The Anticancer Effect of Natural Plant Alkaloid Isoquinolines
International Journal of Molecular Sciences, 2021 Isoquinoline alkaloids-enriched herbal plants have been used as traditional folk medicine for their anti-inflammatory, antimicrobial, and analgesic effects. They induce cell cycle arrest, apoptosis, and autophagy, leading to cell death.
Dahye Yun, S. Yoon, S. Park, Y. Park
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Discovery and engineering of colchicine alkaloid biosynthesis
Nature, 2020 Few complete pathways have been established for the biosynthesis of medicinal compounds from plants. Accordingly, many plant-derived therapeutics are isolated directly from medicinal plants or plant cell culture1.
Ryan S. Nett +2 more
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The scaffold-forming steps of plant alkaloid biosynthesis.
Natural product reports (Print), 2020 Alkaloids from plants are characterised by structural diversity and bioactivity, and maintain a privileged position in both modern and traditional medicines. In recent years, there have been significant advances in elucidating the biosynthetic origins of
Benjamin R. Lichman
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Gene clustering and copy number variation in alkaloid metabolic pathways of opium poppy
Nature Communications, 2020 Genes in plant secondary metabolic pathways enable biosynthesis of a range of medically and industrially important compounds, and are often clustered on chromosomes.
Qiushi Li +10 more
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Advantages of trend analysis in stability studies for prediction of potential OOS result within estimated shelflife of medicinal product [PDF]
Makedonsko Farmacevtski BiltenStability studies are crucial for pharmaceutical product registration, providing vital data to assess batch-to-batch consistency, monitor critical quality attributes, and ensure the product's quality, safety, and efficacy over its entire shelf life ...
Milena Nanov +4 more
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Structure-activity relationships of synthetic analogs of jasmonic acid and coronatine on induction of benzo[c]phenanthridine alkaloid accumulation in Eschscholzia californica cell cultures [PDF]
, 2000 A facile test system based on the accumulation of benzo[c]phenanthridine alkaloids in Eschscholzia californica cell suspension culture (an indicator of defense gene activation) has been used to analyze a series of synthetic compounds for elicitor-like ...
Dzink J.L. +5 more
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Molecules, 2019 Annona species have been a valuable source of anti-infective and anticancer agents. However, only limited evaluations of their alkaloids have been carried out. This review collates and evaluates the biological data from extracts and purified isolates for
A. S. Nugraha +3 more
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Analysis of alkaloids (indole alkaloids, isoquinoline alkaloids, tropane alkaloids)
, 2020 Alkaloids are a large cluster of molecules found in Mother Nature all over the world. They are all secondary compounds and collection of miscellaneous elements and biomolecules, derived from amino acids or from transamination. This diverse chemical group is categorized, based on the amino acids that deliver their nitrogen atom and part of their ...
Dey, Prasanta +7 more
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Optimization of a forced degradation study of atorvastatin employing an experimental design approach
Macedonian Journal of Chemistry and Chemical Engineering, 2018 This study involved the optimization of experimental conditions for the forced degradation of atorvastatin employing the experimental design (DoE) approach, as a scientific multifactorial strategy.
Maja Hadzieva Gigovska +7 more
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Application of recombinant DNA technology to studies on plant secondary metabolism [PDF]
, 2001 This review which is concerned with the application of recombinant DNA technology to studies on plant secondary metabolism, presents the more common plant transformation strategies and shows how these genetic approaches are being used in attempts to ...
Yeoman, Michael M., Zárate, Rafael
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