Aldosterone status associates with insulin resistance in patients with heart failure-data from the ALOFT study [PDF]
, 2009 <b>Background</b>: Aldosterone plays a key role in the pathophysiology of heart failure. In around 50% of such patients, aldosterone 'escapes' from inhibition by drugs that interrupt the renin-angiotensin axis; such patients have a worse ...
Connell, J.M.C. +8 more
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Somatic CACNA1H Mutation As a Cause of Aldosterone-Producing Adenoma
HYPERTENSION, 2020 Supplemental Digital Content is available in the text. Driver somatic mutations for aldosterone excess have been found in ≈90% of aldosterone-producing adenomas (APAs) using an aldosterone synthase (CYP11B2)-guided sequencing approach.
K. Nanba +10 more
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Effect of aldosterone on epithelial-to-mesenchymal transition of human peritoneal mesothelial cells
Kidney Research and Clinical Practice, 2015 Background: Peritoneal fibrosis is one of the major causes of technical failure in patients on peritoneal dialysis. Epithelial-to-mesenchymal transition (EMT) of the peritoneum is an early and reversible mechanism of peritoneal fibrosis. Human peritoneal
Mina Yu +6 more
doaj +1 more source
The Inositol- 1,4,5=Trisphosphate System Is Involved in Rapid Effects of Aldosterone in Human Mononuclear Leukocytes [PDF]
, 1993 There is increasing evidence for rapid steroid action on electrolyte transport in human mononuclear leukocytes (HML). In HML, aldosterone stimulates the Na+/H+ antiporter within a few minutes. Because a variety of hormones and growth factors activate the
Aktas, Janet +4 more
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HYPERTENSION, 2020 Primary aldosteronism is an underdiagnosed cause of hypertension. Although inadequate screening is one reason for underdiagnosis, another important contributor is that clinicians may inappropriately exclude the diagnosis when screening aldosterone ...
Nicholas Yozamp +6 more
semanticscholar +1 more source
Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain [PDF]
, 2013 We demonstrated a role for the Mg2 + transporter TRPM7, a bifunctional protein with channel and α-kinase domains, in aldosterone signaling. Molecular mechanisms underlying this are elusive.
Yogi, A. +10 more
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Relationship between aldosterone and the metabolic syndrome in patients with obstructive sleep apnea hypopnea syndrome: effect of continuous positive airway pressure treatment. [PDF]
PLoS ONE, 2014 BACKGROUND: Metabolic syndrome (MS) occurs frequently in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS). We hypothesized that aldosterone levels are elevated in OSAHS and associated with the presence of MS.
Antonia Barceló +9 more
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Adrenal Venous Sampling for Subtype Diagnosis of Primary Hyperaldosteronism [PDF]
Endocrinology and Metabolism, 2021 Adrenal venous sampling (AVS) is the key procedure for lateralization of primary hyperaldosteronism (PA) before surgery. Identification of the adrenal veins using computed tomography (CT) and intraoperative cortisol assay facilitates the success of ...
Mitsuhide Naruse +11 more
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HYPER‐RESPONSIVENESS OF ALDOSTERONE TO METOCLOPRAMIDE IN ALDOSTERONISM [PDF]
Clinical Endocrinology, 1982 Metoclopramide, a dopamine antagonist, stimulates aldosterone secretion in normal man. We studied the response of plasma aldosterone, plasma renin activity, cortisol, sodium, potassium and serum prolactin to a 10‐mg intravenous dose of metoclopramide in six dexamethasone suppressed patients with aldosteronism (four with adrenal adenoma, two with ...
Gniadek, T. C. +3 more
openaire +4 more sources
The renin‐angiotensin‐aldosterone system and its suppression
Journal of Veterinary Internal Medicine, 2019 Chronic activation of the renin‐angiotensin‐aldosterone system (RAAS) promotes and perpetuates the syndromes of congestive heart failure, systemic hypertension, and chronic kidney disease.
M. Ames, C. Atkins, B. Pitt
semanticscholar +1 more source