Results 51 to 60 of about 3,196,403 (286)
Advanced Healthcare Materials, EarlyView.A new oxaliplatin‐based Pt(IV) prodrug bearing a Mn(II) superoxide dismutase mimic is synthesized and studied, in vitro and in vivo, in the context of colorectal cancer. Encapsulation of this prodrug in an easy‐to‐implement PEGylated micelle formulation demonstrated the highest in vivo anticancer activity among all the tested conditions, supporting the
Alvaro Lopez‐Sanchez +14 more
wiley +1 more source
Advanced Materials, EarlyView.Nanoscale metal–organic frameworks (MOFs) and nanocellulose composites have significant potential for the multi‐functional remediation of the environment. This review focused on the synthesis strategies (in situ growth, ex situ growth, and other approaches), typical forms (aerogel, hydrogel, beads, and membrane), and applications in the removal of ...
Ye Song +13 more
wiley +1 more source
AntioxidantsAlkylating agents, historically employed as chemical warfare agents and currently used as chemotherapeutic drugs, are known to induce significant pulmonary toxicity. Current clinical interventions often fail to fully prevent or reverse these pathological
Emma Sola +4 more
doaj +1 more source
Cell Death and Disease, 2015 Microenvironment-mediated upregulation of the B-cell receptor (BCR) and nuclear factor-κB (NF-κB) signaling in CLL cells resident in the lymph node and bone marrow promotes apoptosis evasion and clonal expansion.
Cody Paiva +4 more
semanticscholar +1 more source
Advanced Materials, EarlyView.Platinum‐free hydrogen photocatalysis is achieved using dibenzothiophene‐S,S‐sulfoxide‐based conjugated polymers, self‐assembled into nanoparticles via nanoprecipitation. Through side chain engineering and donor–acceptor design, these materials reach a hydrogen evolution rate of 209 mmol g⁻¹ h⁻¹. The structure–function insights presented here establish
Alexandre Holmes +11 more
wiley +1 more source
Preferential Membrane Remodeling on Curved Biointerfaces Induced by Conjugated Oligoelectrolyte
Advanced Materials Interfaces, EarlyView.This study explores how membrane shape influences the interaction of conjugated oligoelectrolytes (COEs) with lipid bilayers. Using a curved biointerface composed of nanobar arrays and supported lipid bilayers, it is revealed that COE intercalation preferentially remodels curved regions, forming distinct structures. These findings highlight the role of
Xinwen Miao +7 more
wiley +1 more source
Short story of antirheumatic therapy.VIII. The immunodepressants
Reumatismo, 2012 The use of immunosuppressive drugs in rheumatology is fairly recent, starting just after the Second World War with the introduction of the first alkylating agents in oncohematology.
P. Marson, G. Pasero
doaj +1 more source
Cancer Discovery, 2014 UNLABELLED Alkylating agents are a first-line therapy for the treatment of several aggressive cancers, including pediatric glioblastoma, a lethal tumor in children. Unfortunately, many tumors are resistant to this therapy.
S. Agnihotri +20 more
semanticscholar +1 more source
Advanced Materials Technologies, EarlyView.A miniaturized microfluidic device is 3D printed via two‐photon polymerization and used for the droplet‐based microfluidic synthesis of nanogels for controlled drug delivery purposes. Tuning the fluid flow parameters, the microfluidic system enables the modulation of nanogel size and properties, preserving an extremely low polydispersity, beyond the ...
Vladimir Matining +8 more
wiley +1 more source
Etherification of Bio‐Based Furanic Compounds via Continuous Flow
Advanced Sustainable Systems, EarlyView.A comprehensive investigation on the etherification of bio‐based furanic compounds using a continuous flow apparatus. Reaction conditions are optimized for the synthesis of BEMF and then used to obtain a library of BAMFs. Additionally, the self‐etherification of HMF to produce OBMF is explored both in heterogeneous and by employing the homogeneous ...
Davide Dalla Torre +4 more
wiley +1 more source