Results 171 to 180 of about 66,858 (295)

Chemical Synthesis and Functional Screening of an 800 000‐Member Library Using a Peptide‐Pairing Strategy

open access: yesAngewandte Chemie, EarlyView.
Chemical peptide synthesis allows the generation of structurally highly diverse compounds suited for ligand development, but current methods in parallel peptide synthesis limit the achievable library size to a few thousand. A strategy is presented based on combinatorial pairing of short peptides via disulfide linkage that enables the generation and ...
Anne Zarda   +5 more
wiley   +1 more source

Charge‐Transfer Assembly of Electrically Conductive Metal–Organic Cages

open access: yesAngewandte Chemie, EarlyView.
Electrically conductive and permanently porous metal–organic cages are realized using charge‐transfer assembly between electron‐donating cages and electron‐accepting molecules, which self‐assemble to create new charge transport pathways without sacrificing access to internal void space.
Kyungseop Lee   +3 more
wiley   +1 more source

Diamondiyne: A 3D Carbon Allotrope With Mixed sp–sp3 Hybridization

open access: yesAngewandte Chemie, EarlyView.
A new carbon allotrope with mixed sp–sp3 hybridization has been synthesized through delicately controlled kinetics at a liquid–liquid interface. The resulting material, termed diamondiyne, exhibits an expanded diamond‐type network in the form of small crystallites in a continuous all‐carbon film.
Yizhou Yang   +12 more
wiley   +1 more source

Sequential Single-Crystal-to-Single-Crystal Transformations Generate Polymer Polymorphs. [PDF]

open access: yesAngew Chem Int Ed Engl
Lal A   +4 more
europepmc   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

open access: yesAngewandte Chemie, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee   +5 more
wiley   +1 more source

Mechanical Caging of Nucleic Acids Enabled by Light‐Activated Synthetic Molecular Motors

open access: yesAngewandte Chemie, EarlyView.
A synthetic light‐driven molecular motor imposes mechanical constraints on nucleic acids, enabling “mechanical caging” as a new mode to regulate DNA structure and function through mechanical input rather than chemical masking. ABSTRACT Control over nucleic acid activity is central to biotechnology and therapeutic development.
Yuchen Ma   +10 more
wiley   +1 more source

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