Results 71 to 80 of about 157,429 (315)

Intracellular Accumulation as an Indicator of Cytotoxicity to Screen Hepatotoxic Components of Chelidonium majus L. by LC–MS/MS

Molecules, 2019
A novel strategy was developed to identify hepatotoxic compounds in traditional Chinese medicines (TCMs). It is based on the exposure of HL-7702 cells to a TCM extract, followed by the identification and further determination of potential hepatotoxic ...
Cuiting Wu, Xin Wang, Ming Xu, Youping Liu, Xin Di   +4 more
doaj   +1 more source

Asymmetrische α‐Alkylierung mit aktivierten und unaktivierten Elektrophilen durch einen hocheffizienten und rezyklierbaren Lewis‐Säure/Imidazolium‐Katalysator

Angewandte Chemie, EarlyView.
Ein luftstabiler, einfach herzustellender bifunktioneller Cu(II)/Imidazolium‐Komplex ermöglicht hoch enantioselektive α‐Alkylierungen von 1,3‐Dicarbonylverbindungen mit herausragender Produktivität (TON bis zu 1740). Zu den hervorzuhebenden Merkmalen zählen ein breites Elektrophilspektrum, das sowohl π‐aktivierte als auch nicht aktivierte Reagenzien ...
Johanna Haußmann, Alexander Beck, Dominik Hornung, Michael Mistele, Alexander Allgaier, Wolfgang Frey, Joris van Slageren, Johannes Kästner, René Peters   +8 more
wiley   +1 more source

Neuroprotective Potential of Secondary Metabolites from Melicope lunu-ankenda (Rutaceae)

Molecules, 2019
Plant natural compounds have great potential as alternative medicines for preventing and treating diseases. Melicope lunu-ankenda is one Melicope species (family Rutaceae), which is widely used in traditional medicine, consumed as a salad and a food ...
Zeinab Abdulwanis Mohamed, Enas Mohamed Eliaser, Emanuela Mazzon, Patrick Rollin, Gwendoline Cheng Lian Ee, Ahmad Faizal Abdull Razis   +5 more
doaj   +1 more source

Neuroprotective Activities of Boophone haemanthoides (Amaryllidaceae) Extract and Its Chemical Constituents

Molecules, 2020
Parkinson’s disease (PD) is a neurodegenerative condition that progresses as age increases, and some of its major symptoms include tremor and postural and movement-related difficulties.
Abobaker S. Ibrakaw, Sylvester I. Omoruyi, Okobi E. Ekpo, Ahmed A. Hussein   +3 more
doaj   +1 more source

The Stemona Alkaloids

, 2015
The Stemonaceae (order Dioscoreales) is a small, monocotyledonous family with three small genera: Croomia (Southeastern North America and Japan), Stemona (Southeast Asia through Malaysia to North Australia), and Stichoneuron (Southeast Asia, including ...
De Oliveira M.D.C.F., Rosso G.B., Pilli R.A.   +2 more
core   +1 more source

Simplexidine, a 4-Alkylpyridinium Alkaloid from the Caribbean Sponge Plakortis simplex

Molecules, 2008
Chemical analysis of the secondary metabolites of the Caribbean sponge Plakortis simplex, a source of many bioactive compounds, showed the presence of the new metabolite simplexidine (4), belonging to the extremely rare class of 4-alkyl-pyridinium ...
Orazio Taglialatela-Scafati, Fernando Scala, Adriana Romano, Ernesto Fattorusso   +3 more
doaj   +1 more source

Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation

Antioxidants, 2020
Wide experimental evidence has been provided in the last decade concerning the neuroprotective effects of phytochemicals in a variety of neurodegenerative disorders.
Fiona Limanaqi, Francesca Biagioni, Federica Mastroiacovo, Maico Polzella, Gloria Lazzeri, Francesco Fornai   +5 more
doaj   +1 more source

Tropane alkaloids in food

, 2010
A large number of wild and cultured plants produce secondary metabolites that are toxic to humans and animals. Through accidental or intentional mixing of these plants with normal food and feed the consumers of these products will be exposed to the ...
Adamse, P., Egmond, H.P., van
core  

Antiangiogenic Alkaloids from Plants

, 2013
Angiogenesis, the formation of new blood vessels from preexisting capillaries, is an important research field. As the understanding of this process increases, this new knowledge will have a significant impact on several angiogenesisdependent diseases.
Soares, Raquel, Lopes, Flávia Cristine Mascia, Flávia Cristine Mascia Lopes, Luis Octávio Regasini, de Magalhães Pinheiro Alçada, Manuel Nuno, Manuel Nuno de Magalhães Pinheiro Alçada, Regasini, Luis Octávio [UNESP], Raquel Soares   +7 more
core   +1 more source

Asymmetric α‐Alkylation With Activated and Unactivated Electrophiles by a Highly Productive and Recyclable Lewis Acid/Imidazolium Catalyst

Angewandte Chemie International Edition, EarlyView.
An air‐stable, easily prepared, bifunctional Cu(II)/imidazolium complex enables highly enantioselective α‐alkylation of 1,3‐dicarbonyls with outstanding productivity (TON up to 1740). Highlights include broad electrophile scope spanning π‐activated and nonactivated reagents, stereo‐retentive allylation, simple catalyst synthesis, and efficient catalyst
Johanna Haußmann, Alexander Beck, Dominik Hornung, Michael Mistele, Alexander Allgaier, Wolfgang Frey, Joris van Slageren, Johannes Kästner, René Peters   +8 more
wiley   +1 more source