Results 81 to 90 of about 3,196,403 (286)

Circulating Tumor Cells Shed Shearosome Extracellular Vesicles in Capillary Bifurcations That Activate Endothelial and Immune Cells

Advanced Science, EarlyView.
Using microfluidic models of capillary networks, this study discovered that fluid shear stresses on circulating tumor cells transiting through capillary‐sized bifurcations shed a novel class of shear‐dependent large extracellular vesicle, “shearosomes”, whose proteome comprises of over 3000 distinct proteins.
Angelos Vrynas, Salime Bazban‐Shotorbani, Sara Arfan, Karishma Satia, Brian Cunningham, Gauhar Sagindykova, Mymuna Ashna, Aoyu Zhang, Diana Visan, Aisher Chen, Teige Matthews‐Palmer, Mathew Carter, Fiona Blackhall, Kathryn L. Simpson, Caroline Dive, Paul Huang, Sam H. Au   +16 more
wiley   +1 more source

Biocatalytic Alkylation of Ambident Nucleophiles Enables Selective N‐Functionalization of Heterocycles and Late‐Stage Modifications

Angewandte Chemie, EarlyView.
N‐alkylated heteroarenes are key structural motifs in bioactive compounds, but their regioselective synthesis via coupling of readily available azoles with haloalkanes remains very challenging. Here, we present a mild biocatalytic approach that proceeds on gram‐scale, is highly chemo‐ and regioselective, offering rapid access to valuable N‐alkylated ...
Felipe Ospina, Kai H. Schülke, Marius Schnutenhaus, Alina Klein, Om Desai, Shubhanshu Jain, Christine Krofta, Lukas Stratmann, Jianing Yang, Harald Gröger, Stephan C. Hammer   +10 more
wiley   +2 more sources

PURINE ALKYLATING AGENTS 2 , 6-DIAMINO-8-HALO ALKYL PURINES (POTENTIAL ANTI - MALARIALS) [PDF]

Journal of Sciences, Islamic Republic of Iran, 1992
Haloalkyl purines i.e. 2,6-diamino-8-(chloromethyl) purine 10; 2, 6-diamino-X- (chloromethyl) purine 17; 2,6-diamino-8-(chloropropylp) urine 18; were synthesized by two distinct but facile methods.
doaj  

A Novel Class of Multi‐substituted Diaryl Scaffold Derivatives Inhibit Glioblastoma Progression by Targeting CD155

Advanced Science, EarlyView.
Structural modification of clofoctol yielded a novel blood‐brain barrier‐permeable compound, B7, featuring a multi‐substituted diaryl scaffold. B7 demonstrates potent anti‐glioblastoma activity by suppressing glioblastoma stem cells proliferation, migration, and invasion through interactions with five key residues of poliovirus receptor cell adhesion ...
Yong‐jian Wang, Ting Sun, Si‐tu Xue, Zhong‐di Cai, Hong Yi, Miao Lv, Shi‐bo Kou, Rui Liu, Xiao‐zhong Peng, Zhuo‐rong Li   +9 more
wiley   +1 more source

Surface Protected Organozirconium Catalyzes C─H Alumination of Saturated Hydrocarbons

Angewandte Chemie, EarlyView.
C─H alumination of saturated aliphatic hydrocarbons is catalyzed by surface‐grafted organozirconium species, with high selectivity for the least‐hindered, terminal position, enabled by selective silylation of a small number of residual silanols in the catalyst. Exclusive mono‐alumination of methane is accomplished with more than 70 turnovers.
Sayak Banerjee, Jessica Rodriguez, Marco Mais, Frédéric A. Perras, Aaron D. Sadow   +4 more
wiley   +2 more sources

Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents

Neoplasia: An International Journal for Oncology Research
The ADP-ribosyl hydrolases PARG and ARH3 counteract PARP enzymatic activity by removing ADP-ribosylation. PARG and ARH3 activities have a synthetic lethal effect; however, the specific molecular mechanisms underlying this response remain unknown.
Rocco Caggiano, Evgeniia Prokhorova, Lena Duma, Kira Schützenhofer, Raffaella Lauro, Giuliana Catara, Rosa Marina Melillo, Angela Celetti, Rebecca Smith, S John Weroha, Scott H Kaufmann, Ivan Ahel, Luca Palazzo   +12 more
doaj  

O6-methylguanine-DNA methyltransferase (MGMT) Promoter methylation is a rare event in soft tissue sarcoma

Radiation Oncology, 2012
Background Gene silencing of O6-methylguanine–DNA methyltransferase (MGMT) by promoter methylation improves the outcome of glioblastoma patients after combined therapy of alkylating chemotherapeutic agents and radiation.
Jakob Jens, Hille Maren, Sauer Christian, Ströbel Philipp, Wenz Frederik, Hohenberger Peter   +5 more
doaj   +1 more source

CO2‐DBU‐Triggered Photoredox‐Catalyzed Direct α‐C‐H Alkylation of Alcohols

Advanced Science, EarlyView.
An efficient photoinduced and metal‐free method is developed for direct α‐C–H monoalkylation of alcohols utilizing the CO2‐DBU system as the hydrogen bond acceptor (HBA) in the presence of H2O, allowing for selective functionalization of alcohols with a broad substrate scope.
Zeyu Zhang, Zongchang Han, Yuhao Shang, Han‐Shi Hu, Jun Li, Chanjuan Xi   +5 more
wiley   +1 more source

Update on non-infectious uveitis treatment: anti-TNF-alpha and beyond

Frontiers in Ophthalmology
Non-infectious uveitis (NIU) encompasses a range of conditions marked by inflammation within various layers of the eye. NIU is a significant contributor to irreversible vision loss among the working-age population in developed countries.
Khushboo Chauhan, Khushboo Chauhan, Mudit Tyagi, Mudit Tyagi   +3 more
doaj   +1 more source

Multiple low dose streptozotocin‐induced diabetes as a model for studying autoimmune diabetes in humans

Animal Models and Experimental Medicine, EarlyView.
Multiple low dose streptozotocin‐induced diabetes is a valuable animal model of diabetes type 1. It should be improved by further research on autoantigens, microbiota and mucosal immune cells from the gut, but also from other organs. Abstract The autoimmune response directed against pancreatic β cells is the most essential pathogenic process in type 1 ...
Ivan Koprivica, Suzana Stanisavljević, Dragica Mićanović, Ivana Stojanović, Đorđe Miljković   +4 more
wiley   +1 more source