Results 171 to 180 of about 157,429 (315)

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

Nicotine Tob Res [PDF]

IntroductionElectronic cigarette (e-cigarette) use is increasing dramatically in developed countries, but little is known about these rapidly evolving products.

core  

Pharmacokinetics and Acute Safety Evaluation of Tryptanthrin, A Bioactive Constituent of Indigo naturalis, Following Intravenous Administration in Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT The use of Indigo naturalis in treating inflammatory diseases is clinically restricted by severe adverse events, including pulmonary arterial hypertension and hepatotoxicity. Tryptanthrin, a major indoloquinazoline alkaloid of Indigo naturalis, exhibits potent anti‐inflammatory activity; however, its specific safety profile relative to the ...
Hyung Jin Kim, Gabsik Yang, Jun Ho Lee
wiley   +1 more source

Opium trade and use during the Late Bronze Age: Organic residue analysis of ceramic vessels from the burials of Tel Yehud, Israel

Archaeometry, EarlyView., 2022
Abstract Organic residue analysis was conducted on various vessels from burials at Tel Yehud, Israel. The analyses led to new reliable evidence for the presence of opioid alkaloids and their decomposition products. This research revitalizes a decades‐old discussion on the presence and function of the opium trade across a cultural region of utmost ...
Vanessa Linares, Eriola Jakoel, Ron Be’eri, Oded Lipschits, Ronny Neumann, Yuval Gadot   +5 more
wiley   +1 more source

Processing-induced detoxification of toxic Traditional Chinese Medicines: a systematic review of attenuation mechanisms at physical, chemical, and in vivo levels. [PDF]

Chin Med
Zhang W, Zhang Z, Bian Z, Zuo Q, Quan X, Gong J, Ju B, Feng L, Jia X, Yang B.   +9 more
europepmc   +1 more source

Cytochrome P450-based toxicity research of Pyrrolizidine alkaloids

, 2007
Pyrrolizidine alkaloids were considered as the essential components in the toxicity of some composite plants. The previous study suggested that cytochrome P450 (CYPs)–mediated bioactivation and succedent formation of DNA adducts triggered toxicity of ...
张江伟, 何芋岐, 刘勇, 杨凌, 杨丽, 王峥涛   +5 more
core  

Biochemical and Molecular Insights Into Monocrotaline‐Induced Hepatotoxicity: An Experimental Mouse Study

Journal of Applied Toxicology, EarlyView.
ABSTRACT Monocrotaline (MCT), a plant‐derived pyrrolizidine alkaloid, is well known for its hepatotoxic effects. However, full elucidation of the mechanisms underlying MCT‐induced hepatotoxicity, as well as the development of reliable biomarkers for early detection and monitoring, requires an integrated evaluation of biochemical, molecular, and ...
Ali Şenol, Alparslan Kadir Devrim, Miyase Çinar, Mahmut Sözmen, Fatma Betül Akça   +4 more
wiley   +1 more source

Morpho‐Anatomical and HPTLC Investigations of Lysimachia nummularia L. (Primulaceae) Grown in Switzerland

Microscopy Research and Technique, EarlyView.
This research provides a complete morphoanatomical description of Lysimachia nummularia, as well as a HPTLC profile. Standard techniques of light and scanning electron microscopies, as well as standard techniques of HPTLC, were used. ABSTRACT Primulaceae are distributed all over the world, encompassing around 2590 species.
Carolina Sabedotti, João Vitor da Costa Batista, Bettina Leonhard, Konrad Urech, Mahsa Ahmadinezhad, Jakob Maier, Stephan Baumgartner, Fabio Boylan, Carla Holandino, Jane Manfron   +9 more
wiley   +1 more source

Identification of key genes governing diester alkaloid biosynthesis in different tissues of Aconitum kusnezoffii. [PDF]

Front Plant Sci
Wu R, Fu Q, Wu Y, E E, Sa Q, Bao G, Bai S.   +6 more
europepmc   +1 more source

Eco‐Friendly Surfactants From Pithecellobium dulce: Extraction, Characterization and Surface Activity

Journal of Surfactants and Detergents, EarlyView.
Schematic representation of the comprehensive analysis of saponins extracted form of Pithecellobium dulce (Roxb.) Benth. ABSTRACT The widespread use of synthetic surfactants in industrial and domestic applications has raised environmental concerns due to their biodegradability and ecological issues.
Susmita Gudulkar, Bijaideep Dutta, Himanshu Dawda, Usha Mukundan, K. C. Barick   +4 more
wiley   +1 more source