Mutation signatures specific to DNA alkylating agents in yeast and cancers. [PDF]
Nucleic Acids Res, 2020 Alkylation is one of the most ubiquitous forms of DNA lesions. However, the motif preferences and substrates for the activity of the major types of alkylating agents defined by their nucleophilic substitution reactions (SN1 and SN2) are still unclear ...
Saini N +8 more
europepmc +2 more sources
Temozolomide and Other Alkylating Agents in Glioblastoma Therapy. [PDF]
Biomedicines, 2019 The alkylating agent temozolomide (TMZ) together with maximal safe bulk resection and focal radiotherapy comprises the standard treatment for glioblastoma (GB), a particularly aggressive and lethal primary brain tumor.
Strobel H +7 more
europepmc +2 more sources
Mechanisms of Lymphoma Clearance Induced by High-Dose Alkylating Agents. [PDF]
Cancer Discov, 2019 The extraordinary activity of high-dose cyclophosphamide against some high-grade lymphomas was described nearly 60 years ago. Here we address mechanisms that mediate cyclophosphamide activity in bona fide human double-hit lymphoma.
Lossos C +23 more
europepmc +2 more sources
Polyphenols enhance the activity of alkylating agents in leukaemia cell lines. [PDF]
Oncotarget, 2019 Polyphenols have been shown to sensitize solid tumours to alkylating agents such as cisplatin, and induce apoptosis and/or cell-cycle arrest. Here, we assess the effects of five polyphenols alone and in combination with three alkylating agents: cisplatin,
Mahbub AA +4 more
europepmc +2 more sources
Decreased spermatogonial quantity in prepubertal boys with leukaemia treated with alkylating agents. [PDF]
Leukemia, 2017 Decreased spermatogonial quantity in prepubertal boys with leukaemia treated with alkylating ...
Poganitsch-Korhonen M +7 more
europepmc +2 more sources
Speciation of reactive sulfur species and their reactions with alkylating agents: do we have any clue about what is present inside the cell? [PDF]
Br J Pharmacol, 2019 BACKGROUND AND PURPOSE: Posttranslational modifications of cysteine residues represent a major aspect of redox biology, and their reliable detection is key in providing mechanistic insights.
Bogdándi V +14 more
europepmc +2 more sources
Alcohols as alkylating agents in heteroarene C-H functionalization. [PDF]
Nature, 2015 Redox processes and radical intermediates are found in many biochemical processes, including deoxyribonucleotide synthesis and oxidative DNA damage. One of the core principles underlying DNA biosynthesis is the radical-mediated elimination of H2O to ...
Jin J, Jin J, MacMillan DW.
europepmc +2 more sources
O6-Methylguanine DNA Methyltransferase Status Does Not Predict Response or Resistance to Alkylating Agents in Well-Differentiated Pancreatic Neuroendocrine Tumors. [PDF]
Pancreas, 2017 OBJECTIVES Alkylating agents have activity in well-differentiated pancreatic neuroendocrine tumors (WD panNETs). In glioblastoma multiforme, decreased activity of O-methylguanine DNA methyltransferase (MGMT) predicts response; in panNETs, MGMT relevance ...
Raj N +9 more
europepmc +2 more sources
Evolution of Nitrogen-Based Alkylating Anticancer Agents
Processes, 2021 Despite the significant progress in anticancer drug development over recent years, there is a vital need for newer agents with unique, but still effective, mechanisms of action in order to treat the disease, particularly the highly aggressive and drug ...
F. Lehmann, J. Wennerberg
semanticscholar +1 more source
Multiple glassy dynamics of a homologous series of triphenylene-based columnar liquid crystals -- A study by broadband dielectric spectroscopy and advanced calorimetry [PDF]
Journal of Molecular Liquids 358, 119212 (2022), 2022 Hexakis(n-alkyloxy)triphenylene) (HATn) consisting of an aromatic triphenylene core and alkyl side chains are model discotic liquid crystal (DLC) systems forming a columnar mesophase. In the mesophase, the molecules of HATn self-assemble in columns, which has one-dimensional high charge carrier mobility along the columns.
arxiv +1 more source