Results 1 to 10 of about 84,187 (148)

SIRT1 Alleviates Aldosterone-Induced Podocyte Injury by Suppressing Mitochondrial Dysfunction and NLRP3 Inflammasome Activation

Kidney Diseases, 2021
Background: Podocyte injury contributes to progressive glomerulosclerosis. Previously, we demonstrated the important role of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in mediating the podocyte injury induced by aldosterone.
Mingzhu Jiang, Min Zhao, Mi Bai, Juan Lei, Yanggang Yuan, Songming Huang, Yue Zhang, Guixia Ding, Zhanjun Jia, Aihua Zhang   +9 more
doaj   +1 more source

Aldosterone Induces Renal Fibrosis and Inflammatory M1-Macrophage Subtype via Mineralocorticoid Receptor in Rats

PLoS ONE, 2016
We aimed to evaluate macrophages heterogeneity and structural, functional and inflammatory alterations in rat kidney by aldosterone + salt administration. The effects of treatment with spironolactone on above parameters were also analyzed.
B. Martín-Fernández, Alfonso Rubio-Navarro, I. Cortegano, S. Ballesteros, Mario Alía, P. Cannata‐Ortiz, Elena Olivares-Álvaro, J. Egido, B. de Andrés, M. Gaspar, N. de Las Heras, V. Lahera, J. Moreno   +12 more
semanticscholar   +1 more source

Both aldosterone and spironolactone can modulate the intracellular ACE/ANG II/AT1 and ACE2/ANG (1‐7)/MAS receptor axes in human mesangial cells

Physiological Reports, 2019
The kidney is an important target of the renin‐ANG‐aldosterone system (RAAS). To date, several studies have demonstrated the existence of a local RAAS in various tissues, including the renal tissue.
Danielle Stoll, Rodrigo Yokota, Danielle Sanches Aragão, Dulce E. Casarini   +3 more
doaj   +1 more source

Higher plasma aldosterone is associated with increased risk of cardiovascular events in hypertensive patients with suspected OSA: UROSAH data

Frontiers in Endocrinology, 2022
ObjectiveTo evaluate the association of plasma aldosterone concentration (PAC) with incident cardiovascular disease (CVD) and all-cause mortality in hypertensive patients with suspected obstructive sleep apnea (OSA) and calculate the optimal cut-off ...
Lin Gan, Nanfang Li, Mulalibieke Heizhati, Mengyue Lin, Qing Zhu, Xiaoguang Yao, Ting Wu, Menghui Wang, Qin Luo, Delian Zhang, Wen Jiang, Junli Hu   +11 more
doaj   +1 more source

Intratumoural aldosterone and CYP11B2 expression levels among different genotypes of aldosterone producing tumours

Endocrine Connections
Primary aldosteronism is the most common endocrine cause of hypertension, affecting 5–10% of hypertensive patients. Determining the source of aldosteronism is necessary for correct diagnosis and further molecular analysis. To investigate the relationship
Tobias Åkerström, Branislav Klimàcek, Matilda Annebäck, Olov Norlén, Peter Stålberg   +4 more
doaj   +1 more source

Clinical diagnostic value of liquid chromatography-tandem mass spectrometry method for primary aldosteronism in patients with hypertension: A systematic review and meta-analysis

Frontiers in Endocrinology, 2022
BackgroundPrimary aldosteronism (PA) is currently considered the most common cause of secondary and endocrine hypertension. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) as a new detection technique has been gradually applied in the diagnosis
Kai-Fang Hua, Kai-Fang Hua, Yan-Hui Wu, Shi-Ting Zhang   +3 more
doaj   +1 more source

Role of ACTH and Other Hormones in the Regulation of Aldosterone Production in Primary Aldosteronism

Frontiers in Endocrinology, 2016
The major physiological regulators of aldosterone production from the adrenal zona glomerulosa are potassium and angiotensin II; other acute regulators include adrenocorticotropic hormone (ACTH) and serotonin.
Nada El Ghorayeb, I. Bourdeau, A. Lacroix   +2 more
semanticscholar   +1 more source

Low‐dose desoxycorticosterone pivalate treatment of hypoadrenocorticism in dogs: A randomized controlled clinical trial

Journal of Veterinary Internal Medicine, 2021
Background Desoxycorticosterone pivalate (DOCP) is a commonly used mineralocorticoid replacement for dogs with primary hypoadrenocorticism (HA), but manufacturer‐recommended dosing protocols can be cost‐prohibitive.
Alysha M. Vincent, Linda K. Okonkowski, Jean M. Brudvig, Kent R. Refsal, Nora Berghoff, N. Bari Olivier, Daniel K. Langlois   +6 more
doaj   +1 more source

Changes of aldosterone levels in patients with type 2 diabetes complicated by moderate to severe obstructive sleep apnea–hypopnea syndrome before and after treatment with continuous positive airway pressure

Journal of International Medical Research, 2019
Objective Both obstructive sleep apnea–hypopnea syndrome (OSAHS) and type 2 diabetes mellitus (T2DM) are closely related to the renin-angiotensin-aldosterone system.
Jie Zhang, Lin Tian, Lixin Guo
doaj   +1 more source

Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration

Redox Biology, 2017
Aldosterone, with pro-oxidation and pro-autophagy capabilities, plays a key role in liver fibrosis. However, the mechanisms underlying aldosterone-promoted liver sinusoidal endothelial cells (LSECs) defenestration remain unknown.
Xiaoying Luo, Dan Wang, Xuan Luo, Xintao Zhu, Guozhen Wang, Zuowei Ning, Yang Li, Xiaoxin Ma, Renqiang Yang, Siyi Jin, Yun Huang, Ying Meng, Xu Li   +12 more
doaj   +1 more source