Results 81 to 90 of about 4,200 (201)

Effects of aliskiren on myocardial matrix gene expression.

, 2013
Real time PCR was performed with ventricular tissue obtained from mice after 12-inducing diet and different doses of aliskiren. Figure 3A demonstrates changes in expression of COL1A1(alpha 1 chain of type I collagen) and 3B shows changes in COL1A2(alpha2
Jian Guan (288307), Gaurav Alreja (495784), Nicole Metes-Kosik (495785), Jacob Joseph (495786), Hui Zhi (106532), Ivan Luptak (495783), Jianru Shi (288305)   +6 more
core   +1 more source

Combined renin inhibition/(pro)renin receptor blockade in diabetic retinopathy--a study in transgenic (mREN2)27 rats.

PLoS ONE, 2014
Dysfunction of renin-angiotensin system (RAS) contributes to the pathogenesis of diabetic retinopathy (DR). Prorenin, the precursor of renin is highly elevated in ocular fluid of diabetic patients with proliferative retinopathy.
Wendy W Batenburg, Amrisha Verma, Yunyang Wang, Ping Zhu, Mieke van den Heuvel, Richard van Veghel, A H Jan Danser, Qiuhong Li   +7 more
doaj   +1 more source

Antihypertensive efficacy and tolerability of aliskiren/amlodipine single- pill combinations in patients with an inadequate response to aliskiren monotherapy.

, 2012
Many patients with hypertension will require multiple antihypertensive drugs to achieve blood pressure (BP) control. This double-blind study evaluated the efficacy and safety of aliskiren/amlodipine single-pill combinations (SPCs) in patients with mild ...
Thomas M, Troffa C, GLORIOSO, Nicola Filippo, Patel S, Baek I, Argiolas G, Zhang J.   +6 more
core  

Aliskiren-binding increases the half life of renin and prorenin in rat aortic vascular smooth muscle cells

, 2008
Renin inhibition with aliskiren has been reported to cause a greater rise in renin than other types of renin-angiotensin system blockade, thereby potentially leading to angiotensin generation or stimulation of the human (pro)renin receptor (h(P)RR). Here
Müller, D. (Dominik), Nguyen, G., Danser, A.H., Batenburg, Wendy, Muller, DN, Oosterbeek, Jeanette, Nguyen, G, Bader, M. (Michael), Batenburg, W.W., Mueller, D.N., Bruin, R.J.A. (René) de, Danser, A.H.J. (Jan), van Gool, J.M., Danser, Jan, Gool, J.M. (Jeanette) van, Bruin, Rene, Bader, M, Nguyen, G. (Genevieve), Bader, M., de Bruin, R.J., Batenburg, W.W. (Wendy)   +20 more
core   +1 more source

Add-On Aliskiren Elicits Stronger Renoprotection Than High-Dose Valsartan in Type 2 Diabetic KKAy Mice That Do Not Respond to Low-Dose Valsartan

Journal of Pharmacological Sciences, 2012
We hypothesized that aliskiren provides renoprotection in diabetic animals that did not receive sufficient renoprotection by AT1-receptor antagonist treatment.
Bai Lei, Daisuke Nakano, Yu-Yan Fan, Kento Kitada, Hirofumi Hitomi, Hiroyuki Kobori, Hirohito Mori, Tsutomu Masaki, Akira Nishiyama   +8 more
doaj   +1 more source

Aliskiren-Loaded Nanoparticles Downregulate (Pro)renin Receptor and ACE Gene Expression in the Heart of Spontaneously Hypertensive Rats: Effect on NADPH Oxidase. [PDF]

Int J Mol Sci
We aimed to determine effects of aliskiren, a direct renin inhibitor, loaded onto polymeric nanoparticles on the (pro)renin receptor (Atp6ap2), angiotensin II type 1 receptor (Agtr1), and angiotensin-converting enzyme (ACE) gene expression in the heart ...
Barta A, Cebova M, Kovac A, Koneracka M, Zavisova V, Pechanova O.   +5 more
europepmc   +2 more sources

Aliskiren-mode of action and preclinical data

, 2008
Hypertension is one of the major health care problems worldwide since it markedly increases the risk for development of heart disease, stroke, generalized vascular disease, and renal failure.
Derer, W., Mueller, D.N., Dechend, R.
core   +1 more source

Combination of Chymostatin and Aliskiren attenuates ER stress induced by lipid overload in kidney tubular cells

Lipids in Health and Disease, 2018
Background Lipotoxicity plays an important role in the pathogenesis of kidney injury. Our previous study demonstrated that activation of local renin-angiotensin system (RAS) was involved in saturated free fatty acids palmitic acid (PA)-induced tubular ...
Miaojuan Qiu, Suchun Li, Lizi Jin, Pinning Feng, Yonglun Kong, Xiaoduo Zhao, Yu Lin, Yunyun Xu, Chunling Li, Weidong Wang   +9 more
doaj   +1 more source

Urinary cytokine profiles according to the site of blockade of the renin-angiotensin system in nephrectomized rats

Brazilian Journal of Nephrology
Introduction: It is still unknown how the pharmacological inhibition of the Renin Angiotensin System (RAS) impacts the levels of inflammation and fibrosis biomarkers.
Nilo César do Vale Baracho, Kátia Daniela da Silveira, Natália Pessoa Rocha, Thiago Macedo Cordeiro, Victor Feracin, Regina Maria Pereira, Marconi Augusto Aguiar dos Reis, Mauro Martins Teixeira, Ana Cristina Simões e Silva   +8 more
doaj   +1 more source

Acute Effect of Aliskiren on Smoking-Induced Endothelial Dysfunction in Smoker

, 2014
Background: We aimed to examine the acute effect of aliskiren on smoking-induced endothelial dysfunction in smoker.Methods: Nineteen male smokers were enrolled.
HA Uchida, Hatsuzo Uchida, Jun Wada, Haruhito Adam Uchida   +3 more
core   +1 more source