Results 61 to 70 of about 4,200 (201)
Aliskiren prevents reactive myocardial fibrosis induced by hyperhomocysteinemia.
, 2013 Upper panel shows representative sections from various groups demonstrating that interstitial fibrosis (panels A, B, C and G) and perivascular fibrosis (Panels D, E, F and H) are decreased by low and high dose aliskiren.
Jian Guan (288307) +6 more
core +1 more source
Aliskiren, ALTITUDE, and the Implications for ATMOSPHERE [PDF]
European Journal of Heart Failure, 2012 Blockade of the renin–angiotensin system (RAS) is a core therapeutic strategy in systolic heart failure.1 The value of angiotensin-converting enzyme (ACE) inhibitors was proven in two pivotal trials conducted >20 years ago. More recently, angiotensin receptor blockers (ARBs) have also been shown to be beneficial in systolic heart failure both as an ...
McMurray, John J V +5 more
openaire +3 more sources
The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Transporters
British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +28 more
wiley +1 more source
Contrasting effects of aliskiren versus losartan on hypertensive vascular remodeling [PDF]
, 2013 Background: Hyperactivation of the renin-angiotensin system contributes to hypertension-induced upregulation of vascular matrix metalloproteinases (MMPs) and remodeling, especially in the two kidney, one clip (2K1C) hypertension model.
Guimaraes, Danielle +11 more
core +1 more source
British Journal of Clinical Pharmacology, Volume 91, Issue 11, Page 3031-3041, November 2025.Aims “Triple whammy” (TW) refers to the concomitant use of diuretics, renin‐angiotensin‐aldosterone system inhibitors (RAASI) and non‐steroidal anti‐inflammatory drugs (NSAIDs). The aim of this article is to analyse the association between TW exposure and acute kidney injury (AKI), among other morbi‐mortality outcomes.
Dulce María Calvo +4 more
wiley +1 more source
Pharmacokinetic, pharmacodynamic and clinical evaluation of aliskiren for hypertension treatment
, 2010 reas covered in this review: The present review summarizes the pharmacokinetic and pharmacodynamic properties of aliskiren along with the clinical trials that took into account the effects of aliskiren on blood pressure control and on a number of renal ...
Angeli F +11 more
core +1 more source
European Journal of Heart Failure, Volume 27, Issue 11, Page 2198-2210, November 2025.Heart failure (HF) and atrial fibrillation (AF) are major global health challenges with rising prevalence and significant morbidity, mortality, and healthcare burden. Despite advances in HF management, AF remains a critical comorbidity that worsens outcomes and requires ad hoc treatment strategies, increasing the risk of non‐adherence and side effects.
Mark Luedde +24 more
wiley +1 more source
Aliskiren and valsartan combination therapy for the management of hypertension
, 2010 Benjamin J EpsteinDepartments of Pharmacotherapy and Translational Research and Medicine, Colleges of Pharmacy and Medicine, University of Florida, Gainesville, Florida, USA and East Coast Institute for Research, Jacksonville, Florida, USAAbstract ...
Benjamin J Epstein
core
Journal of Taibah University for Science, 2017 A simple, selective and precise method based on HPTLC has been developed for the simultaneous determination of aliskiren and hydrochlorothiazide in a fixed-dose tablet formulation and human plasma.
Jui J. Pandya +5 more
doaj +1 more source