Results 151 to 160 of about 90,721 (285)

A Doxorubicin‐Loaded Liposomes Baghdadite System for Localized Osteosarcoma Therapy and Bone Regeneration

Advanced NanoBiomed Research, EarlyView.
This study presents a multifunctional Baghdadite ceramic implant integrating doxorubicin‐loaded liposomes via ion‐assisted plasma polymer coating for localized osteosarcoma therapy. The platform enables drug retention, sustained release, tumor cell inhibition, osteoconductivity, and antibacterial activity, offering a mechanically robust strategy for ...
Sally Kortam, Zufu Lu, Iman Roohani, Ghazal Shineh, Leila Mamizadeh Janghour, Huu Nguyen Ngoc, Pooria Lesani, Behnam Akhavan, Hala Zreiqat   +8 more
wiley   +1 more source

From Covalent Traps to Fluorescent Beacons: The Expanding Arsenal of Chemical Probes for Studying Ubiquitin and Ubiquitin‐Like Proteins

Angewandte Chemie, EarlyView.
A large variety of chemistry‐based ubiquitin probes have been developed. ABSTRACT Ubiquitin (Ub) and ubiquitin‐like proteins (Ubls) orchestrate diverse cellular processes through reversible post‐translational modification of target proteins. Their conjugation is governed by a cascade of E1 activating, E2 conjugating, and E3 ligating enzymes, while ...
Saibal Chanda, Wenshe Ray Liu
wiley   +2 more sources

Harnessing Methyltransferase‐Guided Targeting for Sequence‐Specific Proximity Labeling of DNA

Angewandte Chemie, EarlyView.
A novel methyltransferase‐mediated approach leveraging rationally designed S‐adenosyl‐L‐methionine (SAM) analogues was developed to achieve sequence‐specific DNA labeling but in proximity to the natural transfer site, addressing key limitations of previously established methods, including ligand instability and methylation‐sensitive labeling.
Xiong Chen, Gang Wen, Niels Ooghe, Sergey Abakumov, Taoufik Rohand, Volker Leen, Peter Dedecker, Tanja Weil, Johan Hofkens   +8 more
wiley   +2 more sources

Fluorine‐18‐Labeled Nucleotide Analogs Targeting Ecto‐5'‐Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors

Angewandte Chemie, EarlyView.
Fluorine‐18‐labeled CD73 inhibitor [18F]PSB‐19427 enables noninvasive PET mapping of CD73 overexpression in triple‐negative breast (TNBC) and pancreatic cancer. For [18F]PSB‐19427, specific binding in human tumor tissues, favorable biodistribution with prolonged blood retention, robust tumor uptake, and superiority to [18F]FDG in a TNBC model ...
Clemens Dobelmann, Constanze C. Schmies, Georg Wilhelm Rolshoven, Mirko Scortichini, Stefan Wagner, Andreas Isaak, Riham M. Idris, Jennifer Dabel, Lucie Grey, Karolina Losenkova, Susanne Moschütz, Haneen Al Hroub, Antje Keim, Sandra Höppner, Jouko Sandholm, Pia Boström, Maija Hollmén, Norbert Sträter, Sven Hermann, Gennady G. Yegutkin, Kenneth A. Jacobson, Sonja Schelhaas, Christa E. Müller, Anna Junker   +23 more
wiley   +2 more sources

Trisoxazole Macrolides Potentiate the Microtubule Assembly and Antimitotic Activities of Taxanes

Angewandte Chemie, EarlyView.
Photoaffinity experiments identified tubulin as a new target of mycalolides. Though weakly cytotoxic, the trisoxazole macrolactone moiety enhanced paclitaxel's microtubule assembly and antimitotic effects. Molecular modeling studies suggested that MyC stabilizes α/β‐tubulin heterodimer interactions.
Shohei Ebihara, Rio Takaiso, Shota Kawaguchi, Atsunori Oshima, Masaki Kita   +4 more
wiley   +2 more sources

Synthesis of Conjugated Linear and Cyclic Polyynes by Selective Alkyne Metathesis

Angewandte Chemie, EarlyView.
The formation of polyynes with an odd number of conjugated triple bonds is challenging, particularly for complex architectures since most established methods rely on irreversible C–C bond‐forming reactions. To address this, we have developed the synthesis of triynes via alkyne metathesis.
Julien Escudero, Jonathan Long, Dylan Bouëtard, Jennifer Morvan, Mehdi Koohgard, Angelika Neitzel, Dirk Bockfeld, Shedrack Nwachukwu, Thierry Roisnel, Rik R. Tykwinski, Matthias Tamm, Marc Mauduit, Yann Trolez   +12 more
wiley   +2 more sources

Comparative analysis of alkyne- and desthiobiotinylated photoaffinity probes for chemotranscriptomic profiling. [PDF]

RSC Chem Biol
van den Homberg DAL, Poulladofonou G, Dekens A, Velema WA.   +3 more
europepmc   +1 more source

Beyond Hydrogen Bonding: π···π Stacking Directed Self‐Assembly of Carboxylic Acid Clusters in the Gas Phase

Angewandte Chemie, EarlyView.
A critical transformation from hydrogen‐bonded trimers to π–π stacked tetramers is unveiled by microwave spectroscopy, highlighting dispersion as a key force in directing carboxylic acid aggregation. ABSTRACT Carboxylic acids critically influence atmospheric chemistry by modulating acidity, new particle formation, and aerosol growth.
Jingling Hong, Melanie Schnell, Mingfei Zhou, Weixing Li   +3 more
wiley   +2 more sources

Probing a Reactive Alkyne Center Aligned via a Triphenylmethane Tripod on Au(111) for Electric Field-Induced Chemistry by STM and TERS. [PDF]

Small
Mennicken S, Li G, Zhu LY, Schäfer D, Reichenauer T, Mehrparvar S, Choi N, Zhang Y, Haberhauer G, Dong ZC, Schlücker S.   +10 more
europepmc   +1 more source

Simultaneous Imaging of Cu+ and Cu2+ in Neural Cells Using DNAzyme Probes Reveals Mechanistic Link Between Copper Redox Imbalance and Amyloid Pathology

Angewandte Chemie, EarlyView.
We develop Cu+‐ and Cu2+‐specific DNAzyme fluorescent probes to visualize both copper redox states in living neurons. Aβ oligomers cause intracellular copper overload, triggering FDX1 dependent cuproptosis and generating ROS. This work links copper redox imbalance with Aβ pathology and offers a selective, sensitive way to monitor copper homeostasis in ...
Xiangli Shao, Zhenglin Yang, Zhihao Xu, Weijie Guo, Whitney Lewis, Boyi Gan, Yi Lu   +6 more
wiley   +2 more sources