Development of Syngeneic Murine Glioma Models with Somatic Mismatch Repair Deficiency to Study Therapeutic Responses to Alkylating Agents and Immunotherapy [PDF]
Curr ProtocDeepti Bhatt +5 more
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Persistence of DNA adducts, hypermutation and acquisition of cellular resistance to alkylating agents in glioblastoma [PDF]
Cancer Biol Ther, 2017 Richard Head +5 more
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MPTAC links alkylation damage signaling to sterol biosynthesis
Redox Biology, 2022 Overproduction of reactive oxygen species (ROS) drives inflammation and mutagenesis. However, the role of the DNA damage response in immune responses remains largely unknown.
Tamaki Suganuma, Jerry L. Workman
doaj +1 more source
Alkylating Agents Stronger than Alkyl Triflates [PDF]
Journal of the American Chemical Society, 2004 A new class of potent electrophilic "R(+)" alkylating agents has been developed using weakly nucleophilic carborane anions as leaving groups. These reagents, R(CHB(11)Me(5)X(6)) (R = Me, Et, and i-Pr; X = Cl, Br), are prepared via metathesis reactions with conventional alkylating agents such as alkyl triflates, using the high oxophilicity of silylium ...
Kato, Tsuyoshi +4 more
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Pseudomonas putida AlkA and AlkB proteins comprise different defense systems for the repair of alkylation damage to DNA - in vivo, in vitro, and in silico studies. [PDF]
PLoS ONE, 2013 Alkylating agents introduce cytotoxic and/or mutagenic lesions to DNA bases leading to induction of adaptive (Ada) response, a mechanism protecting cells against deleterious effects of environmental chemicals.
Damian Mielecki +9 more
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Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1. [PDF]
PLoS Genetics, 2013 Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues.
Jennifer A Calvo +10 more
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Biosynthesis of DNA-Alkylating Antitumor Natural Products
Molecules, 2022 DNA-alkylating natural products play an important role in drug development due to their significant antitumor activities. They usually show high affinity with DNA through different mechanisms with the aid of their unique scaffold and highly active ...
Qiu-Yue Nie +3 more
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Cell Reports, 2015 Chemotherapy of a combination of DNA alkylating agents, procarbazine and lomustine (CCNU), and a microtubule poison, vincristine, offers a significant benefit to a subset of glioma patients.
Pu Wang +10 more
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Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs. [PDF]
PLoS ONE, 2011 First line chemotherapeutics for brain tumors (malignant gliomas) are alkylating agents such as temozolomide and nimustine. Despite growing knowledge of how these agents work, patients suffering from this malignancy still face a dismal prognosis ...
Steve Quiros +2 more
doaj +1 more source
TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy [PDF]
, 2013 Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents.
Alagoz +50 more
core +1 more source