Results 51 to 60 of about 3,982 (151)

Changes of m6A modification in arsenic-induced oxidative stress of human embryonic lung fibroblasts

环境与职业医学, 2022
BackgroundArsenic can be toxic to human by triggering oxidative stress, which is companied by epigenetic modifications.ObjectiveTo investigate the modification of N6-methyladenosine (m6A) in human embryonic lung fibroblasts (HELF) during oxidative stress
Jingjing ZHENG, Zhao ZHAO, Jiajing ZHANG, Suhua WANG, Ning BU, Xuemin SHI, Yuhang ZHAO   +6 more
doaj   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, EarlyView.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Dealkylation of Macromolecules by Eukaryotic α-Ketoglutarate-Dependent Dioxygenases from the AlkB-like Family

Current Issues in Molecular Biology
Alkylating modifications induced by either exogenous chemical agents or endogenous metabolites are some of the main types of damage to DNA, RNA, and proteins in the cell.
Anastasiia T. Davletgildeeva, Nikita A. Kuznetsov   +1 more
doaj   +1 more source

Oncometabolite D-2-Hydroxyglutarate Inhibits ALKBH DNA Repair Enzymes and Sensitizes IDH Mutant Cells to Alkylating Agents

Cell Reports, 2015
Chemotherapy of a combination of DNA alkylating agents, procarbazine and lomustine (CCNU), and a microtubule poison, vincristine, offers a significant benefit to a subset of glioma patients.
Pu Wang, Jing Wu, Shenghong Ma, Lei Zhang, Jun Yao, Katherine A. Hoadley, Matthew D. Wilkerson, Charles M. Perou, Kun-Liang Guan, Dan Ye, Yue Xiong   +10 more
doaj   +1 more source

LINC00659 cooperated with ALKBH5 to accelerate gastric cancer progression by stabilising JAK1 mRNA in an m6A‐YTHDF2‐dependent manner

Clinical and Translational Medicine, 2023
Background N6‐methyladenosine (m6A) RNA modification is known as a common epigenetic regulation form in eukaryotic cells. Emerging studies show that m6A in noncoding RNAs makes a difference, and the aberrant expression of m6A‐associated enzymes may cause
Yuan Fang, Xi Wu, Yunru Gu, Run Shi, Tao Yu, Yutian Pan, Jingxin Zhang, Xinming Jing, Pei Ma, Yongqian Shu   +9 more
doaj   +1 more source

Protein Structuromics Reveals a Loop‐Controlled Half‐Open Active Pocket Conformation Throughout Fe(II)/α‐ketoglutarate‐Dependent Dioxygenase Catalytic Cycle

Advanced Science, Volume 13, Issue 47, 24 August 2026.
This study reveals a conserved half‐open active pocket in Fe(II)/α‐ketoglutarate‐dependent dioxygenases through protein structuromics, distinguished by structural features comprising highly flexible loop elements. Enhanced sampling simulations‐guided mutagenesis experiments elucidated how this flexible loop regulates pocket open/closed conformations ...
Lunjie Wu, Huan Liu, Songyin Zhao, Lei Qin, Jiarui Li, Jun Wang, Zixuan Dai, Jie Gu, Yan Xu, Feiran Li, Yao Nie   +10 more
wiley   +1 more source

Molecular Detection and Phylogenetic Analysis of the alkB Gene in Klebsiella oxytoca Strains Isolated from the Gut of Tenebrio molitor

The Scientific World Journal
The challenge in polystyrene disposal has caused researchers to look for urgent innovative and ecofriendly solutions for plastic degradation. Some insects have been reported to use polystyrene as their sole carbon source, and this has been linked to the ...
Tsitsi Lynn Mupamhadzi, Oleen Machona, Farisai Chidzwondo, Rumbidzai Mangoyi   +3 more
doaj   +1 more source

The effects of 2-hydroxyglutarate on the tumorigenesis of gliomas

Contemporary Oncology, 2018
Mutation of the isocitrate-dehydrogenase (IDH) enzymes is one of the central research topics regarding gliomagenesis. Indeed, 70% of gliomas are associated with a gain-of-function IDH mutation and consequently synthesize the oncometabolite, 2 ...
Cara Reiter-Brennan, Lukas Semmler, Andreas Klein   +2 more
doaj   +1 more source

Lipid metabolism and m6A RNA methylation are altered in lambs supplemented rumen-protected methionine and lysine in a low-protein diet

Journal of Animal Science and Biotechnology, 2022
Background Methionine or lysine has been reported to influence DNA methylation and fat metabolism, but their combined effects in N6-methyl-adenosine (m6A) RNA methylation remain unclarified.
Kefyalew Gebeyew, Chao Yang, Hui Mi, Yan Cheng, Tianxi Zhang, Fan Hu, Qiongxian Yan, Zhixiong He, Shaoxun Tang, Zhiliang Tan   +9 more
doaj   +1 more source

Lysine l‐Lactylation: Bridging Metabolism, Chromatin and Disease

Cell Proliferation, Volume 59, Issue 8, August 2026.
Enzymatic regulation of KL‐la. The enzymatic regulation of KL‐la involves two distinct pathways for L‐lactate accumulation: intracellular production through glycolysis‐derived pyruvate conversion by lactate dehydrogenase (LDH) or direct cellular uptake via monocarboxylate transporters (MCTs). These L‐lactate pools fuel two distinct lactylation pathways—
Anoosha Malik, Muhammad Dilawar, Junguang Liao, Jie Zheng, Qitao Qian, Ming Xu, Sisi Lin, Xiaobo Zhu, Qiuwei Ge, Limin Jin, Guiqian Chen   +10 more
wiley   +1 more source