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Mechanisms of Resistance to Alkylating Agents
1996A major problem in cancer chemotherapy is the frequently encountered rapid loss in responsiveness to therapeutic agents [1]. Drug resistance can be the result of the induction of a variety of protective mechanisms or the result of the selection of resistant clones.
Philip G. Penketh +2 more
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Chemosensitization by monofunctional alkylating agents
International Journal of Radiation Oncology*Biology*Physics, 1986The chemosensitizing ability of model monofunctional alkylating agents with known DNA base alkylating characteristics, that is, methylmethanesulphonate (MMS), ethyl methanesulphonate (EMS) and N-methyl-N-nitrosoguanidine (MNNG) have been investigated. Whereas the alkyl sulphonates chemosensitize V79 cells to cisplatin and melphalan, MNNG does not.
J.M. Walling, Ian J. Stratford
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Photogeneration and reactivity of naphthoquinone methides as purine selective DNA alkylating agents.
Journal of the American Chemical Society, 2010A one-step protecting-group-free synthesis of both 6-hydroxy-naphthalene-2-carbaldehyde and the bifunctional binaphthalenyl derivative afforded 6-hydroxymethylnaphthalen-2-ol, 6-methylaminomethyl-naphthalen-2-ol, [(2-hydroxy-3-naphthyl)methyl]trimethyl ...
D. Verga +7 more
semanticscholar +1 more source
Mechanisms of resistance to alkylating agents
1994The alkylating agents produce cytotoxicity by chemically reacting with cellular components that contain electron-rich nitrogen, sulfur, or oxygen atoms. A multitude of cellular constituents, including amino acids, nucleotides, proteins, nucleic acids, and cell membranes are alkylated by the therapeutic alkylating agents.
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Mechanisms of resistance to alkylating agents
1998Alkylating agents are the most widely used anticancer drugs whose main target is the DNA, although how exactly the DNA lesions cause cell death is still not clear. The emergence of resistance to this class of drugs as well as to other antitumor agents is one of the major causes of failure of cancer treatment.
Maurizio D'Incalci, Giovanna Damia
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Vestibulotoxic Effect of Alkylating Agents
ORL, 1977The vestibular sensory epithelia from 3 patients treated with cytotoxic drugs were studied with a surface specimen technique, 2 cases had been treated with cyclophosphamide and 1 with melphalan. In all 3 cases there was some slight degeneration affecting the cristae ampullares. The macula utriculi showed no signs of degeneration.
Ulf Rosenhall, Harald Nyman, Jan Stahle
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Alkylating agents: Mechanisms and modulation
1989The term alkylating agents encompasses a wide range of compounds that are capable of covalently modifying a variety of intracellular targets. The mechanism(s) by which alkylating agents kill human tumor cells has not been completely characterized and is therefore not fully understood.
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Sensing of Alkylating Agents Using Organic FieldâEffect Transistors
, 2010Alkylating agents are simple and reactive molecules that are commonly used in many and diverse fields, such as organic synthesis, medicine, and agriculture.
Yair Gannot +3 more
semanticscholar +1 more source
Quinone methides tethered to naphthalene diimides as selective G-quadruplex alkylating agents.
Journal of the American Chemical Society, 2009We have developed novel G-quadruplex (G-4) ligand/alkylating hybrid structures, tethering the naphthalene diimide moiety to quaternary ammonium salts of Mannich bases, as quinone-methide precursors, activatable by mild thermal digestion (40 degrees C ...
M. Di Antonio +7 more
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Scandinavian Journal of Haematology, 2009
A total of 120 patients with polycythaemia vera (PV) were observed between 1971-1976. 8 of them developed acute leukaemia (AL). The clinical course, cytogenetic and morphologic findings of these patients are described in detail.
A. Weinfeld +3 more
semanticscholar +1 more source
A total of 120 patients with polycythaemia vera (PV) were observed between 1971-1976. 8 of them developed acute leukaemia (AL). The clinical course, cytogenetic and morphologic findings of these patients are described in detail.
A. Weinfeld +3 more
semanticscholar +1 more source