Results 31 to 40 of about 287,843 (358)

Comprehensive Assessment of Degradation Behavior of Simvastatin by UHPLC/MS Method, Employing Experimental Design Methodology

International Journal of Analytical Chemistry, 2018
This manuscript describes comprehensive approach for assessment of degradation behavior of simvastatin employing experimental design methodology as scientific multifactorial strategy.
Maja Hadzieva Gigovska, Ana Petkovska, Jelena Acevska, Natalija Nakov, Packa Antovska, Sonja Ugarkovic, Aneta Dimitrovska   +6 more
doaj   +1 more source

Influence of Postharvest Drying Temperatures on Alkaloid Levels in Goldenseal (Hydrastis canadensis L.)

HortScience, 2021
Goldenseal (Hydrastis canadensis L.) is a medicinal forest herb native to Appalachia. Its roots and rhizomes are used as an antimicrobial and for the treatment of intestinal ailments.
Grady H. Zuiderveen, Eric P. Burkhart, Joshua D. Lambert   +2 more
doaj   +1 more source

Total Synthesis and Structural Revision of the Alkaloid Incargranine B [PDF]

, 2013
Seeing double: Consideration of the biosynthetic origins of incargranineB, which was originally assigned an unprecedented indolo[1.7]naphthyridine structure, led to the proposal of a dipyrroloquinoline framework as a more biosynthetically feasible ...
Bates, Brown, Drew, Green, Hase, Nicolaou, Shen, Su, Zimmermann   +8 more
core   +1 more source

Development and Validation of Discriminative Dissolution Method for Metformin Immediate-Release Film-Coated Tablets

Journal of Analytical Methods in Chemistry, 2019
The purpose of this study was to develop and validate a discriminative dissolution method for the metformin film-coated tablet with immediate release of the active substance that belongs to class III of the Biopharmaceutical Classification System (BCS ...
Ivana Mitrevska, Tina Achkoska, Katerina Brezovska, Krume Toshev, Aneta Dimitrovska, Sonja Ugarkovic   +5 more
doaj   +1 more source

Alternative final steps in berberine biosynthesis in Coptis japonica cell cultures [PDF]

, 1988
In Coptis japonica cell cultures an alternative pathway has been discovered which leads from (S)-tetrahydrocolumbamine via (S)-canadine to berberine. The two enzymes involved have been partially purified.
Galneder, E., Rüffer, Martina, Tabata, M., Wanner, G., Zenk, Meinhart H.   +4 more
core   +1 more source

Berberine–cinnamic acid co‐crystal effect in ameliorating hyperlipidemia might be regulated through the PI3K/AKT/mTOR/SREBP‐1 signaling pathway

FEBS Open Bio, EarlyView.
Berberine–cinnamic acid co‐crystal (BBR‐CA) inhibits the phosphorylation of the phosphatidylinositol 3‐kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway, suppressing the transfer of pre‐sterol regulatory element‐binding proteins‐1 (SREBP‐1) from the endoplasmic reticulum to the nucleus. This results in a decrease in the expression level of
Wenheng Gao, Yunlong Li, Lihua Chen, Wenshuo Yang, Yong He, Ye Yang, Dengke Yin, Song Tan   +7 more
wiley   +1 more source

Optimized genotyping method for identification of bacterial contaminants in pharmaceutical industry

Acta Pharmaceutica, 2016
Microbiological control is of crucial importance in the pharmaceutical industry regarding the possible bacterial contamination of the environment, water, raw materials and finished products. Molecular identification of bacterial contaminants based on DNA
Stamatoski Borche, Ilievska Miroslava, Babunovska Hristina, Sekulovski Nikola, Panov Sasho   +4 more
doaj   +1 more source

Development of chromatographic methods for thebaine detection and quantification along with some of related alkaloid derivatives

Macedonian Journal of Chemistry and Chemical Engineering, 2015
Thebaine is naturally occurring alkaloid  which is of great importance in the pharmaceutical industry and  up to now there is not a Pharmacopoeial monograph for this compound.
Marija Spasevska, Jane B Bogdanov, Hristina Babunovska   +2 more
doaj   +1 more source

Report from the 5th international symposium on mycotoxins and toxigenic moulds : challenges and perspectives (MYTOX) held in Ghent, Belgium, May 2016 [PDF]

, 2016
The association research platform MYTOX “Mycotoxins and Toxigenic Moulds” held the 5th meeting of its International Symposium in Ghent, Belgium on 11 May 2016.[...
Audenaert, Kris, Croubels, Siska, De Saeger, Sarah   +2 more
core   +2 more sources

Research progress on the metabolic transformation of Shenling Baizhu San under the influence of the gut microbiota

Advanced Chinese Medicine, EarlyView.
Abstract The gut microbiota plays a pivotal role in maintaining host metabolic homeostasis and overall physiological functions. Shenling Baizhu San (SLBZS), a time‐honored classical prescription for tonifying Qi, strengthening the spleen, removing dampness, and arresting diarrhea, has shown broad clinical efficacy in digestive disorders.
Jinlan Di, Xiaochun Zhang
wiley   +1 more source