Results 111 to 120 of about 3,238,601 (165)
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The Impact of Commonly Used Alkylating Agents on Artifactual Peptide Modification.
Journal of Proteome Research, 2017Iodoacetamide is by far the most commonly used agent for alkylation of cysteine during sample preparation for proteomics. An alternative, 2-chloroacetamide, has recently been suggested to reduce the alkylation of residues other than cysteine, such as the
P. Hains, P. Robinson
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Alkylating agents for Waldenstrom's macroglobulinaemia
Cochrane Database of Systematic Reviews, 2009Waldenstrom's macroglobulinaemia (WM) is an uncommon B-cell lymphoproliferative disorder characterized by bone marrow infiltration and production of monoclonal immunoglobulin. Uncertainty remains if alkylating agents, such as chlorambucil, melphalan or cyclophosphamide, are an effective form of management.To assess the effects and safety of the ...
Taixiang Wu, Jianlong Tan, Kun Yang
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JAMA: The Journal of the American Medical Association, 1971
Eleven patients with malignant lymphoma had sperm counts done in the course of maintenance treatment with the alkylating agents chlorambucil or cyclophosphamide. Of the nine patients treated with chlorambucil, all had aspermia after treatment with doses ranging from 10.1 to 17.7 mg/kg of body weight.
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Eleven patients with malignant lymphoma had sperm counts done in the course of maintenance treatment with the alkylating agents chlorambucil or cyclophosphamide. Of the nine patients treated with chlorambucil, all had aspermia after treatment with doses ranging from 10.1 to 17.7 mg/kg of body weight.
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2008
Chapter 5 deals with antitumor alkylating agents and platinum complexes. We first explain how the selectivity of DNA alkylation is governed by steric effects and, especially, by the “soft” or “hard” electrophilic character of the alkylating species, following by a comment about the several types of effects that different alkylating agents induce on DNA
Carmen Avendaño, J. Carlos Menéndez
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Chapter 5 deals with antitumor alkylating agents and platinum complexes. We first explain how the selectivity of DNA alkylation is governed by steric effects and, especially, by the “soft” or “hard” electrophilic character of the alkylating species, following by a comment about the several types of effects that different alkylating agents induce on DNA
Carmen Avendaño, J. Carlos Menéndez
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Synthesis and Performance of a Biomimetic Indicator for Alkylating Agents.
Journal of Organic Chemistry, 20154-(4-Nitrobenzyl)pyridine (NBP) is a colorimetric indicator compound for many types of carcinogenic alkylating agents. Because of the similar reactivity of NBP and guanine in DNA, NBP serves as a DNA model.
Philip A Provencher, J. Love
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Toxicity of the Alkylating Agent Bendamustin [PDF]
, 1985 In acute toxicity studies the maximum tolerated dose (MTD), the LD50 and the LD100 of Bendamustin were determined in rats and mice after i.v. and oral administration. In a subchronic study male rats were given Bendamustin for 28 days at oral dose levels of 5, 10, 20 or 40 mg/kg/day.
Härtl A, Horn U, Güttner J, Hoffmann H
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Molecular Pharmacology, 2013
The benefit of cancer chemotherapy based on alkylating agents is limited because of the action of DNA repair enzymes, which mitigate the damage induced by these agents.
L. Jordheim +11 more
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The benefit of cancer chemotherapy based on alkylating agents is limited because of the action of DNA repair enzymes, which mitigate the damage induced by these agents.
L. Jordheim +11 more
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Pharmacology of dimethanesulfonate alkylating agents: busulfan and treosulfan
Expert Opinion on Drug Metabolism & Toxicology, 2013Introduction: Among the dimethanesulfonates, busulfan, in combination with other alkylating agents or nucleoside analogues, is the cornerstone of high-dose chemotherapy.
A. Galaup, A. Paci
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Aldehydes as Alkylating Agents for Ketones
Chemistry – A European Journal, 2019AbstractCommon and non‐toxic aldehydes are proposed as reagents for alkylation of ketones instead of carcinogenic alkyl halides. The developed reductive alkylation reaction proceeds in the presence of the commercially available ruthenium catalyst [(cymene)RuCl2]2(as low as 250 ppm) and carbon monoxide as the reducing agent.
Sofiya A. Runikhina +7 more
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Hybrid ligand-alkylating agents targeting telomeric G-quadruplex structures.
Organic and biomolecular chemistry, 2012The synthesis, physico-chemical properties and biological effects of a new class of naphthalene diimides (NDIs) capable of reversibly binding telomeric DNA and alkylate it through an electrophilic quinone methide moiety (QM), are reported.
F. Doria +11 more
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