Results 61 to 70 of about 2,710 (165)

Add-On Aliskiren Elicits Stronger Renoprotection Than High-Dose Valsartan in Type 2 Diabetic KKAy Mice That Do Not Respond to Low-Dose Valsartan

Journal of Pharmacological Sciences, 2012
We hypothesized that aliskiren provides renoprotection in diabetic animals that did not receive sufficient renoprotection by AT1-receptor antagonist treatment.
Bai Lei, Daisuke Nakano, Yu-Yan Fan, Kento Kitada, Hirofumi Hitomi, Hiroyuki Kobori, Hirohito Mori, Tsutomu Masaki, Akira Nishiyama   +8 more
doaj   +1 more source

Asian Pacific Society of Nephrology Clinical Practice Guideline on Diabetic Kidney Disease—2025 Update

Nephrology, Volume 30, Issue S2, Page 3-56, July 2025.
Adrian Liew, Sunita Bavanandan, Chuan‐Ming Hao, Soo Kun Lim, Narayan Prasad, Manisha Sahay, Paweena Susantitaphong, Veena Roberts, Eranga Wijewickrama, Muh Geot Wong, Sydney C. W. Tang   +10 more
wiley   +1 more source

Combination of Chymostatin and Aliskiren attenuates ER stress induced by lipid overload in kidney tubular cells

Lipids in Health and Disease, 2018
Background Lipotoxicity plays an important role in the pathogenesis of kidney injury. Our previous study demonstrated that activation of local renin-angiotensin system (RAS) was involved in saturated free fatty acids palmitic acid (PA)-induced tubular ...
Miaojuan Qiu, Suchun Li, Lizi Jin, Pinning Feng, Yonglun Kong, Xiaoduo Zhao, Yu Lin, Yunyun Xu, Chunling Li, Weidong Wang   +9 more
doaj   +1 more source

Urinary cytokine profiles according to the site of blockade of the renin-angiotensin system in nephrectomized rats

Brazilian Journal of Nephrology
Introduction: It is still unknown how the pharmacological inhibition of the Renin Angiotensin System (RAS) impacts the levels of inflammation and fibrosis biomarkers.
Nilo César do Vale Baracho, Kátia Daniela da Silveira, Natália Pessoa Rocha, Thiago Macedo Cordeiro, Victor Feracin, Regina Maria Pereira, Marconi Augusto Aguiar dos Reis, Mauro Martins Teixeira, Ana Cristina Simões e Silva   +8 more
doaj   +1 more source

Identifying treatment response to antihypertensives in patients with obesity-related hypertension

Clinical Hypertension, 2017
Background In patients with obesity-related hypertension (ORH), reaction to antihypertensive medication is likely influenced by patientcharacteristics.
Ilse M. Schrover, Jannick A. N. Dorresteijn, Jodine E. Smits, A. H. Jan Danser, Frank L. J. Visseren, Wilko Spiering   +5 more
doaj   +1 more source

Direct renin inhibitor aliskiren in women with menopausal metabolic syndrome and arterial hypertension

Кардиоваскулярная терапия и профилактика, 2011
Aim. To study the effectiveness of a direct renin inhibitor, aliskiren, in patients with menopausal metabolic syndrome (MMS), and to assess aliskiren effects on blood pressure (BP), carbohydrate and lipid metabolism parameters, microalbuminuria, and ...
Yu. V. Zhernakova, V. B. Mychka, Yu. A. Ponomarev, S. N. Tolstov, E. V. Tishina, K. P. Ivanov, I. E. Chazova   +6 more
doaj   +1 more source

Renin-angiotensin-aldosterone system in the elderly: rational use of aliskiren in managing hypertension

Clinical Interventions in Aging, 2009
Karl AndersenDepartment of Medicine, Division of Cardiology, Landspitali University Hospital, University of Iceland, Reykjavik, IcelandAbstract: The overall purpose of hypertension treatment is 2-fold. First, patients often have symptoms that are related
Karl Andersen
doaj  

Clinical application of direct renin inhibitor aliskiren in combined therapy of patients with arterial hypertension and metabolic syndrome

RUDN Journal of Medicine, 2010
The article presents the results of clinical application of direct renin inhibitor aliskiren in combination therapy in patients with arterial hypertension and obesity.
O V Dralova, M L Maximov, A S Ermolaeva
doaj  

The Anti-Inflammatory Effect of Different Doses of Aliskiren in Rat Models of Inflammation

Drug Design, Development and Therapy, 2020
Tavga Ahmed Aziz, Ahmed Azad Kareem, Hemn Hassan Othman, Zheen Aorahman Ahmed Department of Pharmacology and Toxicology, College of Pharmacy, University of Sulaimani, Sulaimani, Kurdistan Region, IraqCorrespondence: Tavga Ahmed AzizDepartment of ...
Aziz TA, Kareem AA, Othman HH, Ahmed ZA
doaj  

Aliskiren –An overview

Bangladesh Journal of Medicine, 2015
The renin-angiotensin system (RAS) or the renin-angiotensin-aldosterone system (RAAS) is a major endocrine/ paracrine system that regulates blood pressure (BP) via angiotensin release as well as fluid and electrolyte homeostasis via aldosterone release.
openaire   +2 more sources