Results 51 to 60 of about 86,457 (338)

Fertility preservation in gynaecologic cancers [PDF]

, 2018
Due to substantial improvement in the diagnosis and treatment of gynaecologic cancers, a better understanding of patient care needs to be revised. We reviewed the literature related to fertility preservation strategies in gynaecological cancer and ...
De Felice, Francesca, Di Pinto, Anna, Marchetti, Claudia, Musella, Angela, Muzii, Ludovico, Palaia, Innocenza, Panici, Pierluigi Benedetti, Porpora, Maria Grazia, Tomao, Federica, Tombolini, Vincenzo   +9 more
core   +1 more source

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, EarlyView.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

Glioblastoma under Siege: An Overview of Current Therapeutic Strategies

Brain Sciences, 2018
Glioblastoma is known to be one of the most lethal and untreatable human tumors. Surgery and radiotherapy in combination with classical alkylating agents such as temozolomide offer little hope to escape a poor prognosis.
Mayra Paolillo, Cinzia Boselli, Sergio Schinelli   +2 more
doaj   +1 more source

A Novel 3-Methyladenine DNA Glycosylase from Helicobacter pylori Defines a New Class within the Endonuclease III Family of Base Excision Repair Glycosylases [PDF]

, 2000
The cloning, purification, and characterization of MagIII, a 3-methyladenine DNA glycosylase from Helicobacter pylori, is presented in this paper. Sequence analysis of the genome of this pathogen failed to identify open reading frames potentially coding ...
Boiteux, Serge, Chevalier, Catherine, Ielpi, Luis, Labigne, Agnès, O'Rourke, Eyleen J., Radicella, Juan Pablo   +5 more
core   +1 more source

Proteins, Processing, and Properties of Adhesive Fluid Condensates Purified from Mussels

Advanced Functional Materials, EarlyView.
Mussels exhibit an unmatched proficiency for adhering to wet surfaces in salty environments—a remarkable ability that could inspire new biomedical and technical glues. The fluid protein condensates used to form the underwater mussel glue are extracted, reconstituted and characterized with advanced spectroscopy and nanomechanical analysis, revealing ...
Mathieu D. Rivard, Max Renner‐Rao, Nahid Hassanpour, Franziska Jehle, Chang‐Sheng Wang, Duy Anh Pham, Daniel J. Jackson, Xavier Banquy, Matthew J. Harrington   +8 more
wiley   +1 more source

Preferential MGMT methylation could predispose a subset of KIT/PDGFRA-WT GISTs, including SDH-deficient ones, to respond to alkylating agents

Clinical Epigenetics, 2019
Background Succinate dehydrogenase (SDH)-deficient gastrointestinal stromal tumors (GISTs) constitute a small KIT/PDGFRA-WT GIST subgroup featuring DNA methylation which, although pervasive, appears nevertheless not randomly distributed.
Riccardo Ricci, Maurizio Martini, Gloria Ravegnini, Tonia Cenci, Massimo Milione, Paola Lanza, Francesco Pierconti, Donatella Santini, Sabrina Angelini, Alberto Biondi, Fausto Rosa, Sergio Alfieri, Gennaro Clemente, Roberto Persiani, Alessandra Cassano, Maria A. Pantaleo, Luigi M. Larocca   +16 more
doaj   +1 more source

Mitosene-DNA adducts. Characterization of two major DNA monoadducts formed by 1,10-bis(acetoxy)-7-methoxymitosene upon reductive activation [PDF]

, 1997
Reductive activation of racemic 1,10-bis(acetoxy)-7-methoxymitosene WV15 in the presence of DNA, followed by enzymatic digestion and HPLC analysis, revealed the formation of various DNA adducts.
Duynhoven, John P.M. van, Gargiulo, Dario, Janssen, Lambert H.M., Maliepaard, Marc, Mol, Nico J. de, Reinhoudt, David N., Tomasz, Maria, Velzen, Ewoud J.J. van, Verboom, Willem   +8 more
core   +2 more sources

Fluorine‐Free Soft Nanocomposites for High‐Speed Liquid Impact Repellence

Advanced Functional Materials, EarlyView.
Fluorine‐free soft nanocomposite coatings are developed using silicone oil‐mediated mechanical‐stiffness control, enabling ‘dry’ liquid‐repellent surfaces that resist high‐speed water jet impacts up to ∼60 m/s. By tuning nanoparticle loading and oil content, the coatings also achieve >90% optical transparency, amphiphobicity with impact resistance to ...
Priya Mandal, Vikramjeet Singh, Rohit Gupta, Prasenjit Kabi, Manish K. Tiwari   +4 more
wiley   +1 more source

Alkylating-induced hypermutation in pancreatic neuroendocrine tumours

BMJ Oncology
Pancreatic neuroendocrine tumours (PanNET) represent the most chemosensitive subtype of NET, with alkylating agents being the mainstay treatment for advanced-stage disease. However, disease progression remains inevitable and presents significant clinical
Rodrigo G Taboada, Giovana T Torrezan, Rachel P Riechelmann   +2 more
doaj   +1 more source

Therapy related acute myeloid leukemia with t(10:16): a rare entity

Hematology Reports, 2011
Treatment related myelodysplastic syndrome (t-MDS) and acute myeloid leukemia (t-AML) are well known complications after chemotherapy for various hematologic and non-hematologic malignancies. Alkylating agents and Topoisomerase inhibitors are most widely
Guldeep K. Uppal, John Leighton, Deline Da Costa, Andrew Czulewicz, Irma E. Palazzo   +4 more
doaj   +1 more source