Results 121 to 130 of about 86,457 (338)

Visible-light-induced reusable decatungstate-photocatalyzed radical cascade alkylation/cyclization of isocyanides with simple alkanes, ethers and ketones

Green Synthesis and Catalysis
With reusable sodium decatungstate (NaDT) as the photocatalyst, hydrocarbons (alkanes, ethers and ketones) as the alkylating agents, a wide range of alkylated fused N-heterocycles were obtained in high yield.
Ke-Li Wang, Hong-Tao Ji, Qiong-Hui Peng, Jun Jiang, Li-Juan Ou, Wei-Min He   +5 more
doaj   +1 more source

Câncer e agentes antineoplásicos ciclo-celular específicos e ciclo-celular não específicos que interagem com o DNA: uma introdução Cancer and cell cicle-specific and cell cicle nonspecific anticancer DNA-interactive agents: an introduction

Química Nova, 2005
The chemotherapy agents against cancer may be classified as "cell cycle-specific" or "cell cycle-nonspecific". Nevertheless, several of them have their biological activity related to any kind of action on DNA such as: antimetabolic agents (DNA synthesis ...
Vera Lúcia de Almeida, Andrei Leitão, Luisa del Carmen Barrett Reina, Carlos Alberto Montanari, Claudio Luis Donnici, Míriam Teresa Paz Lopes   +5 more
doaj   +1 more source

Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy [PDF]

, 2014
Phosphatase and tensin homolog (PTEN) loss is associated with genomic instability. APE1 is a key player in DNA base excision repair (BER) and an emerging drug target in cancer.
Allinson, Ashworth, Ashworth, Bertram, Bosenberg, Botti, Bristow, Burma, Campisi, Curtin, Eng, Eng, Foiani, Gerson, He, Helleday, Hickson, Kelley, Larue, Li, Madhusudan, Madhusudan, Madhusudan, Madhusudan, Maloney, Maloney, Meyskens, Newton-Bishop, Pandolfi, Pandolfi, Parsons, Polyak, Pu, Reis-Filho, Reis-Filho, Ribas, Rimm, Robertson, Rocha, Simeonov, Simeonov, Smalley, Stambolic, Stambolic, Teo, Wadhwa, Wilson, Wilson, Yin, Zhang   +49 more
core   +2 more sources

The cJun N-terminal kinase (JNK) signaling pathway mediates induction of urokinase-type plasminogen activator (uPA) by the alkylating agent MNNG [PDF]

, 2000
Maribel Parra, Frederic Lluı́s, Francesc Miralles, Carmé Caelles, Pura Muñoz‐Cánoves   +4 more
openalex   +1 more source

SIRT5–RAC2 Axis Drives Monocyte‐to‐Macrophage Differentiation to Promote Inflammatory Injury in Premature Ovarian Insufficiency

Advanced Science, EarlyView.
SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai, Yaqi Li, Shengnan Liu, Minjuan Wu, Zhixiao Liu, Junfeng Jiang, Jingjing Chen, Xiaoding Xu, Li Li, Chaoqun Li, Fang Zhao, Ye Liu, Haitao Ni, Tengfei Zhang, Mingjuan Xu, Chaofeng Han   +15 more
wiley   +1 more source

Electrochemistry of potentially bioreductive alkylating quinones : Part 1. Electrochemical properties of relatively simple quinones, as model compounds of mitomycin- and aziridinylquinone-type antitumour agents [PDF]

, 1990
The influence of methyl-, hydroxy and amino substituents on the electrochemical behaviour of simple 1,4-naphtho-and 1,4-benzoquinones, model compounds of many quinoid antitumour agents, in aqueous media was studied. Significant changes in electrochemical
Bos, M., Driebergen, R.J., Hartigh, J. den, Holthuis, J.J.M., Hulshoff, A., Linden, W.E. van der, Oort, W.J. van, Postma Kelder, S.J., Reinhoudt, D.N., Verboom, W.   +9 more
core   +2 more sources

The influence of alkylating agent MNNG on mutagenic effect of exogeneous recombinant DNA [PDF]

, 1995
Л. Л. Лукаш, S. V. Podolskaya, H. M. Suhorada, K. V. Kostetskaya, I. E. Kostetsky, I. S. Varzanova, Yu. V. Patskovsky, I. V. Vavilina, S. V. Deis   +8 more
openalex   +1 more source

Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling

Advanced Science, EarlyView.
Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu, Zhi‐Bin Hu, Ling Hu, Yu‐Bing Wang, Qiong Zhang, Ning‐Ning Song, Xi‐Yue Liu, Jia‐Yin Chen, Hong‐Wen Zhu, Bing‐Yao Zhou, Yun‐Chao Tao, Li Zhao, Ze‐Xuan Li, Yi‐Wei Li, Jia‐Qi Chen, Si‐Xin Tu, Cong‐Cong Qi, Sai‐Dan Ding, Gang Peng, Lin Xu, Yu‐Qiang Ding   +20 more
wiley   +1 more source

Substituted Cysteine Accessibility Method for Topology and Activity Studies of Membrane Enzymes Forming Thioester Acyl Intermediates in Bacteria

Bio-Protocol, 2015
The topology of membrane proteins and enzymes can be determined using various methods including reporter protein fusions and accessibility of cysteine residues to alkylating agents.
Sébastien Gélis-Jeanvoine, Nienke Buddelmeijer   +1 more
doaj   +1 more source

Comparison of the efficacy of carboplatin, oxaliplatin and cisplatin, with various concentrations of epidermal growth factor family ligands, in killing human triple-negative breast cancer cells [PDF]

, 2011
Current breast cancer therapies focus on the use of hormones to control tumor cells. However, triple negative breast cancers (TNBC) lack receptors for the hormones estrogen and progesterone, in addition to the HER-2 protein.
Blankenship, Elise
core