Results 131 to 140 of about 3,982 (151)

A DFT Study of Nucleobase Dealkylation by the DNA Repair Enzyme AlkB

The Journal of Physical Chemistry B, 2009
Oxidative dealkylation is a unique mechanistic pathway found in the alpha-ketoglutarate-Fe(II)-dependent AlkB family of enzymes to remove the alkylation damage to DNA bases and regenerate nucleobases to their native state. The B3LYP density functional combined with a self-consistent reaction field was used to explore the triplet, quintet, and septet ...
Haining, Liu, Jorge, Llano, James W, Gauld   +2 more
openaire   +2 more sources

Conformational Dynamics of Dioxygenase AlkB and DNA in the Course of Catalytically Active Enzyme–Substrate Complex Formation

Russian Journal of Bioorganic Chemistry, 2019
Fe2+/2-ketoglutarate-dependent DNA-dioxygenase AlkB from Escherichia coli is able to restore the native structure of alkylated DNA bases. The enzymatic process utilizes the molecular oxygen, and proceeds through a mechanism of oxidative dealkylation. Here, the kinetics of conformational changes of AlkB and DNA substrates in the course of binding steps ...
L. Y. Kanazhevskaya, D. A. Smyshlyaev, I. V. Alekseeva, O. S. Fedorova   +3 more
openaire   +1 more source

Computational Insights into the Non-Heme Diiron Alkane Monooxygenase Enzyme AlkB: Electronic Structures, Dioxygen Activation, and Hydroxylation Mechanism of Liquid Alkanes

Inorganic Chemistry
Alkane monooxygenase (AlkB) is a membrane-spanning metalloenzyme that catalyzes the terminal hydroxylation of straight-chain alkanes involved in the microbially mediated degradation of liquid alkanes. According to the cryoEM structures, AlkB features a unique multihistidine ligand coordination environment with a long Fe-Fe distance in its active center.
Yue Wang, Yongjun Liu
openaire   +2 more sources

pH effects on oxidative modification of alkylative DNA adducts by the AlkB-family enzymes

2021
Yitzai Chen, Deyu Li, Rui Qi, Xin Bush, Vincent Falkowski, Samuel Howarth   +5 more
openaire   +1 more source

Sequence Dependent Repair of 1,N6-Ethenoadenine by DNA Repair Enzymes ALKBH2, ALKBH3, and AlkB

Molecules, 2021
Deyu Li, Ke Bian, Li Deyu
exaly  

Metallocenter characterization of AlkB, a mononuclear non-heme Fe(II) DNA repair enzyme

Journal of Inorganic Biochemistry, 2003
Robert P. Hausinger, John McCracken, Timothy F. Henshaw   +2 more
openaire   +1 more source

Quantum Mechanics/Molecular Mechanics Study on the Oxygen Binding and Substrate Hydroxylation Step in AlkB Repair Enzymes

Chemistry - A European Journal, 2014
Matthew Quesne, Devesh Kumar, Reza Latifi   +2 more
exaly  

Structural determinants of nucleobase modification recognition in the AlkB family of dioxygenases

DNA Repair, 2020
Johan Robben, Vincent Van Deuren, Sander Plessers   +2 more
exaly  

Faculty Opinions recommendation of Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2006
openaire   +2 more sources

Detection and transcription of n-alkane biodegradation genes (alkB) in the genome of a hydrocarbon-oxidizing bacterium Geobacillus subterraneus K

Microbiology, 2011
Tamara Nazina, Tourova T P, Shestakova N M   +2 more
exaly