Results 181 to 190 of about 68,808 (283)

Light‐Gated Control of Brownian Rotation by a Molecular Motor

Angewandte Chemie, EarlyView.
A light‐driven molecular motor acts as a reversible steric gate for a nearby Brownian rotor. Photoisomerization switches the rotor between fast and hindered rotational regimes by modulating steric congestion around the rotational axis. The motor–rotor architecture enables a five‐order‐of‐magnitude difference in the rotational barrier, demonstrating ...
Lukáš Severa, Kateřina Bezděková, Katarina Majerová Varga, Guillaume Bastien, Miroslav Stroka, Ivana Císařová, Martin Dračínský, Jiří Kaleta   +7 more
wiley   +1 more source

Synthesis and Biological Evaluation of O6C-Salvinorin Alkyne Probes. [PDF]

Synthesis (Stuttg)
Cotter E, Leoni G, Dao N, Hill SJ, Faragher A, Dang VQ, Bohn LM, Shenvi RA.   +7 more
europepmc   +1 more source

Sequence‐Controlled Helical Ladder Polymers: Impact of Stereochemical Sequence on Helical Geometry and Chiral Recognition

Angewandte Chemie, EarlyView.
Nature programs distinct secondary structures and functions through subtle stereochemical differences, as exemplified by amylose and cellulose. Translating this principle into synthetic ladder polymers, stereochemical sequence control gives rise to diastereomeric coil‐ and ribbon‐type helices with complementary chiral recognition, demonstrating ...
Tomoyuki Ikai, Kanta Wakabayashi, Masaya Yoshida, Kosuke Oki, Eiji Yashima   +4 more
wiley   +1 more source

Bioorthogonal Tools for Ethanolamine Lipids and Protein Conjugates. [PDF]

Angew Chem Int Ed Engl
Cho YT, Jao CY, Xia Z, White-Mathieu BM, Salic A, Baskin JM.   +5 more
europepmc   +1 more source

Difluoromethylenation of Alkynes: Streamlined Access to Allyl Difluorides

Angewandte Chemie, EarlyView.
Stabilizing primary oxocarbenium in HF/pyridine unlocks a direct alkyne difluoromethylenation – an efficient route to synthetically‐relevant allyl difluorides in a single step. ABSTRACT A direct difluoromethylenation of alkynes has been developed using HF/pyridine as a dual acidic and fluorinating medium. The reaction proceeds via in situ generation of
Fabien Naullet, Sourav Mondal, Frédéric Guégan, Bastien Michelet, Sébastien Thibaudeau   +4 more
wiley   +1 more source

Gold(I) vinylidenes as intermediates in catalysis: experimental and computational evidence. [PDF]

Beilstein J Org Chem
Sugranyes AR, Escofet I, Echavarren AM.
europepmc   +1 more source

Gain‐of‐Function Engineering of the NifEN Scaffold Into a Self‐Assembling Nitrogenase

Angewandte Chemie, EarlyView.
From scaffold to enzyme: Systematic engineering of the cofactor maturation scaffold NifEN reconstructs the P→M electron relay along with cofactor coordination and proton gating at the S2B site, converting NifEN into a functional nitrogenase capable of ATP‐dependent N2 reduction both in vitro and in vivo.
Yimo Yang, Chi Chung Lee, Steve Ortiz, Markus W. Ribbe, Yilin Hu   +4 more
wiley   +1 more source

Z‐Retentive Enantioselective Rh‐Catalyzed Hydroarylation of E,Z‐Dienes

Angewandte Chemie, EarlyView.
The Rh‐catalyzed hydroarylation of conjugated E,Z‐dienoates is found to proceed with high selectivity for addition to the E‐alkene unit. Mechanistic analysis of this Z‐retentive process points towards preferred binding of the E‐alkene unit to a Rh‐aryl species to give rise to the observed selectivity and that Rh‐enolate protonolysis to be turnover ...
Wesley McNutt, Hima Kozhummal, Abdullah Al‐Mashqbeh, Alex Brown, Rylan J. Lundgren   +4 more
wiley   +1 more source

A Unified Platform for Direct Alkynylation from Alcohols via Deoxygenative Metallaphotoredox Catalysis. [PDF]

J Am Chem Soc
Li YH, MacMillan DWC.
europepmc   +1 more source

Chemoenzymatic Synthesis of 6‐Sulfo Sialyl Lewisx Containing Glycans to Probe the Receptor Specificity of MERS Coronavirus

Angewandte Chemie, EarlyView.
A chemoenzymatic methodology is described that provided a panel of 6‐sulfo sialyl Lewisx‐containing glycans that were probed for receptor specificity of MERS‐CoV. Although the fucoside of 6‐sulfo‐SLex does not directly interact with the spike, it pre‐organizes the molecule into a conformation to allow a salt bridge between the sulfate and the ...
Yunfei Wu, Anne L.M. Kimpel, Jacobus P. van Trijp, Elif Uslu, Gaёl M. Vos, Luca Unione, Robert P. de Vries, Geert‐Jan Boons   +7 more
wiley   +1 more source