Results 81 to 90 of about 184,232 (306)

Neuroprotective Activities of Boophone haemanthoides (Amaryllidaceae) Extract and Its Chemical Constituents

Molecules, 2020
Parkinson’s disease (PD) is a neurodegenerative condition that progresses as age increases, and some of its major symptoms include tremor and postural and movement-related difficulties.
Abobaker S. Ibrakaw, Sylvester I. Omoruyi, Okobi E. Ekpo, Ahmed A. Hussein   +3 more
doaj   +1 more source

Investigations of Natural Products from Bryozoa Inhabiting Aotearoa New Zealand [PDF]

, 2012
Two species of bryozoa, Pterocella vesiculosa and Plumatella repens, were investigated in an endeavour to isolate and characterise novel secondary metabolites.
Andersen, Aaron John Christian
core  

Enzymatic formation of protopines by a microsomal cytochrome P-450 system of Corydalis vaginans [PDF]

, 1987
A microsomal cytochrome P-450-NADPH dependent enzyme which hydroxylates stereo- and regiospecifically carbon atom 14 of (S)- -N- methyltetrahydroprotoberberines has been discovered in a number of plant cell cultures originating from species containing ...
M.H. Zenk, Rüffer, Martina, Zenk, Meinhart H., M. Rueffer   +3 more
core   +1 more source

Cross‐Organ Multi‐Omics Profiling of Systemic Alterations in 5xFAD Mice and Changes Associated with Huanglian Jiedu Decoction Treatment

Advanced Science, EarlyView.
Cross‐organ multi‐omics reveals coordinated inflammatory and metabolic disturbances in 5xFAD mice. Huanglian Jiedu Decoction improves cognition and alleviates brain and liver abnormalities. Complementary hepatocyte–microglia conditioned‐medium experiments suggest PPAR‐γ involvement in treatment‐associated changes in microglial inflammation, providing ...
Wenya Gao, Jing Gao, Xiaohui Su, Xiangying Kong, Xiaolu Wei, Tunan Ding, Tiantian Guo, Shuangrong Gao, Yanyan Zhou, Junyi Zhou, Haiyu Zhao   +10 more
wiley   +1 more source

Simplexidine, a 4-Alkylpyridinium Alkaloid from the Caribbean Sponge Plakortis simplex

Molecules, 2008
Chemical analysis of the secondary metabolites of the Caribbean sponge Plakortis simplex, a source of many bioactive compounds, showed the presence of the new metabolite simplexidine (4), belonging to the extremely rare class of 4-alkyl-pyridinium ...
Orazio Taglialatela-Scafati, Fernando Scala, Adriana Romano, Ernesto Fattorusso   +3 more
doaj   +1 more source

Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation

Antioxidants, 2020
Wide experimental evidence has been provided in the last decade concerning the neuroprotective effects of phytochemicals in a variety of neurodegenerative disorders.
Fiona Limanaqi, Francesca Biagioni, Federica Mastroiacovo, Maico Polzella, Gloria Lazzeri, Francesco Fornai   +5 more
doaj   +1 more source

The Chemical Synthesis and Applications of Tropane Alkaloids

, 2019
Tropanes are an important class of alkaloid natural products that are found in plants all over the world. These compounds can exhibit significant biological activity and are among the oldest known medicines.
Wei-Wei Liao, Afewerki, Samson,, Armando Córdova, Samson Afewerki, Jia-Xin Wang, Cordova, Armando,, Liao, W. -W,, Wang, J. -X,   +7 more
core   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

In vitro action of plant extracts on Botrytis gladiolorum

Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 1998
The in vitro effect of extacts from Berberis vulgaris and Chelidonium majus was studied against Botrytis gladiolorum fungus isolated from Gladiolus spp.
Marcel PARVU
doaj   +1 more source

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source