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The Effects of Aldosterone on Hypertension-Associated Kidney Injury in a Tg-hAS Mouse Model [PDF]

Biology
Hypertension remains a global health challenge due to its high prevalence and association with premature morbidity and mortality. Aldosterone, a mineralocorticoid hormone, and its receptor, the mineralocorticoid receptor (MR), are highly implicated in ...
Huiying Gu, Zhe Chen, Nicole Du, Sisi Yang, Yongqi Yu, Yansheng Du   +5 more
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Obesity, aldosterone excess, and mineralocorticoid receptor activation: Parallel or intersected circumstances? [PDF]

The Journal of Clinical Hypertension
The obesity pandemic, with its associated comorbidities of hypertension and diabetes, constitutes a global public health issue. Importantly, there is an increasing prevalence of aldosterone excess related to obesity and resultant poor health outcomes ...
Houry Puzantian, Raymond Townsend, Shweta Bansal   +2 more
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Aldosterone is a possible new stimulating factor for promoting vascular calcification

Frontiers in Bioscience-Landmark, 2021
Background: Aldosterone is an important hormone in the renin-angiotensin-aldosterone system (RAAS), and playing a pivotal role in the development of hypertension, heart failure, and other cardiovascular diseases.
Xusheng Zhang, Xiaoou Zhou, Zhanjun Huang, Xiaorong Fan, Xiaoqing Tan, Chengzhi Lu, Jianshe Yang   +6 more
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Comparison of the Chemiluminescence Immunoassay LIAISON® with the Radioimmunoassay for Aldosterone and Renin Measurement

Prague Medical Report, 2021
Determination of renin plasma levels is useful in the diagnosis of hypertension and in the therapeutic follow-up of hypertensive patients. Plasmatic concentration of renin decreases in patients with hypertension due to a primary hyperaldosteronism ...
Jana Uhrová, Hana Benáková, Zdislava Vaníčková, Tomáš Zima   +3 more
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G protein–coupled estrogen receptor: a promising therapeutic target for aldosterone-induced hypertension

Frontiers in Endocrinology, 2023
Aldosterone is one of the most essential hormones synthesized by the adrenal gland because it regulates water and electrolyte balance. G protein–coupled estrogen receptor (GPER) is a newly discovered aldosterone receptor, which is proposed to mediate the
Xuehan Li, Xuehan Li, Xuehan Li, Wenlong Kuang, Wenlong Kuang, Wenlong Kuang, Zhihua Qiu, Zhihua Qiu, Zhihua Qiu, Zihua Zhou, Zihua Zhou, Zihua Zhou   +11 more
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Aldosterone Decreases Vasopressin-Stimulated Water Reabsorption in Rat Inner Medullary Collecting Ducts

Cells, 2020
Aldosterone indirectly regulates water reabsorption in the distal tubule by regulating sodium reabsorption. However, the direct effect of aldosterone on vasopressin-regulated water and urea permeability in the rat inner medullary collecting duct (IMCD ...
Yanhua Wang, Fuying Ma, Eva L. Rodriguez, Janet D. Klein, Jeff M. Sands   +4 more
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Pathology and gene mutations of aldosterone-producing lesions

Endocrine Journal, 2023
The human adrenal cortex secretes aldosterone and cortisol as major corticosteroids. For their production, CYP11B2 and CYP11B1 catalyze the last steps in the syntheses of aldosterone and cortisol, respectively.
Koshiro Nishimoto, Tadashi Ogishima, Yuki Sugiura, Makoto Suematsu, Kuniaki Mukai   +4 more
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Functional Characteristic and Significance of Aldosterone-Producing Cell Clusters in Primary Aldosteronism and Age-Related Hypertension

Frontiers in Endocrinology, 2021
Primary aldosteronism (PA) is one of the most frequent curable forms of secondary hypertension. It can be caused by the overproduction of aldosterone in one or both adrenal glands. The most common subtypes of PA are unilateral aldosterone over-production
Fatin Athirah Pauzi, Elena Aisha Azizan
doaj   +1 more source

Aldosterone induced galectin-3 secretion in vitro and in vivo: from cells to humans. [PDF]

PLoS ONE, 2014
Patients with primary aldosteronism are associated with increased myocardial fibrosis. Galectin-3 is one of the most important mediators between macrophage activation and myocardial fibrosis.To investigate whether aldosterone induces galectin-3 secretion
Yen-Hung Lin, Chia-Hung Chou, Xue-Ming Wu, Yi-Yao Chang, Chi-Sheng Hung, Ying-Hsien Chen, Yu-Lin Tzeng, Vin-Cent Wu, Yi-Lwun Ho, Fon-Jou Hsieh, Kwan-Dun Wu, TAIPAI Study Group   +11 more
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Aldosterone Excess Induced Mitochondria Decrease and Dysfunction via Mineralocorticoid Receptor and Oxidative Stress In Vitro and In Vivo

Biomedicines, 2021
Aldosterone excess plays a major role in the progression of cardiac dysfunction and remodeling in clinical diseases such as primary aldosteronism and heart failure. However, the effect of aldosterone excess on cardiac mitochondria is unclear.
Cheng-Hsuan Tsai, Chien-Ting Pan, Yi-Yao Chang, Shih-Yuan Peng, Po-Chin Lee, Che-Wei Liao, Chia-Tung Shun, Po-Ting Li, Vin-Cent Wu, Chia-Hung Chou, I-Jung Tsai, Chi-Sheng Hung, Yen-Hung Lin   +12 more
doaj   +1 more source