Results 91 to 100 of about 62,855 (239)

Total Synthesis of the Spirocyclic Bis‐Indole Alkaloid (−)‐Owerreine via a [4+2] Annulation

Angewandte Chemie, EarlyView.
The total synthesis of the bis‐indole alkaloid (−)‐owerreine has been accomplished by a diastereoselective [4+2] annulation between an enamine and an α,β−unsaturated indolenine precursor to form the 3‐spirocyclic tetrahydropyridine linkage of the natural product. DFT calculations allow an understanding of the mechanism of the key annulation.
Elisa Coll, Vincent Gandon, Cyrille Kouklovsky, Laurent Evanno, Guillaume Vincent   +4 more
wiley   +2 more sources

A challenging redox neutral Cp*Co(III)-catalysed alkylation of acetanilides with 3-buten-2-one: synthesis and key insights into the mechanism through DFT calculations

Beilstein Journal of Organic Chemistry, 2018
Traditional, established palladium cross-coupling procedures are widely applied in complex molecule synthesis; however, there is a significant disadvantage in the requirement for pre-functionalised substrates (commonly halides/triflates).
Andrew Kenny, Alba Pisarello, Arron Bird, Paula G. Chirila, Alex Hamilton, Christopher J. Whiteoak   +5 more
doaj   +1 more source

Quantitative proteomics identifies clusterin as a novel biomarker for atherosclerosis

Animal Models and Experimental Medicine, EarlyView.
This schematic illustrates the proposed mechanism. In advanced atherosclerotic lesions, upregulated CLU on the cell surface activates low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1). This interaction triggers the phosphorylation and activation of AKT.
Dengfeng Ding, Yingjie Zhang, Li Zhang, Xinou Zheng, Miaomiao Niu, Yunxiao Jia, Xuezhuang Li, Hua Chen, Chao Guo, Tao Jiang, Yuqiong Zhao   +10 more
wiley   +1 more source

Simple synthesis of pyrrolo[3,2-e]indole-1-carbonitriles

Beilstein Journal of Organic Chemistry, 2013
Alkylation of 5-nitroindol-4-ylacetonitriles with ethyl chloroacetate, α-halomethyl ketones, and chloroacetonitrile followed by a treatment of the products with chlorotrimethylsilane in the presence of DBU gives 1-cyanopyrrolo[3,2-e]indoles substituted ...
Adam Trawczyński, Robert Bujok, Zbigniew Wróbel, Krzysztof Wojciechowski   +3 more
doaj   +1 more source

NiH‐Catalyzed Enantioconvergent α‐Alkenylation of Carbonyl Compounds via Markovnikov Alkyne Hydronickellation

Angewandte Chemie, EarlyView.
A NiH‐catalyzed α‐alkenylation via Markovnikov hydronickellation of alkynes enables convenient access to α‐chrial β‐methylene carbonyl frameworks that are prevalent in biorelevant molecules. High regio‐ and enantioselectivities have been achieved with excellent functional group tolerance and applicability toward complex structures. The β‐methylene unit
Hyeontaek Nam, Seji Jang, Dongwook Kim, Sangwon Seo   +3 more
wiley   +2 more sources

Rh‐Catalyzed Chemodivergent Parallel Kinetic Resolution and Desymmetrization of Enynes and Dienynes with Acrylamides

Angewandte Chemie, EarlyView.
Rh‐catalyzed chemodivergent parallel kinetic resolution of racemic 1,6‐enynes with α‐fluoroacrylamides or mixtures of different acrylamides proceeded via [2+2+2] cycloaddition and C–H alkylation to afford structurally and stereochemically distinct products with high selectivity under mild conditions.
Shintaro Hamada, Julong Jiang, Yu Sato, Takashi Yamazaki, Satoshi Maeda, Ken Tanaka   +5 more
wiley   +2 more sources

Direct trifluoroethylation of carbonyl sulfoxonium ylides using hypervalent iodine compounds

Beilstein Journal of Organic Chemistry
A novel study on the hypervalent iodine-mediated polyfluoroalkylation of sulfoxonium ylides was developed. Sulfoxonium ylides, known for their versatility and stability, are promising substrates for numerous transformations in synthetic chemistry.
Radell Echemendía, Carlee A. Montgomery, Fabio Cuzzucoli, Antonio C. B. Burtoloso, Graham K. Murphy   +4 more
doaj   +1 more source

Decarboxylierende Alkyl‐Alkyl‐Kreuzkupplungen

Angewandte Chemie, 2016
Mikhail O. Konev, Elizabeth R. Jarvo
openaire   +2 more sources

Plasma Proteomics Identifies Thousand‐and‐One–Amino Acid Kinase 3 as a Potential Biomarker of Rheumatoid Arthritis Activity and a Novel Therapeutic Target

Arthritis &Rheumatology, EarlyView.
Objective Bone destruction associated with active rheumatoid arthritis (RA) remains a major therapeutic challenge, with a lack of reliable molecular markers reflecting bone injury. This study aims to identify novel biomarkers linked to bone destruction in active RA through proteomic analysis, providing new strategies for precise monitoring and targeted
Pengfei Xin, Wenzhen Li, Xinyu A, Jun Shen, Xiaohui Meng, Yanqin Bian, Haihui Han, Zheng Xiang, Lei Ran, Songtao Sun, Jun Xie, Tao Yue, Qi Zhu, Xiaoming Zhang, Lu Xie, Lianbo Xiao   +15 more
wiley   +1 more source

Research on synthesis of microwave‐assisted heterocyclic compounds with eco‐friendly solvents and transition metals via C–H activation

Bulletin of the Korean Chemical Society, EarlyView.
This review summarizes microwave‐assisted transition‐metal catalysis for constructing N‐ and O‐heterocycles, highlighting rapid C–H and pre‐activated C–X activation, improved selectivity, and green synthetic efficiency. Abstract Microwave‐assisted organic synthesis provides a rapid and sustainable platform for synthesizing various heterocycles ...
Woo‐Jin Park, Ye Ri Han, Hyejeong Lee
wiley   +1 more source