific radiosensitisation by the disulfiram and copper complex [PDF]

, 2017
The disulfiram and copper complex (DSF:Cu) has emerged as a potent radiosensitising anti-cancer agent. The ability of copper to stabilise DSF in a planar conformation and to inhibit DNA replication enzymes stimulated our investigation of the effect of
Anselmi, Giorgio, Bell, Caitlin, Mairs, Robert, Tesson, Mathias   +3 more
core   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

Plasmids in the aphid endosymbiont Buchnera aphidicola with the smallest genomes. A puzzling evolutionary story.

, 2006
Buchnera aphidicola, the primary endosymbiont of aphids, has undergone important genomic and biochemical changes as an adaptation to intracellular life.
Gil, Rosario, Latorre, Amparo, Perez-Brocal, Vicente, Sabater-Muñoz, Beatriz, Silva, Francisco J   +4 more
core   +1 more source

Tryptophan Metabolic Enzyme IL4I1 Inhibits Ferroptosis by Decreasing Ubiquitination of Nrf2 via I3P in Glioblastoma

Cell Proliferation, EarlyView.
Interleukin 4‐induced 1 (IL4I1) is a novel anti‐ferroptosis regulator‐IL4I1 by regulating Nrf2 and serving as a ROS scavenger in glioblastoma multiforme (GBM). In addition, the ubiquitination of Nrf2 could be attenuate by indole‐3‐pyruvic acid binding with Nrf2 directly.
Yang Xu, Yu Hong, Tengfeng Yan, Qian Sun, Fanen Yuan, Shanwen Liang, Liguo Ye, Rongxin Geng, Yangzhi Qi, Qingsong Ye, Qianxue Chen   +10 more
wiley   +1 more source

Identification of Lactaldehyde Reductase and Aldehyde Reductase as Functions of the Same Enzyme Protein in Pig Kidney [PDF]

, 1990
Lactaldehyde reductase activity of pig kidney extract was potently inhibited by aldehyde reductase inhibitors such as barbital and diphenic acid. The lactaldehyde reductase and aldehyde reductase activities from this tissue were co-purified to apparent ...
AKIRA HARA, HIDEAKI MINOURA, HIDEO SAWADA, TAKUSHI KANAZU   +3 more
core   +1 more source

A microbial platform for renewable propane synthesis based on a fermentative butanol pathway [PDF]

, 2015
Background Propane (C3H8) is a volatile hydrocarbon with highly favourable physicochemical properties as a fuel, in addition to existing global markets and infrastructure for storage, distribution and utilization in a wide range of applications ...
Akhtar, MK, Fisher, K, Jones, PR, Kallio, P, Leys, D, Menon, BRK, Menon, N, Pasztor, A, Scrutton, NS   +8 more
core   +2 more sources