Results 221 to 230 of about 106,036 (288)
Aims Glucagon‐like peptide‐1 (GLP‐1) and glucagon dual receptor agonists are in clinical development for a range of metabolic conditions, including type 2 diabetes and obesity. The cardiovascular actions at these receptors are well studied, but less is known about their combination.
James Goodman +13 more
wiley +1 more source
Amiloride: revisiting an old drug for resistant hypertension. [PDF]
Lee CJ, Park S.
europepmc +1 more source
Machine learning methods for predicting adverse drug events: A systematic review
Abstract Predicting adverse drug events (ADEs) in outpatient settings is crucial for improving medication safety, identifying high‐risk patients and reducing health‐care costs. While traditional methods struggle with the complexity of health‐care data, machine learning (ML) models offer improved prediction capabilities; however, their effectiveness in ...
Niaz Chalabianloo +8 more
wiley +1 more source
Excess dietary potassium raises blood pressure in male mice by an aldosterone-dependent increase in ENaC. [PDF]
Assmus AM +6 more
europepmc +1 more source
Unexplained Hyponatremia Revealing Vitamin D Deficiency: A Clinical Case Report
ABSTRACT “SIAD” (syndrome of inappropriate antidiuresis) is frequently encountered in clinical practice, often necessitating the exclusion of various differential diagnoses and involving expensive treatments. In cases of SIAD concomitant with vitamin D deficiency, treatment with vitamin D supplementation may not only correct hyponatremia but also ...
Sara Yavuz Ileri
wiley +1 more source
Injectable multi-component hydrogels for the treatment of ascites caused by hepatocellular carcinoma via anti-tumor and reduction of ascites generation. [PDF]
Yang Y +10 more
europepmc +1 more source
Cardiac I/R activates adipose tissue. iatATGL‐KO increases adipocyte size and reduces lipogenesis in WAT, induces whitening and inflammation in BAT, and reduces circulating NEFA and adiponectin levels. As a consequence, cardiac function is reduced, scar formation enhanced, and remote myocardium shows elevated mechanical stress and oxygen consumption ...
Heba Zabri +12 more
wiley +1 more source
Validation of grizzly bear hair hormone profiles as a tool to monitor population demographics
We measured 16 steroid and thyroid hormone concentrations in grizzly bear hair to predict sex, age class, and reproductive status. Models were highly accurate when predicting sex and age class and showed promise for assessing reproductive status. Results illustrate the potential for hair hormone profiles as non‐invasive population monitoring tools ...
Abbey E. Wilson +10 more
wiley +1 more source
Oxidative Stress: Molecular Mechanisms, Diseases, and Therapeutic Targets
Oxidative stress occurs when the reactive oxygen species (ROS) production overwhelms the ROS scavenging, which lead to genomic instability, epigenetic regulation, proteostasis imbalance, and lipid peroxidation, subsequently causing the occurrence and development of numerous diseases. ABSTRACT Although the physiological level of reactive oxygen species (
Yi Qin +10 more
wiley +1 more source

