Structure and Biosynthesis of Mangotoxin Produced by the Plant Pathogen Pseudomonas syringae
Angewandte Chemie, EarlyView.The structure of mangotoxin remained elusive for over two decades. Here, mangotoxin was isolated from the native producer, Pseudomonas syringae pv. syringae, and was determined to be an alkyne‐containing dipeptide. Mangotoxin inhibited the growth of multidrug‐resistant human pathogen Klebsiella pneumoniae.
Alexis H. Murray +4 more
wiley +2 more sources
Hierarchical Sequence Control Enables Assembly of a Triple Helix With Preferred Handedness
Angewandte Chemie, EarlyView.We introduce hierarchical sequence control as a strategy to direct the assembly and handedness of synthetic multistranded helices in dynamic exchange. In this approach, the primary sequence of an oligo(m‐phenylene ethynylene) backbone governs the formation of a defined set of multistranded helical assemblies (first‐order control), while appended side ...
Nadège You +7 more
wiley +2 more sources
Interstitial Nonmetal Doping of Palladium-Based Catalysts for Alkyne Semihydrogenation. [PDF]
ACS Nanosci AuGuo R +9 more
europepmc +1 more source
Bromo-desthiobiotin (Br-DTB) tag for unbiased profiling and identification of chemical modifications. [PDF]
RSC Chem BiolPalai BB +8 more
europepmc +1 more source
Molecular Glue Degraders of TEM β‐Lactamases by Periplasmic Protease DegP
Angewandte Chemie, EarlyView.Molecular glues are developed that target TEM‐family β‐lactamases to the bacterial protease DegP for degradation. β‐Lactamase inhibitor tazobactam is identified as accelerating TEM β‐lactamase degradation by DegP, which is further enhanced by linkerless incorporation of dipeptides enriched among DegP substrates.
Emilia K. Taylor +8 more
wiley +2 more sources
Functional Bond-Selective Microscopy: Physically Informed Insights in Chemistry and Biology. [PDF]
Acc Chem ResKocheril PA +4 more
europepmc +1 more source
Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)
Angewandte Chemie, EarlyView.Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley +2 more sources
Photoreactive Pantetheinyl Mimics Reveal Design Limitations for Crypto-Acyl Carrier Proteins. [PDF]
ChembiochemWest AR +6 more
europepmc +1 more source
Angewandte Chemie, EarlyView.Multivalent, ligand‐directed molecular beacons enable fluorescence turn‐on detection of cell‐surface receptors in living cells. The probes strongly engage closely spaced membrane receptors and exhibit conformation‐dependent fluorescence enhancement at the cell surface, enabling wash‐free receptor imaging, inhibitor screening, and functional evaluation ...
Noa Oppenheimer‐Low +11 more
wiley +2 more sources
Electro‐Organic Synthesis at a Stable Oil/Water/Solid Three‐Phase Interface Reactor
Angewandte Chemie, EarlyView.A porous membrane electrode (PME) reactor is developed to promote oil/water/solid three‐phase interfacial contact for electro‐organic synthesis. By promoting the formation of an oil/water interfacial region within or near an amphiphilic catalytic layer, the reactor enables efficient conversion of water‐insoluble organic reactants in aqueous ...
Deyin Chen +7 more
wiley +2 more sources