Results 191 to 200 of about 435,947 (354)

Online real-time mass spectrometry-driven dynamic monitoring and optimal endpoint prediction schema development for herbal medicine decoction process. [PDF]

Chin Med
Wu J, Kang L, Hua Y, Li X, Qiu Z, Huang L.   +5 more
europepmc   +1 more source

Imidazole Alkaloids Epiisopilosine and Epiisopiloturine Attenuate Acetaminophen-Induced Liver Toxicity in Mice via Autophagy Modulation and Anti-Inflammatory Effects. [PDF]

J Biochem Mol Toxicol
de Oliveira AP, Pacheco G, Lopes ALF, da Silva Araujo AK, de Sousa Chaves L, de Araújo S, de Sousa Lima EB, Alves EHP, Queiroz-Junior CM, Teixeira MM, Costa VV, Souza JMT, Barros AB, de Araujo Sousa PS, Rocha JA, Araújo AJ, Filho JDBM, Véras LMC, Vasconcelos DFP, Medeiros JVR.   +19 more
europepmc   +1 more source

Systemic anti‐cancer therapy associated with the occurrence of peripheral neurotoxicity and, specifically, peripheral neuropathy

International Journal of Cancer, EarlyView.
What's New? While the effectiveness of systemic anticancer therapy is well documented, it commonly causes severe toxicity. This study of the 467 systemic anticancer therapy agents currently approved globally for clinical and/or research purposes found that peripheral neurotoxicity is associated with 45% of classical chemotherapies, 21% of targeted ...
Cassie Higgins, Lynn R. Gauthier, Blair H. Smith, Lesley Colvin   +3 more
wiley   +1 more source

Indole Alkaloids as Biased Opioid Receptor Modulators. [PDF]

Pharmaceuticals (Basel)
Grundmann O, Henderson A.
europepmc   +1 more source

Metabolic Signatures and Diagnostic Prediction Models for Coronary Artery Disease and Type 2 Diabetes Mellitus: Insights From an Exploratory Study

iNew Medicine, EarlyView.
Metabolomic & lipidomic analysis reveals metabolic overlap between CAD & T2DM, highlighting 7 key metabolites as potential biomarkers. A predictive model based on these achieves high accuracy, potentially advancing precision medicine & metabolic insights.
Zhihua Wang, Meiming Su, Ying Li, Yapei Li, Shuo Chen, Ting Peng, Hans Strijdom, Jiangang Wang, Jianping Weng, Suowen Xu   +9 more
wiley   +1 more source

Lack of tetrodotoxin analogues and individual metabolomic profiling of the cryptic frog Colostethus imbricolus. [PDF]

PLoS One
Gonzalez M, Palacios-Rodriguez P, Carazzone C.   +2 more
europepmc   +1 more source

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

Phytochemical Analysis of Veratrum Alkaloids in Medicinal Veratrum Globules Using High-Performance Liquid Chromatography Coupled With Tandem Mass Spectrometry. [PDF]

Biomed Chromatogr
Siegle J, Pietsch J.
europepmc   +1 more source

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Oral Rhizoma Coptis Alkaloids Nanoparticle for Treating Diabetes Through Regulating PI3K/Akt Pathways. [PDF]

Pharmaceutics
Liu Y, Zhu M, Su Q, Liu M, Zhao Z, Ma P.
europepmc   +1 more source