Results 11 to 20 of about 80,529 (226)

Polyphenols enhance the activity of alkylating agents in leukaemia cell lines. [PDF]

Oncotarget, 2019
Polyphenols have been shown to sensitize solid tumours to alkylating agents such as cisplatin, and induce apoptosis and/or cell-cycle arrest. Here, we assess the effects of five polyphenols alone and in combination with three alkylating agents: cisplatin,
Mahbub AA, Maitre CLL, Haywood-Small S, Cross NA, Jordan-Mahy N.   +4 more
europepmc   +3 more sources

Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapyinduced leukemia [PDF]

, 2001
Glutathione S-transferases (GSTs) detoxify potentially mutagenic and toxic DNA-reactive electrophiles, including metabolites of several chemotherapeutic agents, some of which are suspected human carcinogens.
Allan, J.M., Wild, C.P., Rollinson, S., Willett, E.V., Moorman, A.V., Dovey, G.J., Roddam, P.L., Roman, E., Cartwright, R.A., Morgan, G.J.   +9 more
core   +7 more sources

Balancing repair and tolerance of DNA damage caused by alkylating agents [PDF]

, 2012
Alkylating agents constitute a major class of frontline chemotherapeutic drugs that inflict cytotoxic DNA damage as their main mode of action, in addition to collateral mutagenic damage.
A Al-Attar, A Bapat, A Schambach, A Shibata, A Simeonov, AE Kiltie, AE Pegg, AH Trainer, AJ Deans, AS Jaiswal, AS Jaiswal, B Kaina, B Kaina, B Kaina, B Kaina, B Rydberg, B Sedgwick, BA Kunz, BJ Glassner, BJ Glassner, BP Engelward, BP Engelward, BP Engelward, C Fleischmann, CD Curtis, CD Mol, CE Ström, D Ravi, D Starcevic, D Svilar, D Wang, D Wilson, DC Cabelof, DR Duckett, Dragony Fu, DW Kufe, E Allay, E Allay, E Batts, E Jelezcova, F Calleja, F Drablos, F Mégnin-Chanet, GC Stachelek, GE Kisby, H Bartsch, H Farmer, H Interthal, H Kawate, HE Bryant, HY Hu, I Casorelli, I Kaasen, I Rusyn, J Dosch, J Jelinek, J Jiang, J Klapacz, J Klapacz, J Lips, J Paik, J Weingart, J-b Tang, JA Allay, JA Quinn, JB Sweasy, JC Huang, Jennifer A. Calvo, JH Robbins, JK Horton, JK Horton, JM Bugni, JM de Murcia, JS Reese, JS Reese, JS Reese, JT Hamilton, JW Cardinal, JY Choi, K Ballschmiter, K Becker, K Becker, K Becker, K Chan, K Ochs, K Sakumi, K Savitsky, K Takenaka, K-i Yoshioka, KH Almeida, KH Lauritzen, L Gate, L Haracska, L Haracska, L Haracska, L Liu, L Liu, L Liu, L Liu, L Mirabello, L Samson, L Wang, L Weissman, L Weissman, L Zecca, LA Loeb, LB Meira, LB Meira, Leona D. Samson, LJ Hofseth, LJ Rasmussen, LJ Reha-Krantz, LJ Stallons, LL Dumenco, LM Posnick, M Briegert, M Christmann, M Christmann, M Eich, M Hewish, M Jansen, M Koi, M Luo, M Rinne, M Rouleau, MA Lovell, ME Arana, ME Hegi, ME Moynahan, MJ Hickman, MJ Hickman, ML Fishel, ML Hegde, ML Rinne, MR Kelley, MS Bobola, MZ Zdzienicka, N Burns, N de Wind, N Mojas, N Shrivastav, N Valeri, NA Yamada, NH Zaidi, NJ Toft, NK Kim, OJ Sansom, OJ Sansom, OJ Sansom, OK Mirzoeva, OM Sieber, P Branch, P Cejka, P Hanawalt, P Monti, P Monti, P Moskwa, P Rajesh, P Taverna, P Taverna, PJ McKinnon, R Maze, R Maze, R Prasad, R Tsaryk, RB Roth, RC Fry, RE Johnson, RH Elder, RJ Hansen, RN Trivedi, RW Sobol, RW Sobol, RW Sobol, RW Sobol, S Freitas, S Hongeng, S Kakolyris, S Ragg, S Wilson, S Wirtz, SE Andrew, SF El-Khamisy, SR Cerda, SS Hecht, SS Lange, T Coquerelle, T Iida, T Iwakuma, T Izumi, T Moritz, T Neff, T Neff, T Tsuzuki, TF Gajewski, TJ Begley, TS Fenske, V Di Maso, V Poltoratsky, W Lutz, W Meikrantz, W Xiao, WP Roos, WP Roos, X Qin, X Qin, Y Jiang, Y Jiang, Y Kee, Y Lee, Y Nakatsuru, ZQ Zhou   +211 more
core   +1 more source

TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy [PDF]

, 2013
Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents.
Alagoz, Boyd, Breslin, Caldecott, Chen, Chiang, Ciccia, Dalhus, Das, Demple, Dungey, El-Khamisy, Fu, Godon, Hecht, Hegde, Hudson, Interthal, Interthal, Kato, Katyal, Kummar, Lebedeva, Lindahl, Lindahl, Liu, Loeb, Luo, Madhusudan, Meisenberg, Meryem Alagoz, Mohammed, Morland, Murai, Murai, Nilsen, Owen S. Wells, Pommier, Pourquier, Povirk, Ray Chaudhuri, Rydberg, Sherif F. El-Khamisy, Strom, Sultana, Takashima, Wilson, Xanthoudakis, Yang, Zeng, Zhou   +50 more
core   +1 more source

Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells. [PDF]

, 2014
BACKGROUND: The importance of the genetic background of cancer cells for the individual susceptibility to cancer treatments is increasingly apparent.
Arozarena, Imanol, Erice, O., Ferguson, J., Goicoechea, I., Margison, G.P., Wellbrock, C.   +5 more
core   +2 more sources

Restoration of Sensitivity in Chemo [PDF]

, 2013
Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. Despite multimodal treatments including surgery, chemotherapy and radiotherapy the prognosis remains poor and relapse occurs regularly.
Boxhammer, Veronika, Klämpfl, Tobias G., Köritzer, Julia, Li, Yang-Fang, Morfill, Gregor E., Schlegel, Jürgen, Schwenk-Zieger, Sabina, Schäfer, Andrea, Shimizu, Tetsuji, Welz, Christian, Zimmermann, Julia L.   +10 more
core   +1 more source

Microsomal superoxide anion production and NADPH-oxidation in a series of 22 aziridinylbenzoquinones [PDF]

, 1989
Several 2,5-bis(1-aziridinyl)-1,4-benzoquinones (BABQs) can be activated to alkylating species by reduction of the quinone moiety. On the other hand, cytotoxicity of these compounds can be induced by redox cycling.
Koster, Andries Sj., Prins, Bram, Reinhoudt, David N., Verboom, Willem   +3 more
core   +3 more sources

The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma [PDF]

, 2018
Background: The use of alkylating agents such as temozolomide in association with radiotherapy (RT) is the therapeutic standard of glioblastoma (GBM).
Chen, Yi, Colapietro, Alessandro, Cristiano, Loredana, Delle Monache, Simona, Festuccia, Claudio, Gravina, Giovanni Luca, Mancini, Andrea, Marampon, Francesco, Mehrling, Thomas, Pompili, Simona, Tombolini, Vincenzo, Vetuschi, Antonella, Vitale, Flora   +12 more
core   +2 more sources

Poly(thioether) vitrimers via transalkylation of trialkylsulfonium salts [PDF]

, 2017
Vitrimers are permanently cross-linked organic polymers that can be reshaped, molded, and recycled without loss of network integrity. Herein, we report poly(thioether) networks, prepared through a straightforward thiol-ene photopolymerization, that can ...
Hendriks, Benjamin, Waelkens, Jelle, Winne, Johan, Du Prez, Filip   +3 more
core   +1 more source

The Genetic Basis of Mutation Rate Variation in Yeast. [PDF]

, 2018
Mutations are the root source of genetic variation and underlie the process of evolution. Although the rates at which mutations occur vary considerably between species, little is known about differences within species, or the genetic and molecular basis ...
Bloom, Joshua S, Gou, Liangke, Kruglyak, Leonid   +2 more
core   +1 more source