Results 91 to 100 of about 196,000 (337)

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source

An improved synthesis of adefovir and related analogues

Beilstein Journal of Organic Chemistry, 2019
An improved synthesis of the antiviral drug adefovir is presented. Problems associated with current routes to adefovir include capricious yields and a reliance on problematic reagents and solvents, such as magnesium tert-butoxide and DMF, to achieve high
David J. Jones, Eileen M. O’Leary, Timothy P. O’Sullivan   +2 more
doaj   +1 more source

Synthesis and Cytotoxicity Evaluation of 13-<em>n</em>-Alkyl Berberine and Palmatine Analogues as Anticancer Agents

Molecules, 2012
By introducing long carbon-chain alkyl groups at the C-13 position of berberine and palmatine, 13-<em>n</em>-hexyl/13-<em>n</em>-octyl berberine and palmatine chloride analogues <strong>4a</strong>–<strong>d </
Lei Zhang, Jingjing Li, Fei Ma, Shining Yao, Naisan Li, Jing Wang, Yongbin Wang, Xiuzhen Wang, Qizheng Yao   +8 more
doaj   +1 more source

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, EarlyView.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

Synthesis and anticorrosive activity of tert-amines containing cycloacetal or gem-dichlorocyclopropane fragments and quaternary ammonium salts on their basis

Тонкие химические технологии
Objectives. The work set out to synthesize tertiary amines comprising derivatives of morpholine and piperidine containing a 1,3-dioxolane or gem-dichlorocyclopropane fragment, as well as quaternary ammonium salts based on them.
Yu. G. Borisova, Sh. Sh. Dzhumaev, R. M. Sultanova, G. Z. Raskil’dina, S. S. Zlotskii   +4 more
doaj   +1 more source

Synthesis, Crystal Structure, and Biological Activity of Ethyl 4-Methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate Polymorphic Forms

Scientia Pharmaceutica, 2018
Continuing the search for new potential analgesics among the derivatives of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid, the possibility of obtaining its esters by the alkylation of the corresponding sodium salt with iodoethane in ...
Igor V. Ukrainets, Anna A. Burian, Vyacheslav N. Baumer, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Igor A. Tugaibei, Natali I. Voloshchuk, Pavlo S. Bondarenko   +7 more
doaj   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

Development of new supported catalysts for the continuous alkylation of amines with alcohols

Тонкие химические технологии
Objectives. The work set out to develop catalysts based on nickel and copper obtained by active phase chemical reduction and investigate their activity including the influence of the type of supports on the course of alkylation of amines with primary or ...
V. M. Mokhov, D. N. Nebykov, A. O. Panov, A. V. Razvalyaeva, S. E. Latyshova, M. A. Vaniev   +5 more
doaj   +1 more source

New Synthesis, Structure and Analgesic Properties of Methyl 1-R-4-Methyl-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxylates

Scientia Pharmaceutica, 2017
According to the principles of the methodology of bioisosteric replacements a series of methyl 1-R-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylates has been obtained as potential analgesics.
Liliana Azotla-Cruz, Irina V. Lijanova, Igor V. Ukrainets, Natalya V. Likhanova, Octavio Olivares-Xometl, Natalya L. Bereznyakova   +5 more
doaj   +1 more source