Results 91 to 100 of about 68,808 (283)

A highly sensitive protocol for microscopy of alkyne lipids and fluorescently tagged or immunostained proteins[S]

Journal of Lipid Research, 2016
The demand to study the cellular localization of specific lipids has led to recent advances in lipid probes and microscopy. Alkyne lipids bear a small, noninterfering tag and can be detected upon click reaction with an azide-coupled reporter. Fluorescent
Anne Gaebler, Anke Penno, Lars Kuerschner, Christoph Thiele   +3 more
doaj   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

Design, Synthesis and Characterization of Novel Isoxazole Tagged Indole Hybrid Compounds

Open Chemistry, 2020
Sixteen new isoxazole tagged indole compounds have been synthesized via copper (I) catalyzed click chemistry of the aryl hydroxamoyl chloride and an indole containing alkyne moiety. The chemical structure of the synthesized compounds has been established
Al-Qawasmeh Raed A., Al-Nazer Louy A., Dawlat-Kari Sarah A., Abu-Qatouseh Luay, Sabri Salim S., AlDamen Murad A., Sinnokrot Mutasem   +6 more
doaj   +1 more source

Rapid Photogelation of Low‐Concentration Polymer Solutions via Photodimerization of o‐Ethylnitrobenzene

Advanced Science, EarlyView.
Upon UV irradiation, flexible and tough hydrogels are formed rapidly (>0.5 s) from dilute (>0.5 wt%) solutions of o‐ethylnitrobenzene–modified PVA. At ∼1.5 wt%, the hydrogels withstand up to 10 MPa compression, remain handleable even after 200‐fold swelling.
Masaaki Okihara, Ayaka Tomoda, Kana Morishita, Toshiyuki Takagi, Kimio Sumaru   +4 more
wiley   +1 more source

Total Synthesis of Chiral Falcarindiol Analogues Using BINOL-Promoted Alkyne Addition to Aldehydes

Molecules, 2016
An enantioselective total synthesis of chiral falcarindiol analogues from buta-1,3-diyn-1-yltriisopropylsilane is reported. The key step in this synthesis is BINOL-promoted asymmetric diacetylene addition to aldehydes.
Li Wang, Ping-Ping Shou, Si-Ping Wei, Chun Zhang, Shuang-Xun Li, Ping-Xian Liu, Xi Du, Qin Wang   +7 more
doaj   +1 more source

Fluorohydration of alkynes via I(I)/I(III) catalysis

Beilstein Journal of Organic Chemistry, 2020
Substrate specificity is ubiquitous in biological catalysis, but less pervasive in the realm of small-molecule catalysis. Herein, we disclose an intriguing example of substrate specificity that was observed whilst exploring catalysis-based routes to ...
Jessica Neufeld, Constantin G. Daniliuc, Ryan Gilmour   +2 more
doaj   +1 more source

Iridium Complex Catalyzed Carbonylative Alkyne−Alkyne Coupling for the Synthesis of Cyclopentadienones

, 2016
Catalytic carbonylative alkyne−alkyne coupling proceeds using iridium−phosphine complexes under carbon monoxide at atmospheric pressure or a partial pressure of 0.2 atm.
Kentaro Takagi (689304), Hiroyuki Ishida (769430), Koji Yamashita (3063837), Takanori Shibata (425963)   +3 more
core   +1 more source

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

Advanced Science, EarlyView.
Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin, Kang Duan, Rui Wan, Tao Jiang, Jinzhe Wei, Miao Sun, Mariia A. Skryl'nikova, Maxim A. Gureev, Zhi‐Min Zhang, Zhang Zhang, Ke Ding, Nan Ma, Tongzheng Liu, Yi Tan, Zhengqiu Li   +14 more
wiley   +1 more source

alkynes

, 2008
Citation: 'alkynes' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.A00236 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms. Requests for commercial usage
openaire   +1 more source

Pinwheel-like Curved Aromatics from the Cyclotrimerization of Strained Alkyne Cycloparaphenylenes [PDF]

Curved aromatic hydrocarbons often display better solubility and more desirable electronic properties in comparison to their flat counterparts. Macrocyclic curved aromatics possess these traits as well as shape-persistent pores ideal for host-guest ...
Lev, Zakharov, Ramesh, Jasti, Julia, Fehr, Tara, Clayton, Tavis, Price   +4 more
core   +2 more sources