Results 151 to 160 of about 103,487 (263)

Multifaceted modulation of human opioid receptors by kratom alkaloids: binding affinity, functional selectivity, and allosteric activity. [PDF]

Front Pharmacol
Hemby SE, Rangel-Grimaldo M, McIntosh S, Zheng J, Flores-Bocanegra L, Graf TN, Coover RA, Oberlies NH.   +7 more
europepmc   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Monitoring and Managing of Ergot Alkaloids in Cereal Grains: A Comprehensive Analysis of Analytical Challenges, Sampling Uncertainty, and Processing for Food Safety. [PDF]

Compr Rev Food Sci Food Saf
Kodikara C, Bandara N, Tittlemier SA.
europepmc   +1 more source

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Overproduction of tropane alkaloids in transgenic Hyoscyamus reticulatus hairy roots L. elicited by silicon dioxide nanoparticles and precursor feeding by phenylalanine and putrescine. [PDF]

Sci Rep
Hamdami N, Hosseini B, Hedayati A, Hasani M.   +3 more
europepmc   +1 more source

Debneyol decoded: A metabolic organizer powers broad‐spectrum plant defense

New Plant Protection, EarlyView.
Abstract A new Cell study by Wang et al. resolves the long‐elusive biosynthesis and regulation of debneyol, a fungicidal sesquiterpenoid phytoalexin in Solanaceae. The authors define the complete three‐step route from farnesyl pyrophosphate to debneyol and identify the small protein MCD1 as a metabolic organizer that assembles a multienzyme complex to ...
Shaojie Han
wiley   +1 more source

Avoiding False Identification of 7-Hydroxymitragynine in Kratom Products Using a Multicriteria LC-MS Confirmation. [PDF]

J Am Soc Mass Spectrom
Sheehan D, Li Y, Meckler E, Upton R, Zhang M.   +4 more
europepmc   +1 more source

A recipe for recovery: diet as a decisive tool in species conservation

Oikos, EarlyView.
Animals consume foods in specific quantities and ratios to meet a multi‐dimensional nutrient target that maximizes their fitness. Attempts to reach this target in an ever‐changing nutritional landscape often influence animal foraging behavior, habitat choice, and food‐web interactions. Consequently, understanding the nutritional ecology of a species is
Noa Lavie, Yael Levinson, Jessica M. Rothman, Dror Hawlena   +3 more
wiley   +1 more source

Salutaridine and its derivatives as thebaine-equivalents in the synthesis of aporphines

Open Chemistry, 2013
Udvardy Antal, Sipos Attila
doaj   +1 more source

Chemical Constituents, Pharmacological Activities, and Cardiovascular Protective Mechanisms of <i>Dendrobium</i> Species: A Review. [PDF]

Int J Mol Sci
Hu Y, Li Z, Li J, Li X, Wang M.
europepmc   +1 more source