Results 61 to 70 of about 157,429 (315)

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

open access: yesAdvanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang   +9 more
wiley   +1 more source

Influence of Nonpolar Substances on the Extraction Efficiency of Six Alkaloids in Zoagumhwan Investigated by Ultra Performance Liquid Chromatography and Photodiode Array Detection

open access: yesMolecules, 2012
A reverse phase ultra performance liquid chromatography and photodiode array (UPLC-PDA) detection method was established for the determination of six alkaloids in Zoagumhwan (ZGW), and further for investigating the influence of nonpolar substances on the
Shijing Liu   +9 more
doaj   +1 more source

Radical Approaches to Alangium and Mitragyna Alkaloids [PDF]

open access: yes, 2010
The work presented in this thesis has focused on the development of novel and concise syntheses of Alangium and Mitragyna alkaloids, and especial approaches towards (±)-protoemetinol (a), which is a key precursor of a range of Alangium alkaloids such as ...
Palframan, M J
core  

Pavine and isopavine alkaloids

open access: yes, 1987
Pavines and isopavines are two relatively small subgroups of the isoquinoline alkaloids, represented by 22 and 11 compounds, respectively. This chapter describes the occurrence and structure elucidation, synthesis, unnatural pavines and isopavines ...
Belkis Gözler, Gözler B.
core   +1 more source

Citrus aurantium honey‐mediated gut homeostasis and anti‐inflammation via Thorl/Nprl2‐TORC1 signaling: Network pharmacology and Drosophila validation

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The study employed a four‐tiered strategy: (1) UHPLC‐FTMS profiling of Citrus aurantium honey to characterize its chemical composition; (2) network pharmacology analysis integrating target prediction, protein–protein interaction networks, and KEGG pathway enrichment to identify the Thor1/Nprl2‐TORC1 axis as a key mechanistic pathway; (3) in vitro ...
Wenqi Wan   +6 more
wiley   +1 more source

PLANTS OF GENERA GENISTA L. AS PROMISING SOURCES OF PLANT RAW MATERIALS FOR THE CREATION OF NEW DRUG

open access: yesРазработка и регистрация лекарственных средств, 2019
The review presents the geographical distribution, botanical description, chemical composition, information about the use in medicine and the study of the pharmacological activity of the representatives of the genus Genista L. It is shown that the plants
E. V. Zhokhova   +2 more
doaj  

The Use of Bio-Guided Fractionation to Explore the Use of Leftover Biomass in Dutch Flower Bulb Production as Allelochemicals against Weeds

open access: yesMolecules, 2013
A major problem in flower bulb cultivation is weed control. Synthetic herbicides are mainly used, although they cause a range of problems, and integrated weed control through application of naturally occurring allelochemicals would be highly desirable ...
Rob Verpoorte   +4 more
doaj   +1 more source

Betaine and Isoquinoline Alkaloids Protect against Heat Stress and Colonic Permeability in Growing Pigs

open access: yesAntioxidants, 2020
Heat stress (HS) compromises productivity of pork production, in part as a result of increased oxidative stress and inflammatory responses, particularly within the gastrointestinal tract.
Hieu Huu Le   +10 more
doaj   +1 more source

The Chemical Synthesis and Applications of Tropane Alkaloids

open access: yes, 2019
Tropanes are an important class of alkaloid natural products that are found in plants all over the world. These compounds can exhibit significant biological activity and are among the oldest known medicines.
Wei-Wei Liao   +7 more
core   +1 more source

Enzymatic formation of protopines by a microsomal cytochrome P-450 system of Corydalis vaginans [PDF]

open access: yes, 1987
A microsomal cytochrome P-450-NADPH dependent enzyme which hydroxylates stereo- and regiospecifically carbon atom 14 of (S)- -N- methyltetrahydroprotoberberines has been discovered in a number of plant cell cultures originating from species containing ...
M.H. Zenk   +3 more
core   +1 more source

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