Smiles‐Truce Cascades Enable Heteroaryl Cyclopropane and Sultine Synthesis
Angewandte Chemie International Edition, EarlyView.A triple C─C cascade approach to the synthesis of heteroaryl cyclopropanes is described. The reaction is metal‐free, uses simple starting materials, and presents a new retrosynthetic approach for heteroaryl cyclopropane synthesis. A change of substituent creates a new route to sultines, under‐explored motifs in medicinal chemistry. Abstract We describe
Thomas Sephton +2 more
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INDUCTION OF MITOTIC CROSSING-OVER IN ASPERGILLUS NIDULANS BY BIFUNCTIONAL ALKYLATING AGENTS [PDF]
, 1963 G. Morpurgo
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The selectivity of action of alkylating agents and drug resistance. II. A comparison of the effects of alkylating drugs on growth inhibition and cell size in sensitive and resistant strains of the Yoshida ascites sarcoma. [PDF]
, 1969 Kenneth R. Harrap, Bridget T. Hill
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B cells and systemic sclerosis interstitial lung disease
Arthritis &Rheumatology, Accepted Article.Interstitial lung disease is an important complication of systemic sclerosis (SSc‐ILD) with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to FDA‐approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of interstitial lung diseases of other systemic autoimmune ...
Nina Goldman +2 more
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Metal‐Mediated Protein Engineering within Live Cells
Chemistry – An Asian Journal, Volume 20, Issue 6, March 17, 2025.This review discusses how metal ions can mediate protein modification within live cells. With its easy handling, rapid solubility, and ease of internalization within the cells, metal ions can be an excellent stimulus for many organic reactions needed within an intracellular medium, which can modify proteins and lead to applications in chemistry ...
Pritam Ghosh
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Growth Inhibitory and Haematological Effects of Alkylating Agents and Attempts at their Modification to give Greater Selectivity of Anti-Tumour Action [PDF]
, 1967 L. A. Elson
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Chemistry – An Asian Journal, EarlyView.A new visible light‐induced method is reported for the C3‐alkylation of imidazo[1,2‐a]pyrimidines and ‐pyridines with aryldiazoacetates. This protocol can be performed in open air and serves as a convenient entry to several known and new molecules. A formal synthesis of zolpidem is achieved by changing the alkylating agent to an appropriate hypervalent
Ronei M. S. Souza +6 more
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Case report: Therapy-related myeloid neoplasms in three pediatric cases with medulloblastoma
Frontiers in OncologyIntroductionMedulloblastoma is the most common malignant brain tumor in children, often requiring intensive multimodal therapy, including chemotherapy with alkylating agents.
Li Shun Mak +10 more
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