Results 61 to 70 of about 96,578 (258)
International Journal of Endocrinology, 2017 Previous in vitro studies demonstrated that aldosterone rapidly activates sodium-hydrogen exchangers 1 and 3 (NHE 1 and 3). In vitro investigations revealed that protein kinase C (PKC) regulates NHE properties. We previously demonstrated that aldosterone
Somchit Eiam-Ong +3 more
doaj +1 more source
ESC Heart Failure, EarlyView.Abstract Aims Renin–angiotensin–aldosterone system inhibitors (RAASi) are foundational in the management of heart failure (HF) and chronic kidney disease (CKD) but increase the risk of hyperkalaemia. To facilitate continuation of RAASi therapy, guidelines suggest managing hyperkalaemia using newer potassium binders such as sodium zirconium ...
Charles V. Pollack Jr. +9 more
wiley +1 more source
ESC Heart Failure, EarlyView.Abstract Aims The last released European guidelines on the management of heart failure (HF) recommend in patients with chronic HF with reduced ejection fraction (HFrEF) a pharmacological approach based on four fundamental drugs to be rapidly implemented and then uptitrated to modify disease progression.
Stefania Paolillo +62 more
wiley +1 more source
Electronic Health Record Phenotyping with Internally Assessable Performance (PhIAP) using Anchor-Positive and Unlabeled Patients [PDF]
arXiv, 2019 Building phenotype models using electronic health record (EHR) data conventionally requires manually labeled cases and controls. Assigning labels is labor intensive and, for some phenotypes, identifying gold-standard controls is prohibitive. To facilitate comprehensive clinical decision support and research, we sought to develop an accurate EHR ...
arxiv
ESC Heart Failure, EarlyView.Graphical representation of main findings and article highlights. Abstract Aims Understanding heart failure (HF) characteristics is essential to improve patient outcomes. Categorizing HF beyond left ventricular ejection fraction (LVEF) is challenging due to heterogeneous clinical presentation and aetiologies.
Rubén Fuentes Artiles +4 more
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundDuring high sodium intake, the renin‐angiotensin‐aldosterone system is downregulated and nitric oxide signaling is upregulated in order to remain in sodium balance.
Kelly A. Hyndman +7 more
doaj +1 more source
Steroid Receptors and Vertebrate Evolution [PDF]
arXiv, 2019 Considering that life on earth evolved about 3.7 billion years ago, vertebrates are young, appearing in the fossil record during the Cambrian explosion about 542 to 515 million years ago. Results from sequence analyses of genomes from bacteria, yeast, plants, invertebrates and vertebrates indicate that receptors for adrenal steroids (aldosterone ...
arxiv
ESC Heart Failure, EarlyView.Abstract Background Chronic kidney disease (CKD) has a high prevalence in patients with heart failure (HF) and is associated with prolonged hospitalization, increased need for intensive care and mortality. There is an urgent need to identify factors that influence the interaction between heart and kidney disorders, often described as cardiorenal ...
Alexander Reinecke +7 more
wiley +1 more source
Journal of Pharmacological Sciences, 2008 There is increasing evidence indicating the roles of aldosterone and mineralocorticoid receptor (MR) in the pathogenesis of renal injury. In rats, chronic treatment with aldosterone and salt results in severe proteinuria and renal tissue injury ...
Hideyasu Kiyomoto +3 more
doaj