Results 201 to 210 of about 25,925 (259)

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1685-1695, June 2026.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

The myth of the metabolic baseline: sleep–wake cycles undermine a foundational assumption in organismal biology

Biological Reviews, Volume 101, Issue 3, Page 1491-1510, June 2026.
ABSTRACT Basal and standard metabolic rate (BMR and SMR) are cornerstones of physiological ecology and are assumed to be relatively fixed intrinsic properties of organisms that represent the minimum energy required to sustain life. However, this assumption is conceptually flawed. Many core maintenance processes underlying SMR are temporally partitioned
Helena Norman, Daphne Cortese, Amelia Munson, Jan Lindström, Shaun S. Killen   +4 more
wiley   +1 more source

The Steroidal Profile Modulates Adaptive Immune Response and Prognosis in Adrenocortical Carcinoma: Analysis of TCR and BCR Repertoires

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Adrenocortical carcinoma (ACC) is a rare and aggressive malignant neoplasm with limited therapeutic options and an often poor prognosis. A deeper understanding of its interaction with the immune system is essential for the advancement of personalized treatment strategies, particularly in light of the tumor heterogeneity of hormone production ...
Jean Silva de Souza Resende, Igor Samesima Giner, João Carlos Degraf Muzzi, José Alexandre Marzagão Barbuto, Enzo Lalli, Mauro Antônio Alves Castro, Bonald Cavalcante de Figueiredo   +6 more
wiley   +1 more source

Renal tubular acidosis: A ‘basic’ disorder

Equine Veterinary Education, Volume 38, Issue 7, Page 365-366, July 2026.
H. J. Mason, L. G. Arroyo
wiley   +1 more source

ALDOSTERONE AND ALDOSTERONE ANTAGONISTS.

North Carolina medical journal, 1996
openaire   +1 more source

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Aldosterone, Renin, and Aldosterone-to-Renin Ratio Variability in Screening for Primary Aldosteronism

The Journal of Clinical Endocrinology & Metabolism, 2022
Abstract Context The plasma aldosterone concentration (PAC), renin, and aldosterone-to-renin ratio (ARR) are used to screen for primary aldosteronism (PA). Substantial intra-individual variability of PAC and ARR using plasma renin activity in the context of usual antihypertensive therapy has been ...
Elisabeth Ng, Stella May Gwini, Renata Libianto, Kay Weng Choy, Zhong X Lu, Jimmy Shen, James C G Doery, Peter J Fuller, Jun Yang   +8 more
openaire   +2 more sources

Aldosterone and Aldosteronism

Archives of Internal Medicine, 1977
This book is a logical and welcome successor to the author's previous monograph published in 1959. It combines a broad-brush as well as a detailed analysis of various points and controversies within the aldosterone literature. Two criticisms are offered.
openaire   +1 more source

Regulation of Aldosterone Secretion in Primary Aldosteronism

Hormone and Metabolic Research, 1975
Plasma aldosterone, plasma renin activity and plasma cortisol were determined in patients with primary aldosteronism in response to posture and at short-time intervals overnight while the patient were supine. In the 5 patients with an aldosterone-producing adenoma postural changes in plasma aldosterone were paralleled by those in cortisol while plasma ...
H, Vetter, W, Vetter
openaire   +2 more sources

Aldosterone and aldosterone antagonism in systemic hypertension

Current Hypertension Reports, 2004
Aldosterone mediates both water and electrolyte balance by acting on the renal mineralocorticoid receptors. Recent experimental studies have also documented the presence of these receptors in other body organs, including the brain, blood vessels, and heart, suggesting that aldosterone plays a larger role in normal physiologic function and in ...
William H, Frishman, Charles T, Stier
openaire   +2 more sources

Primary aldosteronism

Journal of Surgical Oncology, 2009
AbstractPrimary aldosteronism is the most common form of secondary hypertension. Case detection is based on an abnormal plasma aldosterone:plasma renin activity ratio and the diagnosis must be confirmed with an aldosterone suppression test. Subtype differentiation should be performed using adrenal venous sampling.
openaire   +4 more sources