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Trends in Cardiovascular Medicine, 2016
In 1955 Dr Jerome Conn first documented primary aldosteronism (PA). Since then, screening, diagnosis and treatment have developed, in the process both refining and complicating management. Currently, screening requires 4-6 weeks of lead-up, including major changes in antihypertensive therapy, followed by a blood draw for plasma aldosterone ...
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In 1955 Dr Jerome Conn first documented primary aldosteronism (PA). Since then, screening, diagnosis and treatment have developed, in the process both refining and complicating management. Currently, screening requires 4-6 weeks of lead-up, including major changes in antihypertensive therapy, followed by a blood draw for plasma aldosterone ...
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The regulation of aldosterone secretion in primary aldosteronism
The American Journal of Medicine, 1972Abstract Twenty patients with primary aldosteronism were studied under various conditions known to influence aldosterone secretion. All patients presented with the classic findings of hypertension, hypokalemia, suppressed plasma renin activity and nonsuppressible aldosterone secretion.
J P, Cain +4 more
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Suppression of Aldosterone by Cyproheptadine in Idiopathic Aldosteronism
New England Journal of Medicine, 1981To study the role of serotonin in regulating the release of aldosterone, we gave single, oral doses of cyproheptadine, an antiserotoninergic agent, to five normal volunteers with high aldosterone levels secondary to sodium deprivation and to 14 patients with aldosteronism (six with idiopathic aldosteronism due to bilateral adrenal hyperplasia and eight
M D, Gross +3 more
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Journal of Endocrinological Investigation, 1995
The basic clinical pathophysiology of primary aldosteronism (PAL) was described by Conn in terms of autonomous production of aldosterone, secondary suppression of renin and development of hypertension with hypokalaemic alkalosis. Conn recognised a normokalaemic form of the syndrome and suggested that it might masquerade as essential hypertension and be
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The basic clinical pathophysiology of primary aldosteronism (PAL) was described by Conn in terms of autonomous production of aldosterone, secondary suppression of renin and development of hypertension with hypokalaemic alkalosis. Conn recognised a normokalaemic form of the syndrome and suggested that it might masquerade as essential hypertension and be
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ALDOSTERONE METABOLITES AND POSSIBLE ALDOSTERONE PRECURSORS IN HYPERTENSION
Journal of Steroid Biochemistry, 1983The value of the urine tests: free aldosterone, aldosterone-18-glucuronide, tetrahydroaldosterone 18-hydroxycorticosterone and 18-hydroxydeoxycorticosterone in distinguishing primary aldosteronism from essential hypertension was studied in patients with typical and atypical primary aldosteronism and in patients with essential hypertension.
P, Vecsei +5 more
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The Journal of Clinical Endocrinology & Metabolism, 1955
I 1934 an amorphous fraction of adrenal extracts was recognized to have a particular^ high life-maintaining activity. Oddly enough, although knowledge of other adrenal hormones accumulated in profusion, it took two decades before a specific crystalline component of this fraction, aldosterone (electrocortin), was isolated and characterized.
R, GAUNT, A A, RENZI, J J, CHART
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I 1934 an amorphous fraction of adrenal extracts was recognized to have a particular^ high life-maintaining activity. Oddly enough, although knowledge of other adrenal hormones accumulated in profusion, it took two decades before a specific crystalline component of this fraction, aldosterone (electrocortin), was isolated and characterized.
R, GAUNT, A A, RENZI, J J, CHART
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The biosynthesis of aldosterone
The Journal of Steroid Biochemistry and Molecular Biology, 1991The cellular mechanisms for aldosterone biosynthesis are incompletely understood. Although the enzymes involved are now well characterized, the dynamics of aldosterone secretion in a variety of rat adrenal preparations are not consistent with the concept that freshly synthesized corticosterone is an important intermediate.
G P, Vinson +4 more
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Canadian Journal of Biochemistry and Physiology, 1955
In 10 experiments, 50–98% of aldosterone added to urine could be recovered in the neutral fraction. Purification of the urinary extracts by various chromatographic procedures resulted in loss of activity. Following an intravenous administration of 600 μgm.
E H, VENNING +3 more
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In 10 experiments, 50–98% of aldosterone added to urine could be recovered in the neutral fraction. Purification of the urinary extracts by various chromatographic procedures resulted in loss of activity. Following an intravenous administration of 600 μgm.
E H, VENNING +3 more
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Primary aldosteronism and aldosterone-associated hypertension
Journal of Clinical Pathology, 2008The field of primary aldosteronism (PA) and aldosterone-related hypertension has undergone rapid evolution. From a relatively rare curiosity PA has become a common problem particularly in selected hypertensive populations. Patients with PA and aldosterone-related hypertension appear to be at higher cardiovascular and renal risk than comparable patients
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ALDOSTERONE AND THE CIRCULATION
Australasian Annals of Medicine, 1962SummaryStudies have been made in Sheffield on volunteers placed on a dietary regime inducing sodium depletion, in order to observe the effect of alteration in the volume of the body fluid compartments on the measured output of aldosterone in the urine. Fluid volumes decreased during sodium depletion. Subsequent treatment with vasopressin injections and
C H, STUART-HARRIS +3 more
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