Journal of Analytical Methods in Chemistry, 2019 The purpose of this study was to develop and validate a discriminative dissolution method for the metformin film-coated tablet with immediate release of the active substance that belongs to class III of the Biopharmaceutical Classification System (BCS ...
Ivana Mitrevska +5 more
doaj +1 more source
Review on Chemical Constituents and Biological Activity of Piper betle L.
Shipin gongye ke-ji, 2022 As a “medicine food homology” plant, the Piper betle L. has the characteristics of spicy, slightly sweet, and warm in nature, which can be used for treating cold, cough, stomachache, and eczema.
Tailing JIANG +9 more
doaj +1 more source
ANet: Autoencoder-Based Local Field Potential Feature Extractor for Evaluating An Antidepressant Effect in Mice after Administering Kratom Leaf Extracts [PDF]
arXiv, 2022 Kratom (KT) typically exerts antidepressant (AD) effects. However, evaluating which form of KT extracts possesses AD properties similar to the standard AD fluoxetine (flu) remained challenging. Here, we adopted an autoencoder (AE)-based anomaly detector called ANet to measure the similarity of mice's local field potential (LFP) features that responded ...
arxiv
Marine Alkaloid 2,2-Bis(6-bromo-3-indolyl) Ethylamine and Its Synthetic Derivatives Inhibit Microbial Biofilms Formation and Disaggregate Developed Biofilms [PDF]
, 2019 The antimicrobial activity of the marine bisindole alkaloid 2,2-bis(6-bromo-3-indolyl) ethylamine (1) and related synthetic analogues (compounds 2–8) against target microorganisms was investigated by Minimum Inhibitory Concentration (MIC) determination ...
Baffone, Wally +3 more
core +1 more source
International Journal of Analytical Chemistry, 2018 This manuscript describes comprehensive approach for assessment of degradation behavior of simvastatin employing experimental design methodology as scientific multifactorial strategy.
Maja Hadzieva Gigovska +6 more
doaj +1 more source
Poison Frog Colors Are Honest Signals Of Toxicity, Particularly For Bird Predators [PDF]
, 2012 Antipredator defenses and warning signals typically evolve in concert. However, the extensive variation across taxa in both these components of predator deterrence and the relationship between them are poorly understood.
Cummings, Molly E., Maan, Martine E.
core +3 more sources
Angewandte Chemie, EarlyView.A single‐step biocatalytic route to complex indolizidine and quinolizidine alkaloids is described that relies on transaminase‐triggered double intramolecular aza‐Michael methodology. In one case, a retro‐double intramolecular aza‐Michael reaction enables dynamic kinetic resolution. Abstract Biocatalysis is now a well‐established branch of catalysis and
Adam O'Connell +10 more
wiley +2 more sources
Optimized genotyping method for identification of bacterial contaminants in pharmaceutical industry
Acta Pharmaceutica, 2016 Microbiological control is of crucial importance in the pharmaceutical industry regarding the possible bacterial contamination of the environment, water, raw materials and finished products. Molecular identification of bacterial contaminants based on DNA
Stamatoski Borche +4 more
doaj +1 more source
Recent Discovery of Heterocyclic Alkaloids from Marine-Derived Aspergillus Species
Marine Drugs, 2020 Nitrogen heterocycles have drawn considerable attention due to of their significant biological activities. The marine fungi residing in extreme environments are among the richest sources of these basic nitrogen-containing secondary metabolites. As one of
Kuo Xu +3 more
doaj +1 more source
Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice [PDF]
, 2018 Preparations of the root bark of Tabernanthe iboga have long been used in Central and West African traditional medicine to combat fatigue, as a neuro-stimulant in rituals, and for treatment of diabetes. The principal alkaloid of T.
Akinyeke, Tunde +11 more
core +1 more source